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The Mechanisms of CHD8 in Neurodevelopment and Autism Spectrum Disorders

Chromodomain-helicase-DNA-binding protein 8 (CHD8) has been identified as one of the genes with the strongest association with autism. The CHD8 protein is a transcriptional regulator that is expressed in nearly all cell types and has been implicated in multiple cellular processes, including cell cyc...

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Detalles Bibliográficos
Autores principales: Weissberg, Orly, Elliott, Evan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393912/
https://www.ncbi.nlm.nih.gov/pubmed/34440307
http://dx.doi.org/10.3390/genes12081133
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author Weissberg, Orly
Elliott, Evan
author_facet Weissberg, Orly
Elliott, Evan
author_sort Weissberg, Orly
collection PubMed
description Chromodomain-helicase-DNA-binding protein 8 (CHD8) has been identified as one of the genes with the strongest association with autism. The CHD8 protein is a transcriptional regulator that is expressed in nearly all cell types and has been implicated in multiple cellular processes, including cell cycle, cell adhesion, neuronal development, myelination, and synaptogenesis. Considering the central role of CHD8 in the genetics of autism, a deeper understanding of the physiological functions of CHD8 is important to understand the development of the autism phenotype and potential therapeutic targets. Different CHD8 mutant mouse models were developed to determine autism-like phenotypes and to fully understand their mechanisms. Here, we review the current knowledge on CHD8, with an emphasis on mechanistic lessons gained from animal models that have been studied.
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spelling pubmed-83939122021-08-28 The Mechanisms of CHD8 in Neurodevelopment and Autism Spectrum Disorders Weissberg, Orly Elliott, Evan Genes (Basel) Review Chromodomain-helicase-DNA-binding protein 8 (CHD8) has been identified as one of the genes with the strongest association with autism. The CHD8 protein is a transcriptional regulator that is expressed in nearly all cell types and has been implicated in multiple cellular processes, including cell cycle, cell adhesion, neuronal development, myelination, and synaptogenesis. Considering the central role of CHD8 in the genetics of autism, a deeper understanding of the physiological functions of CHD8 is important to understand the development of the autism phenotype and potential therapeutic targets. Different CHD8 mutant mouse models were developed to determine autism-like phenotypes and to fully understand their mechanisms. Here, we review the current knowledge on CHD8, with an emphasis on mechanistic lessons gained from animal models that have been studied. MDPI 2021-07-26 /pmc/articles/PMC8393912/ /pubmed/34440307 http://dx.doi.org/10.3390/genes12081133 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Weissberg, Orly
Elliott, Evan
The Mechanisms of CHD8 in Neurodevelopment and Autism Spectrum Disorders
title The Mechanisms of CHD8 in Neurodevelopment and Autism Spectrum Disorders
title_full The Mechanisms of CHD8 in Neurodevelopment and Autism Spectrum Disorders
title_fullStr The Mechanisms of CHD8 in Neurodevelopment and Autism Spectrum Disorders
title_full_unstemmed The Mechanisms of CHD8 in Neurodevelopment and Autism Spectrum Disorders
title_short The Mechanisms of CHD8 in Neurodevelopment and Autism Spectrum Disorders
title_sort mechanisms of chd8 in neurodevelopment and autism spectrum disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393912/
https://www.ncbi.nlm.nih.gov/pubmed/34440307
http://dx.doi.org/10.3390/genes12081133
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