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The Role of Total Parenteral Nutrition in Patients with Peritoneal Carcinomatosis: A Systematic Review and Meta-Analysis

SIMPLE SUMMARY: Patients with peritoneal carcinomatosis often develop complications which prevent them from receiving adequate oral intake. This can contribute to malnutrition, as well as increased morbidity and mortality. In such patients, total parenteral nutrition, which involves the intravenous...

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Autores principales: Ong, Xing-Yi Sarah, Sultana, Rehena, Tan, Joey Wee-Shan, Tan, Qiu Xuan, Wong, Jolene Si Min, Chia, Claramae Shulyn, Ong, Chin-Ann Johnny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393754/
https://www.ncbi.nlm.nih.gov/pubmed/34439309
http://dx.doi.org/10.3390/cancers13164156
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author Ong, Xing-Yi Sarah
Sultana, Rehena
Tan, Joey Wee-Shan
Tan, Qiu Xuan
Wong, Jolene Si Min
Chia, Claramae Shulyn
Ong, Chin-Ann Johnny
author_facet Ong, Xing-Yi Sarah
Sultana, Rehena
Tan, Joey Wee-Shan
Tan, Qiu Xuan
Wong, Jolene Si Min
Chia, Claramae Shulyn
Ong, Chin-Ann Johnny
author_sort Ong, Xing-Yi Sarah
collection PubMed
description SIMPLE SUMMARY: Patients with peritoneal carcinomatosis often develop complications which prevent them from receiving adequate oral intake. This can contribute to malnutrition, as well as increased morbidity and mortality. In such patients, total parenteral nutrition, which involves the intravenous administration of nutrients thereby bypassing the oral route, can be lifesaving. In this study, we performed a systematic review and meta-analysis of the existing literature to evaluate the effect of total parenteral nutrition on the survival of patients with peritoneal carcinomatosis. In light of the limited treatment options available, total parenteral nutrition may improve survival outcomes, but further studies are needed to conclude definitively. ABSTRACT: Peritoneal carcinomatosis (PC) is often associated with malnutrition and an inability to tolerate enteral feeding. Although total parenteral nutrition (TPN) can be lifesaving for patients with no other means of nutritional support, its use in the management of PC patients remains controversial. Therefore, a systematic review and meta-analysis was performed to evaluate the benefit of TPN on the overall survival of PC patients, in accordance with PRISMA guidelines. A total of 187 articles were screened; 10 were included in this review and eight were included in the meta-analysis. The pooled median overall survival of patients who received TPN was significantly higher than patients who did not receive TPN (p = 0.040). When only high-quality studies were included, a significant survival advantage was observed in PC patients receiving TPN (p < 0.001). Subgroup analysis of patients receiving chemotherapy demonstrated a significant survival benefit (p = 0.008) associated with the use of TPN. In conclusion, TPN may improve survival outcomes in PC patients. However, further studies are needed to conclude more definitively on the effect of TPN.
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spelling pubmed-83937542021-08-28 The Role of Total Parenteral Nutrition in Patients with Peritoneal Carcinomatosis: A Systematic Review and Meta-Analysis Ong, Xing-Yi Sarah Sultana, Rehena Tan, Joey Wee-Shan Tan, Qiu Xuan Wong, Jolene Si Min Chia, Claramae Shulyn Ong, Chin-Ann Johnny Cancers (Basel) Systematic Review SIMPLE SUMMARY: Patients with peritoneal carcinomatosis often develop complications which prevent them from receiving adequate oral intake. This can contribute to malnutrition, as well as increased morbidity and mortality. In such patients, total parenteral nutrition, which involves the intravenous administration of nutrients thereby bypassing the oral route, can be lifesaving. In this study, we performed a systematic review and meta-analysis of the existing literature to evaluate the effect of total parenteral nutrition on the survival of patients with peritoneal carcinomatosis. In light of the limited treatment options available, total parenteral nutrition may improve survival outcomes, but further studies are needed to conclude definitively. ABSTRACT: Peritoneal carcinomatosis (PC) is often associated with malnutrition and an inability to tolerate enteral feeding. Although total parenteral nutrition (TPN) can be lifesaving for patients with no other means of nutritional support, its use in the management of PC patients remains controversial. Therefore, a systematic review and meta-analysis was performed to evaluate the benefit of TPN on the overall survival of PC patients, in accordance with PRISMA guidelines. A total of 187 articles were screened; 10 were included in this review and eight were included in the meta-analysis. The pooled median overall survival of patients who received TPN was significantly higher than patients who did not receive TPN (p = 0.040). When only high-quality studies were included, a significant survival advantage was observed in PC patients receiving TPN (p < 0.001). Subgroup analysis of patients receiving chemotherapy demonstrated a significant survival benefit (p = 0.008) associated with the use of TPN. In conclusion, TPN may improve survival outcomes in PC patients. However, further studies are needed to conclude more definitively on the effect of TPN. MDPI 2021-08-18 /pmc/articles/PMC8393754/ /pubmed/34439309 http://dx.doi.org/10.3390/cancers13164156 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Ong, Xing-Yi Sarah
Sultana, Rehena
Tan, Joey Wee-Shan
Tan, Qiu Xuan
Wong, Jolene Si Min
Chia, Claramae Shulyn
Ong, Chin-Ann Johnny
The Role of Total Parenteral Nutrition in Patients with Peritoneal Carcinomatosis: A Systematic Review and Meta-Analysis
title The Role of Total Parenteral Nutrition in Patients with Peritoneal Carcinomatosis: A Systematic Review and Meta-Analysis
title_full The Role of Total Parenteral Nutrition in Patients with Peritoneal Carcinomatosis: A Systematic Review and Meta-Analysis
title_fullStr The Role of Total Parenteral Nutrition in Patients with Peritoneal Carcinomatosis: A Systematic Review and Meta-Analysis
title_full_unstemmed The Role of Total Parenteral Nutrition in Patients with Peritoneal Carcinomatosis: A Systematic Review and Meta-Analysis
title_short The Role of Total Parenteral Nutrition in Patients with Peritoneal Carcinomatosis: A Systematic Review and Meta-Analysis
title_sort role of total parenteral nutrition in patients with peritoneal carcinomatosis: a systematic review and meta-analysis
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393754/
https://www.ncbi.nlm.nih.gov/pubmed/34439309
http://dx.doi.org/10.3390/cancers13164156
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