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GSK3 as a Regulator of Cytoskeleton Architecture: Consequences for Health and Disease

Glycogen synthase kinase 3 (GSK3) was initially isolated as a critical protein in energy metabolism. However, subsequent studies indicate that GSK-3 is a multi-tasking kinase that links numerous signaling pathways in a cell and plays a vital role in the regulation of many aspects of cellular physiol...

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Autores principales: Hajka, Daria, Budziak, Bartosz, Pietras, Łukasz, Duda, Przemysław, McCubrey, James A., Gizak, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393567/
https://www.ncbi.nlm.nih.gov/pubmed/34440861
http://dx.doi.org/10.3390/cells10082092
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author Hajka, Daria
Budziak, Bartosz
Pietras, Łukasz
Duda, Przemysław
McCubrey, James A.
Gizak, Agnieszka
author_facet Hajka, Daria
Budziak, Bartosz
Pietras, Łukasz
Duda, Przemysław
McCubrey, James A.
Gizak, Agnieszka
author_sort Hajka, Daria
collection PubMed
description Glycogen synthase kinase 3 (GSK3) was initially isolated as a critical protein in energy metabolism. However, subsequent studies indicate that GSK-3 is a multi-tasking kinase that links numerous signaling pathways in a cell and plays a vital role in the regulation of many aspects of cellular physiology. As a regulator of actin and tubulin cytoskeleton, GSK3 influences processes of cell polarization, interaction with the extracellular matrix, and directional migration of cells and their organelles during the growth and development of an animal organism. In this review, the roles of GSK3–cytoskeleton interactions in brain development and pathology, migration of healthy and cancer cells, and in cellular trafficking of mitochondria will be discussed.
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spelling pubmed-83935672021-08-28 GSK3 as a Regulator of Cytoskeleton Architecture: Consequences for Health and Disease Hajka, Daria Budziak, Bartosz Pietras, Łukasz Duda, Przemysław McCubrey, James A. Gizak, Agnieszka Cells Review Glycogen synthase kinase 3 (GSK3) was initially isolated as a critical protein in energy metabolism. However, subsequent studies indicate that GSK-3 is a multi-tasking kinase that links numerous signaling pathways in a cell and plays a vital role in the regulation of many aspects of cellular physiology. As a regulator of actin and tubulin cytoskeleton, GSK3 influences processes of cell polarization, interaction with the extracellular matrix, and directional migration of cells and their organelles during the growth and development of an animal organism. In this review, the roles of GSK3–cytoskeleton interactions in brain development and pathology, migration of healthy and cancer cells, and in cellular trafficking of mitochondria will be discussed. MDPI 2021-08-14 /pmc/articles/PMC8393567/ /pubmed/34440861 http://dx.doi.org/10.3390/cells10082092 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hajka, Daria
Budziak, Bartosz
Pietras, Łukasz
Duda, Przemysław
McCubrey, James A.
Gizak, Agnieszka
GSK3 as a Regulator of Cytoskeleton Architecture: Consequences for Health and Disease
title GSK3 as a Regulator of Cytoskeleton Architecture: Consequences for Health and Disease
title_full GSK3 as a Regulator of Cytoskeleton Architecture: Consequences for Health and Disease
title_fullStr GSK3 as a Regulator of Cytoskeleton Architecture: Consequences for Health and Disease
title_full_unstemmed GSK3 as a Regulator of Cytoskeleton Architecture: Consequences for Health and Disease
title_short GSK3 as a Regulator of Cytoskeleton Architecture: Consequences for Health and Disease
title_sort gsk3 as a regulator of cytoskeleton architecture: consequences for health and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393567/
https://www.ncbi.nlm.nih.gov/pubmed/34440861
http://dx.doi.org/10.3390/cells10082092
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