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The Role of Immune-Related miRNAs in the Pathology of Kidney Transplantation

MicroRNAs (miRNAs) are members of the non-coding regulatory RNA family that play pivotal roles in physiological and pathological conditions, including immune response. They are particularly interesting as promising therapeutic targets, prognostic and diagnostic markers due to their easy detection in...

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Autores principales: Boštjančič, Emanuela, Večerić-Haler, Željka, Kojc, Nika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393721/
https://www.ncbi.nlm.nih.gov/pubmed/34439863
http://dx.doi.org/10.3390/biom11081198
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author Boštjančič, Emanuela
Večerić-Haler, Željka
Kojc, Nika
author_facet Boštjančič, Emanuela
Večerić-Haler, Željka
Kojc, Nika
author_sort Boštjančič, Emanuela
collection PubMed
description MicroRNAs (miRNAs) are members of the non-coding regulatory RNA family that play pivotal roles in physiological and pathological conditions, including immune response. They are particularly interesting as promising therapeutic targets, prognostic and diagnostic markers due to their easy detection in body fluids and stability. There is accumulating evidence that different miRNAs provide disease-specific signatures in liquid samples of distinct kidney injuries. Using experimental models and human samples, there have been numerous suggestions that immune-related miRNAs are also important contributors to the development of different kidney diseases as well as important markers for monitoring response after kidney transplantation. However, there are limited data for understanding their function in the molecular pathways of allograft pathologies. In our review, we focused on microRNAs that are related to different aspects of immune response after kidney transplantation.
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spelling pubmed-83937212021-08-28 The Role of Immune-Related miRNAs in the Pathology of Kidney Transplantation Boštjančič, Emanuela Večerić-Haler, Željka Kojc, Nika Biomolecules Review MicroRNAs (miRNAs) are members of the non-coding regulatory RNA family that play pivotal roles in physiological and pathological conditions, including immune response. They are particularly interesting as promising therapeutic targets, prognostic and diagnostic markers due to their easy detection in body fluids and stability. There is accumulating evidence that different miRNAs provide disease-specific signatures in liquid samples of distinct kidney injuries. Using experimental models and human samples, there have been numerous suggestions that immune-related miRNAs are also important contributors to the development of different kidney diseases as well as important markers for monitoring response after kidney transplantation. However, there are limited data for understanding their function in the molecular pathways of allograft pathologies. In our review, we focused on microRNAs that are related to different aspects of immune response after kidney transplantation. MDPI 2021-08-12 /pmc/articles/PMC8393721/ /pubmed/34439863 http://dx.doi.org/10.3390/biom11081198 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Boštjančič, Emanuela
Večerić-Haler, Željka
Kojc, Nika
The Role of Immune-Related miRNAs in the Pathology of Kidney Transplantation
title The Role of Immune-Related miRNAs in the Pathology of Kidney Transplantation
title_full The Role of Immune-Related miRNAs in the Pathology of Kidney Transplantation
title_fullStr The Role of Immune-Related miRNAs in the Pathology of Kidney Transplantation
title_full_unstemmed The Role of Immune-Related miRNAs in the Pathology of Kidney Transplantation
title_short The Role of Immune-Related miRNAs in the Pathology of Kidney Transplantation
title_sort role of immune-related mirnas in the pathology of kidney transplantation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393721/
https://www.ncbi.nlm.nih.gov/pubmed/34439863
http://dx.doi.org/10.3390/biom11081198
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