Enzymatic Spermine Metabolites Induce Apoptosis Associated with Increase of p53, caspase-3 and miR-34a in Both Neuroblastoma Cells, SJNKP and the N-Myc-Amplified Form IMR5

Neuroblastoma (NB) is a common malignant solid tumor in children and accounts for 15% of childhood cancer mortality. Amplification of the N-Myc oncogene is a well-established poor prognostic marker in NB patients and strongly correlates with higher tumor aggression and resistance to treatment. New t...

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Detalles Bibliográficos
Autores principales: Kanamori, Yuta, Finotti, Alessia, Di Magno, Laura, Canettieri, Gianluca, Tahara, Tomoaki, Timeus, Fabio, Greco, Antonio, Tirassa, Paola, Gasparello, Jessica, Fino, Pasquale, Di Liegro, Carlo Maria, Proia, Patrizia, Schiera, Gabriella, Di Liegro, Italia, Gambari, Roberto, Agostinelli, Enzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393918/
https://www.ncbi.nlm.nih.gov/pubmed/34440719
http://dx.doi.org/10.3390/cells10081950

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