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Compounding Parenteral Products in Pediatric Wards—Effect of Environment and Aseptic Technique on Product Sterility
Parenteral products must be compounded using an aseptic technique to ensure sterility of the medicine. We compared the effect of three clinical environments as compounding areas as well as different aseptic techniques on the sterility of the compounded parenteral product. Clinical pharmacists and pe...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393854/ https://www.ncbi.nlm.nih.gov/pubmed/34442162 http://dx.doi.org/10.3390/healthcare9081025 |
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author | Virtanen, Sonja Kapp, Karmen Rautamo, Maria Schepel, Lotta Lindén-Lahti, Carita Cruz, Cristina D. Tammela, Päivi |
author_facet | Virtanen, Sonja Kapp, Karmen Rautamo, Maria Schepel, Lotta Lindén-Lahti, Carita Cruz, Cristina D. Tammela, Päivi |
author_sort | Virtanen, Sonja |
collection | PubMed |
description | Parenteral products must be compounded using an aseptic technique to ensure sterility of the medicine. We compared the effect of three clinical environments as compounding areas as well as different aseptic techniques on the sterility of the compounded parenteral product. Clinical pharmacists and pediatric nurses compounded 220 samples in total in three clinical environments: a patient room, a medicine room and biological safety cabinet. The study combined four methods: observation, environmental monitoring (settle plates), monitoring of personnel (finger dab plates) and sterility testing (membrane filtration). Of the compounded samples, 99% were sterile and no significant differences emerged between the clinical environments. Based on the settle plates, the biological safety cabinet was the only area that fulfilled the requirements for eliminating microbial contamination. Most of the steps on the observation form for aseptic techniques were followed. All participants disinfected their hands, wore gloves and disinfected the septum of the vial. Non-contaminated finger dab plates were mostly detected after compounding in the biological safety cabinet. Aseptic techniques were followed relatively well in all environments. However, these results emphasize the importance of good aseptic techniques and support the recommendation of compounding parenteral products in biological safety cabinets in clinical environments. |
format | Online Article Text |
id | pubmed-8393854 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83938542021-08-28 Compounding Parenteral Products in Pediatric Wards—Effect of Environment and Aseptic Technique on Product Sterility Virtanen, Sonja Kapp, Karmen Rautamo, Maria Schepel, Lotta Lindén-Lahti, Carita Cruz, Cristina D. Tammela, Päivi Healthcare (Basel) Article Parenteral products must be compounded using an aseptic technique to ensure sterility of the medicine. We compared the effect of three clinical environments as compounding areas as well as different aseptic techniques on the sterility of the compounded parenteral product. Clinical pharmacists and pediatric nurses compounded 220 samples in total in three clinical environments: a patient room, a medicine room and biological safety cabinet. The study combined four methods: observation, environmental monitoring (settle plates), monitoring of personnel (finger dab plates) and sterility testing (membrane filtration). Of the compounded samples, 99% were sterile and no significant differences emerged between the clinical environments. Based on the settle plates, the biological safety cabinet was the only area that fulfilled the requirements for eliminating microbial contamination. Most of the steps on the observation form for aseptic techniques were followed. All participants disinfected their hands, wore gloves and disinfected the septum of the vial. Non-contaminated finger dab plates were mostly detected after compounding in the biological safety cabinet. Aseptic techniques were followed relatively well in all environments. However, these results emphasize the importance of good aseptic techniques and support the recommendation of compounding parenteral products in biological safety cabinets in clinical environments. MDPI 2021-08-10 /pmc/articles/PMC8393854/ /pubmed/34442162 http://dx.doi.org/10.3390/healthcare9081025 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Virtanen, Sonja Kapp, Karmen Rautamo, Maria Schepel, Lotta Lindén-Lahti, Carita Cruz, Cristina D. Tammela, Päivi Compounding Parenteral Products in Pediatric Wards—Effect of Environment and Aseptic Technique on Product Sterility |
title | Compounding Parenteral Products in Pediatric Wards—Effect of Environment and Aseptic Technique on Product Sterility |
title_full | Compounding Parenteral Products in Pediatric Wards—Effect of Environment and Aseptic Technique on Product Sterility |
title_fullStr | Compounding Parenteral Products in Pediatric Wards—Effect of Environment and Aseptic Technique on Product Sterility |
title_full_unstemmed | Compounding Parenteral Products in Pediatric Wards—Effect of Environment and Aseptic Technique on Product Sterility |
title_short | Compounding Parenteral Products in Pediatric Wards—Effect of Environment and Aseptic Technique on Product Sterility |
title_sort | compounding parenteral products in pediatric wards—effect of environment and aseptic technique on product sterility |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393854/ https://www.ncbi.nlm.nih.gov/pubmed/34442162 http://dx.doi.org/10.3390/healthcare9081025 |
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