Cargando…

TYK2 in Cancer Metastases: Genomic and Proteomic Discovery

SIMPLE SUMMARY: Cancer deaths are predominantly due to metastases rather than the primary tumors, and thus there is an urgent need for the discovery of more effective drug therapies for metastatic cancer. Recent genomics, transcriptomics, and proteomics studies have identified tyrosine kinase 2 (TYK...

Descripción completa

Detalles Bibliográficos
Autores principales:	Borcherding, Dana C., He, Kevin, Amin, Neha V., Hirbe, Angela C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393599/ https://www.ncbi.nlm.nih.gov/pubmed/34439323 http://dx.doi.org/10.3390/cancers13164171

Ejemplares similares

MEK Inhibition Synergizes with TYK2 Inhibitors in NF1-Associated Malignant Peripheral Nerve Sheath Tumors
por: Borcherding, Dana C., et al.
Publicado: (2023)

TYK2 promotes malignant peripheral nerve sheath tumor progression through inhibition of cell death
por: Qin, Wenjing, et al.
Publicado: (2019)

TYK2 in Tumor Immunosurveillance
por: Karjalainen, Anzhelika, et al.
Publicado: (2020)

TYK2: An Upstream Kinase of STATs in Cancer
por: Wöss, Katharina, et al.
Publicado: (2019)

TYK2 in Immune Responses and Treatment of Psoriasis
por: Shang, Lin, et al.
Publicado: (2022)

In vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity
por: Prchal-Murphy, Michaela, et al.
Publicado: (2015)

Tyk2 Targeting in Immune-Mediated Inflammatory Diseases
por: Rusiñol, Lluís, et al.
Publicado: (2023)

Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage
por: Li, Zhi, et al.
Publicado: (2020)

Tyk2 is a tumor suppressor in colorectal cancer
por: Moritsch, Stefan, et al.
Publicado: (2022)

TYK2 Variants in B-Acute Lymphoblastic Leukaemia
por: Turrubiartes-Martínez, Edgar, et al.
Publicado: (2020)

Proteomic Profiling and Biomarker Discovery in Colorectal Liver Metastases
por: Wong, Geoffrey Yuet Mun, et al.
Publicado: (2022)

TYK2 Promoter Variant and Diabetes Mellitus in the Japanese
por: Nagafuchi, Seiho, et al.
Publicado: (2015)

A TYK2 Gene Mutation c.2395G>A Leads to TYK2 Deficiency: A Case Report and Literature Review
por: Wu, Peilin, et al.
Publicado: (2020)

A New “TYK” Tok Era for the Study of Long Noncoding RNAs in Pulmonary Hypertension
por: Hafeez, Neha, et al.
Publicado: (2020)

Oncogenic TYK2 P760L kinase is effectively targeted by combinatorial TYK2, mTOR and CDK4/6 kinase blockade
por: Woess, Katharina, et al.
Publicado: (2022)

Structural basis of IFNα receptor recognition by TYK2
por: Wallweber, Heidi J.A., et al.
Publicado: (2014)

Functional characterization of NPM1–TYK2 fusion oncogene
por: Kuravi, Sudhakiranmayi, et al.
Publicado: (2022)

Prognostic values and clinical relationship of TYK2 in laryngeal squamous cell cancer
por: Fang, Lucheng, et al.
Publicado: (2021)

Association of germline TYK2 variation with lung cancer and non‐Hodgkin lymphoma risk
por: Yarmolinsky, James, et al.
Publicado: (2022)

Diabetes, the TYK2 Gene and the Interferon Response: In Search for Environmental Causes
por: Toniolo, Antonio, et al.
Publicado: (2017)

Triple-action inhibitory mechanism of allosteric TYK2-specific inhibitors
por: Wang, Jimin, et al.
Publicado: (2023)

Role of Tyk-2 in Th9 and Th17 cells in allergic asthma
por: Übel, Caroline, et al.
Publicado: (2014)

Compound heterozygous TYK2 mutations underlie primary immunodeficiency with T-cell lymphopenia
por: Nemoto, Michiko, et al.
Publicado: (2018)

Expression analysis of IFNAR1 and TYK2 transcripts in COVID-19 patients
por: Akbari, Mohammadarian, et al.
Publicado: (2022)

TYK2 single-nucleotide variants associated with the severity of COVID-19 disease
por: Zabihi Rizi, Fateme, et al.
Publicado: (2023)

SIAH2 antagonizes TYK2-STAT3 signaling in lung carcinoma cells
por: Müller, Sylvia, et al.
Publicado: (2014)

A comparative proteome analysis links tyrosine kinase 2 (Tyk2) to the regulation of cellular glucose and lipid metabolism in response to poly(I:C)
por: Grunert, Tom, et al.
Publicado: (2011)

Patterns of Extrapulmonary Metastases in Sarcoma Surveillance
por: Hong, Zachery, et al.
Publicado: (2021)

TYK2 correlates with immune infiltration: A prognostic marker for head and neck squamous cell carcinoma
por: He, Yaodong, et al.
Publicado: (2022)

TYK2 Kinase Activity Is Required for Functional Type I Interferon Responses In Vivo
por: Prchal-Murphy, Michaela, et al.
Publicado: (2012)

TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity
por: Mori, Raffaele, et al.
Publicado: (2017)

Single Nucleotide Polymorphism of TYK2 Gene and Susceptibility to Rheumatoid Arthritis in Iranian Population
por: Mohamadhosseini, Azadeh, et al.
Publicado: (2019)

Use of TYK2 inhibitor to relieve reactive granulomatous dermatitis due to myelodysplastic syndrome
por: Huang, Christina, et al.
Publicado: (2023)

Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma
por: Prutsch, Nicole, et al.
Publicado: (2018)

Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor
por: Argiriadi, Maria A, et al.
Publicado: (2012)

Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome
por: Kreins, Alexandra Y., et al.
Publicado: (2015)

Demonstration of In Vitro to In Vivo Translation of a TYK2 Inhibitor That Shows Cross Species Potency Differences
por: Gerstenberger, Brian S., et al.
Publicado: (2020)

Comprehensive analysis of three TYK2 gene variants in the susceptibility to Chagas disease infection and cardiomyopathy
por: Leon Rodriguez, Daniel A., et al.
Publicado: (2018)

JAK3 and TYK2 Serve as Prognostic Biomarkers and Are Associated with Immune Infiltration in Stomach Adenocarcinoma
por: Meng, Lingkai, et al.
Publicado: (2020)

TYK2 inhibition reduces type 3 immunity and modifies disease progression in murine spondyloarthritis
por: Gracey, Eric, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_rbs5ckec8jt39i7b8dpgpspjcg