The Role of Galectin-3 and ST2 in Cardiology: A Short Review

Galectin-3 is a lectin that binds beta-galactosides. It is involved in cardiac remodeling and fibrosis through the activation of macrophages and fibroblasts. ST2 is secreted by myocardial cells due to cardiac overload. These two biomarkers have been traditionally studied in the field of heart failur...

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Autores principales: Merino-Merino, Ana, Gonzalez-Bernal, Jeronimo, Fernandez-Zoppino, Dario, Saez-Maleta, Ruth, Perez-Rivera, Jose-Angel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393977/
https://www.ncbi.nlm.nih.gov/pubmed/34439833
http://dx.doi.org/10.3390/biom11081167
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author Merino-Merino, Ana
Gonzalez-Bernal, Jeronimo
Fernandez-Zoppino, Dario
Saez-Maleta, Ruth
Perez-Rivera, Jose-Angel
author_facet Merino-Merino, Ana
Gonzalez-Bernal, Jeronimo
Fernandez-Zoppino, Dario
Saez-Maleta, Ruth
Perez-Rivera, Jose-Angel
author_sort Merino-Merino, Ana
collection PubMed
description Galectin-3 is a lectin that binds beta-galactosides. It is involved in cardiac remodeling and fibrosis through the activation of macrophages and fibroblasts. ST2 is secreted by myocardial cells due to cardiac overload. These two biomarkers have been traditionally studied in the field of heart failure to guide medical therapy and detect the progression of the disease. Nevertheless, there are novel evidences that connect galectin-3 and ST2 with coronary heart disease and, specifically, with atrial fibrillation. The aim of this article is to concisely review the diagnostic and prognostic role of galectin-3 and ST2 in different cardiac diseases.
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spelling pubmed-83939772021-08-28 The Role of Galectin-3 and ST2 in Cardiology: A Short Review Merino-Merino, Ana Gonzalez-Bernal, Jeronimo Fernandez-Zoppino, Dario Saez-Maleta, Ruth Perez-Rivera, Jose-Angel Biomolecules Review Galectin-3 is a lectin that binds beta-galactosides. It is involved in cardiac remodeling and fibrosis through the activation of macrophages and fibroblasts. ST2 is secreted by myocardial cells due to cardiac overload. These two biomarkers have been traditionally studied in the field of heart failure to guide medical therapy and detect the progression of the disease. Nevertheless, there are novel evidences that connect galectin-3 and ST2 with coronary heart disease and, specifically, with atrial fibrillation. The aim of this article is to concisely review the diagnostic and prognostic role of galectin-3 and ST2 in different cardiac diseases. MDPI 2021-08-07 /pmc/articles/PMC8393977/ /pubmed/34439833 http://dx.doi.org/10.3390/biom11081167 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Merino-Merino, Ana
Gonzalez-Bernal, Jeronimo
Fernandez-Zoppino, Dario
Saez-Maleta, Ruth
Perez-Rivera, Jose-Angel
The Role of Galectin-3 and ST2 in Cardiology: A Short Review
title The Role of Galectin-3 and ST2 in Cardiology: A Short Review
title_full The Role of Galectin-3 and ST2 in Cardiology: A Short Review
title_fullStr The Role of Galectin-3 and ST2 in Cardiology: A Short Review
title_full_unstemmed The Role of Galectin-3 and ST2 in Cardiology: A Short Review
title_short The Role of Galectin-3 and ST2 in Cardiology: A Short Review
title_sort role of galectin-3 and st2 in cardiology: a short review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393977/
https://www.ncbi.nlm.nih.gov/pubmed/34439833
http://dx.doi.org/10.3390/biom11081167
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