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Roles for α-Synuclein in Gene Expression
α-Synuclein (α-Syn) is a small cytosolic protein associated with a range of cellular compartments, including synaptic vesicles, the nucleus, mitochondria, endoplasmic reticulum, Golgi apparatus, and lysosomes. In addition to its physiological role in regulating presynaptic function, the protein play...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393936/ https://www.ncbi.nlm.nih.gov/pubmed/34440340 http://dx.doi.org/10.3390/genes12081166 |
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author | Somayaji, Mahalakshmi Lanseur, Zina Choi, Se Joon Sulzer, David Mosharov, Eugene V. |
author_facet | Somayaji, Mahalakshmi Lanseur, Zina Choi, Se Joon Sulzer, David Mosharov, Eugene V. |
author_sort | Somayaji, Mahalakshmi |
collection | PubMed |
description | α-Synuclein (α-Syn) is a small cytosolic protein associated with a range of cellular compartments, including synaptic vesicles, the nucleus, mitochondria, endoplasmic reticulum, Golgi apparatus, and lysosomes. In addition to its physiological role in regulating presynaptic function, the protein plays a central role in both sporadic and familial Parkinson’s disease (PD) via a gain-of-function mechanism. Because of this, several recent strategies propose to decrease α-Syn levels in PD patients. While these therapies may offer breakthroughs in PD management, the normal functions of α-Syn and potential side effects of its depletion require careful evaluation. Here, we review recent evidence on physiological and pathological roles of α-Syn in regulating activity-dependent signal transduction and gene expression pathways that play fundamental role in synaptic plasticity. |
format | Online Article Text |
id | pubmed-8393936 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83939362021-08-28 Roles for α-Synuclein in Gene Expression Somayaji, Mahalakshmi Lanseur, Zina Choi, Se Joon Sulzer, David Mosharov, Eugene V. Genes (Basel) Review α-Synuclein (α-Syn) is a small cytosolic protein associated with a range of cellular compartments, including synaptic vesicles, the nucleus, mitochondria, endoplasmic reticulum, Golgi apparatus, and lysosomes. In addition to its physiological role in regulating presynaptic function, the protein plays a central role in both sporadic and familial Parkinson’s disease (PD) via a gain-of-function mechanism. Because of this, several recent strategies propose to decrease α-Syn levels in PD patients. While these therapies may offer breakthroughs in PD management, the normal functions of α-Syn and potential side effects of its depletion require careful evaluation. Here, we review recent evidence on physiological and pathological roles of α-Syn in regulating activity-dependent signal transduction and gene expression pathways that play fundamental role in synaptic plasticity. MDPI 2021-07-29 /pmc/articles/PMC8393936/ /pubmed/34440340 http://dx.doi.org/10.3390/genes12081166 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Somayaji, Mahalakshmi Lanseur, Zina Choi, Se Joon Sulzer, David Mosharov, Eugene V. Roles for α-Synuclein in Gene Expression |
title | Roles for α-Synuclein in Gene Expression |
title_full | Roles for α-Synuclein in Gene Expression |
title_fullStr | Roles for α-Synuclein in Gene Expression |
title_full_unstemmed | Roles for α-Synuclein in Gene Expression |
title_short | Roles for α-Synuclein in Gene Expression |
title_sort | roles for α-synuclein in gene expression |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393936/ https://www.ncbi.nlm.nih.gov/pubmed/34440340 http://dx.doi.org/10.3390/genes12081166 |
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