Cargando…

Compounding Parenteral Products in Pediatric Wards—Effect of Environment and Aseptic Technique on Product Sterility

Parenteral products must be compounded using an aseptic technique to ensure sterility of the medicine. We compared the effect of three clinical environments as compounding areas as well as different aseptic techniques on the sterility of the compounded parenteral product. Clinical pharmacists and pe...

Descripción completa

Detalles Bibliográficos
Autores principales: Virtanen, Sonja, Kapp, Karmen, Rautamo, Maria, Schepel, Lotta, Lindén-Lahti, Carita, Cruz, Cristina D., Tammela, Päivi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393854/
https://www.ncbi.nlm.nih.gov/pubmed/34442162
http://dx.doi.org/10.3390/healthcare9081025
_version_ 1783743819218419712
author Virtanen, Sonja
Kapp, Karmen
Rautamo, Maria
Schepel, Lotta
Lindén-Lahti, Carita
Cruz, Cristina D.
Tammela, Päivi
author_facet Virtanen, Sonja
Kapp, Karmen
Rautamo, Maria
Schepel, Lotta
Lindén-Lahti, Carita
Cruz, Cristina D.
Tammela, Päivi
author_sort Virtanen, Sonja
collection PubMed
description Parenteral products must be compounded using an aseptic technique to ensure sterility of the medicine. We compared the effect of three clinical environments as compounding areas as well as different aseptic techniques on the sterility of the compounded parenteral product. Clinical pharmacists and pediatric nurses compounded 220 samples in total in three clinical environments: a patient room, a medicine room and biological safety cabinet. The study combined four methods: observation, environmental monitoring (settle plates), monitoring of personnel (finger dab plates) and sterility testing (membrane filtration). Of the compounded samples, 99% were sterile and no significant differences emerged between the clinical environments. Based on the settle plates, the biological safety cabinet was the only area that fulfilled the requirements for eliminating microbial contamination. Most of the steps on the observation form for aseptic techniques were followed. All participants disinfected their hands, wore gloves and disinfected the septum of the vial. Non-contaminated finger dab plates were mostly detected after compounding in the biological safety cabinet. Aseptic techniques were followed relatively well in all environments. However, these results emphasize the importance of good aseptic techniques and support the recommendation of compounding parenteral products in biological safety cabinets in clinical environments.
format Online
Article
Text
id pubmed-8393854
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83938542021-08-28 Compounding Parenteral Products in Pediatric Wards—Effect of Environment and Aseptic Technique on Product Sterility Virtanen, Sonja Kapp, Karmen Rautamo, Maria Schepel, Lotta Lindén-Lahti, Carita Cruz, Cristina D. Tammela, Päivi Healthcare (Basel) Article Parenteral products must be compounded using an aseptic technique to ensure sterility of the medicine. We compared the effect of three clinical environments as compounding areas as well as different aseptic techniques on the sterility of the compounded parenteral product. Clinical pharmacists and pediatric nurses compounded 220 samples in total in three clinical environments: a patient room, a medicine room and biological safety cabinet. The study combined four methods: observation, environmental monitoring (settle plates), monitoring of personnel (finger dab plates) and sterility testing (membrane filtration). Of the compounded samples, 99% were sterile and no significant differences emerged between the clinical environments. Based on the settle plates, the biological safety cabinet was the only area that fulfilled the requirements for eliminating microbial contamination. Most of the steps on the observation form for aseptic techniques were followed. All participants disinfected their hands, wore gloves and disinfected the septum of the vial. Non-contaminated finger dab plates were mostly detected after compounding in the biological safety cabinet. Aseptic techniques were followed relatively well in all environments. However, these results emphasize the importance of good aseptic techniques and support the recommendation of compounding parenteral products in biological safety cabinets in clinical environments. MDPI 2021-08-10 /pmc/articles/PMC8393854/ /pubmed/34442162 http://dx.doi.org/10.3390/healthcare9081025 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Virtanen, Sonja
Kapp, Karmen
Rautamo, Maria
Schepel, Lotta
Lindén-Lahti, Carita
Cruz, Cristina D.
Tammela, Päivi
Compounding Parenteral Products in Pediatric Wards—Effect of Environment and Aseptic Technique on Product Sterility
title Compounding Parenteral Products in Pediatric Wards—Effect of Environment and Aseptic Technique on Product Sterility
title_full Compounding Parenteral Products in Pediatric Wards—Effect of Environment and Aseptic Technique on Product Sterility
title_fullStr Compounding Parenteral Products in Pediatric Wards—Effect of Environment and Aseptic Technique on Product Sterility
title_full_unstemmed Compounding Parenteral Products in Pediatric Wards—Effect of Environment and Aseptic Technique on Product Sterility
title_short Compounding Parenteral Products in Pediatric Wards—Effect of Environment and Aseptic Technique on Product Sterility
title_sort compounding parenteral products in pediatric wards—effect of environment and aseptic technique on product sterility
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393854/
https://www.ncbi.nlm.nih.gov/pubmed/34442162
http://dx.doi.org/10.3390/healthcare9081025
work_keys_str_mv AT virtanensonja compoundingparenteralproductsinpediatricwardseffectofenvironmentandaseptictechniqueonproductsterility
AT kappkarmen compoundingparenteralproductsinpediatricwardseffectofenvironmentandaseptictechniqueonproductsterility
AT rautamomaria compoundingparenteralproductsinpediatricwardseffectofenvironmentandaseptictechniqueonproductsterility
AT schepellotta compoundingparenteralproductsinpediatricwardseffectofenvironmentandaseptictechniqueonproductsterility
AT lindenlahticarita compoundingparenteralproductsinpediatricwardseffectofenvironmentandaseptictechniqueonproductsterility
AT cruzcristinad compoundingparenteralproductsinpediatricwardseffectofenvironmentandaseptictechniqueonproductsterility
AT tammelapaivi compoundingparenteralproductsinpediatricwardseffectofenvironmentandaseptictechniqueonproductsterility