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GSK3 as a Regulator of Cytoskeleton Architecture: Consequences for Health and Disease
Glycogen synthase kinase 3 (GSK3) was initially isolated as a critical protein in energy metabolism. However, subsequent studies indicate that GSK-3 is a multi-tasking kinase that links numerous signaling pathways in a cell and plays a vital role in the regulation of many aspects of cellular physiol...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393567/ https://www.ncbi.nlm.nih.gov/pubmed/34440861 http://dx.doi.org/10.3390/cells10082092 |
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author | Hajka, Daria Budziak, Bartosz Pietras, Łukasz Duda, Przemysław McCubrey, James A. Gizak, Agnieszka |
author_facet | Hajka, Daria Budziak, Bartosz Pietras, Łukasz Duda, Przemysław McCubrey, James A. Gizak, Agnieszka |
author_sort | Hajka, Daria |
collection | PubMed |
description | Glycogen synthase kinase 3 (GSK3) was initially isolated as a critical protein in energy metabolism. However, subsequent studies indicate that GSK-3 is a multi-tasking kinase that links numerous signaling pathways in a cell and plays a vital role in the regulation of many aspects of cellular physiology. As a regulator of actin and tubulin cytoskeleton, GSK3 influences processes of cell polarization, interaction with the extracellular matrix, and directional migration of cells and their organelles during the growth and development of an animal organism. In this review, the roles of GSK3–cytoskeleton interactions in brain development and pathology, migration of healthy and cancer cells, and in cellular trafficking of mitochondria will be discussed. |
format | Online Article Text |
id | pubmed-8393567 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83935672021-08-28 GSK3 as a Regulator of Cytoskeleton Architecture: Consequences for Health and Disease Hajka, Daria Budziak, Bartosz Pietras, Łukasz Duda, Przemysław McCubrey, James A. Gizak, Agnieszka Cells Review Glycogen synthase kinase 3 (GSK3) was initially isolated as a critical protein in energy metabolism. However, subsequent studies indicate that GSK-3 is a multi-tasking kinase that links numerous signaling pathways in a cell and plays a vital role in the regulation of many aspects of cellular physiology. As a regulator of actin and tubulin cytoskeleton, GSK3 influences processes of cell polarization, interaction with the extracellular matrix, and directional migration of cells and their organelles during the growth and development of an animal organism. In this review, the roles of GSK3–cytoskeleton interactions in brain development and pathology, migration of healthy and cancer cells, and in cellular trafficking of mitochondria will be discussed. MDPI 2021-08-14 /pmc/articles/PMC8393567/ /pubmed/34440861 http://dx.doi.org/10.3390/cells10082092 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hajka, Daria Budziak, Bartosz Pietras, Łukasz Duda, Przemysław McCubrey, James A. Gizak, Agnieszka GSK3 as a Regulator of Cytoskeleton Architecture: Consequences for Health and Disease |
title | GSK3 as a Regulator of Cytoskeleton Architecture: Consequences for Health and Disease |
title_full | GSK3 as a Regulator of Cytoskeleton Architecture: Consequences for Health and Disease |
title_fullStr | GSK3 as a Regulator of Cytoskeleton Architecture: Consequences for Health and Disease |
title_full_unstemmed | GSK3 as a Regulator of Cytoskeleton Architecture: Consequences for Health and Disease |
title_short | GSK3 as a Regulator of Cytoskeleton Architecture: Consequences for Health and Disease |
title_sort | gsk3 as a regulator of cytoskeleton architecture: consequences for health and disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393567/ https://www.ncbi.nlm.nih.gov/pubmed/34440861 http://dx.doi.org/10.3390/cells10082092 |
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