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The Mechanisms of CHD8 in Neurodevelopment and Autism Spectrum Disorders
Chromodomain-helicase-DNA-binding protein 8 (CHD8) has been identified as one of the genes with the strongest association with autism. The CHD8 protein is a transcriptional regulator that is expressed in nearly all cell types and has been implicated in multiple cellular processes, including cell cyc...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393912/ https://www.ncbi.nlm.nih.gov/pubmed/34440307 http://dx.doi.org/10.3390/genes12081133 |
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author | Weissberg, Orly Elliott, Evan |
author_facet | Weissberg, Orly Elliott, Evan |
author_sort | Weissberg, Orly |
collection | PubMed |
description | Chromodomain-helicase-DNA-binding protein 8 (CHD8) has been identified as one of the genes with the strongest association with autism. The CHD8 protein is a transcriptional regulator that is expressed in nearly all cell types and has been implicated in multiple cellular processes, including cell cycle, cell adhesion, neuronal development, myelination, and synaptogenesis. Considering the central role of CHD8 in the genetics of autism, a deeper understanding of the physiological functions of CHD8 is important to understand the development of the autism phenotype and potential therapeutic targets. Different CHD8 mutant mouse models were developed to determine autism-like phenotypes and to fully understand their mechanisms. Here, we review the current knowledge on CHD8, with an emphasis on mechanistic lessons gained from animal models that have been studied. |
format | Online Article Text |
id | pubmed-8393912 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83939122021-08-28 The Mechanisms of CHD8 in Neurodevelopment and Autism Spectrum Disorders Weissberg, Orly Elliott, Evan Genes (Basel) Review Chromodomain-helicase-DNA-binding protein 8 (CHD8) has been identified as one of the genes with the strongest association with autism. The CHD8 protein is a transcriptional regulator that is expressed in nearly all cell types and has been implicated in multiple cellular processes, including cell cycle, cell adhesion, neuronal development, myelination, and synaptogenesis. Considering the central role of CHD8 in the genetics of autism, a deeper understanding of the physiological functions of CHD8 is important to understand the development of the autism phenotype and potential therapeutic targets. Different CHD8 mutant mouse models were developed to determine autism-like phenotypes and to fully understand their mechanisms. Here, we review the current knowledge on CHD8, with an emphasis on mechanistic lessons gained from animal models that have been studied. MDPI 2021-07-26 /pmc/articles/PMC8393912/ /pubmed/34440307 http://dx.doi.org/10.3390/genes12081133 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Weissberg, Orly Elliott, Evan The Mechanisms of CHD8 in Neurodevelopment and Autism Spectrum Disorders |
title | The Mechanisms of CHD8 in Neurodevelopment and Autism Spectrum Disorders |
title_full | The Mechanisms of CHD8 in Neurodevelopment and Autism Spectrum Disorders |
title_fullStr | The Mechanisms of CHD8 in Neurodevelopment and Autism Spectrum Disorders |
title_full_unstemmed | The Mechanisms of CHD8 in Neurodevelopment and Autism Spectrum Disorders |
title_short | The Mechanisms of CHD8 in Neurodevelopment and Autism Spectrum Disorders |
title_sort | mechanisms of chd8 in neurodevelopment and autism spectrum disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393912/ https://www.ncbi.nlm.nih.gov/pubmed/34440307 http://dx.doi.org/10.3390/genes12081133 |
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