Cargando…

Roles for α-Synuclein in Gene Expression

α-Synuclein (α-Syn) is a small cytosolic protein associated with a range of cellular compartments, including synaptic vesicles, the nucleus, mitochondria, endoplasmic reticulum, Golgi apparatus, and lysosomes. In addition to its physiological role in regulating presynaptic function, the protein play...

Descripción completa

Detalles Bibliográficos
Autores principales: Somayaji, Mahalakshmi, Lanseur, Zina, Choi, Se Joon, Sulzer, David, Mosharov, Eugene V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393936/
https://www.ncbi.nlm.nih.gov/pubmed/34440340
http://dx.doi.org/10.3390/genes12081166
_version_ 1783743837214081024
author Somayaji, Mahalakshmi
Lanseur, Zina
Choi, Se Joon
Sulzer, David
Mosharov, Eugene V.
author_facet Somayaji, Mahalakshmi
Lanseur, Zina
Choi, Se Joon
Sulzer, David
Mosharov, Eugene V.
author_sort Somayaji, Mahalakshmi
collection PubMed
description α-Synuclein (α-Syn) is a small cytosolic protein associated with a range of cellular compartments, including synaptic vesicles, the nucleus, mitochondria, endoplasmic reticulum, Golgi apparatus, and lysosomes. In addition to its physiological role in regulating presynaptic function, the protein plays a central role in both sporadic and familial Parkinson’s disease (PD) via a gain-of-function mechanism. Because of this, several recent strategies propose to decrease α-Syn levels in PD patients. While these therapies may offer breakthroughs in PD management, the normal functions of α-Syn and potential side effects of its depletion require careful evaluation. Here, we review recent evidence on physiological and pathological roles of α-Syn in regulating activity-dependent signal transduction and gene expression pathways that play fundamental role in synaptic plasticity.
format Online
Article
Text
id pubmed-8393936
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83939362021-08-28 Roles for α-Synuclein in Gene Expression Somayaji, Mahalakshmi Lanseur, Zina Choi, Se Joon Sulzer, David Mosharov, Eugene V. Genes (Basel) Review α-Synuclein (α-Syn) is a small cytosolic protein associated with a range of cellular compartments, including synaptic vesicles, the nucleus, mitochondria, endoplasmic reticulum, Golgi apparatus, and lysosomes. In addition to its physiological role in regulating presynaptic function, the protein plays a central role in both sporadic and familial Parkinson’s disease (PD) via a gain-of-function mechanism. Because of this, several recent strategies propose to decrease α-Syn levels in PD patients. While these therapies may offer breakthroughs in PD management, the normal functions of α-Syn and potential side effects of its depletion require careful evaluation. Here, we review recent evidence on physiological and pathological roles of α-Syn in regulating activity-dependent signal transduction and gene expression pathways that play fundamental role in synaptic plasticity. MDPI 2021-07-29 /pmc/articles/PMC8393936/ /pubmed/34440340 http://dx.doi.org/10.3390/genes12081166 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Somayaji, Mahalakshmi
Lanseur, Zina
Choi, Se Joon
Sulzer, David
Mosharov, Eugene V.
Roles for α-Synuclein in Gene Expression
title Roles for α-Synuclein in Gene Expression
title_full Roles for α-Synuclein in Gene Expression
title_fullStr Roles for α-Synuclein in Gene Expression
title_full_unstemmed Roles for α-Synuclein in Gene Expression
title_short Roles for α-Synuclein in Gene Expression
title_sort roles for α-synuclein in gene expression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393936/
https://www.ncbi.nlm.nih.gov/pubmed/34440340
http://dx.doi.org/10.3390/genes12081166
work_keys_str_mv AT somayajimahalakshmi rolesforasynucleiningeneexpression
AT lanseurzina rolesforasynucleiningeneexpression
AT choisejoon rolesforasynucleiningeneexpression
AT sulzerdavid rolesforasynucleiningeneexpression
AT mosharoveugenev rolesforasynucleiningeneexpression