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Stability of OCT and OCTA in the Intensive Therapy Unit Setting
To assess the stability of retinal structure and blood flow measures over time and in different clinical settings using portable optical coherence tomography angiography (OCTA) as a potential biomarker of central perfusion in critical illness, 18 oesophagectomy patients completed retinal structure a...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394026/ https://www.ncbi.nlm.nih.gov/pubmed/34441449 http://dx.doi.org/10.3390/diagnostics11081516 |
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author | Courtie, Ella F. Kale, Aditya U. Hui, Benjamin T. K. Liu, Xiaoxuan Capewell, Nicholas I. Bishop, Jonathan R. B. Whitehouse, Tony Veenith, Tonny Logan, Ann Denniston, Alastair K. Blanch, Richard J. |
author_facet | Courtie, Ella F. Kale, Aditya U. Hui, Benjamin T. K. Liu, Xiaoxuan Capewell, Nicholas I. Bishop, Jonathan R. B. Whitehouse, Tony Veenith, Tonny Logan, Ann Denniston, Alastair K. Blanch, Richard J. |
author_sort | Courtie, Ella F. |
collection | PubMed |
description | To assess the stability of retinal structure and blood flow measures over time and in different clinical settings using portable optical coherence tomography angiography (OCTA) as a potential biomarker of central perfusion in critical illness, 18 oesophagectomy patients completed retinal structure and blood flow measurements by portable OCT and OCTA in the eye clinic and intensive therapy unit (ITU) across three timepoints: (1) pre-operation in a clinic setting; (2) 24–48 h post-operation during ITU admission; and (3) seven days post-operation, if the patient was still admitted. Blood flow and macular structural measures were stable between the examination settings, with no consistent variation between pre- and post-operation scans, while retinal nerve fibre layer thickness increased in the post-operative scans (+2.31 µm, p = 0.001). Foveal avascular zone (FAZ) measurements were the most stable, with an intraclass correlation coefficient of up to 0.92 for right eye FAZ area. Blood flow and structural measures were lower in left eyes than right eyes. Retinal blood flow assessed in patients before and during an ITU stay using portable OCTA showed no systematic differences between the clinical settings. The stability of retinal blood flow measures suggests the potential for portable OCTA to provide clinically useful measures in ITU patients. |
format | Online Article Text |
id | pubmed-8394026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83940262021-08-28 Stability of OCT and OCTA in the Intensive Therapy Unit Setting Courtie, Ella F. Kale, Aditya U. Hui, Benjamin T. K. Liu, Xiaoxuan Capewell, Nicholas I. Bishop, Jonathan R. B. Whitehouse, Tony Veenith, Tonny Logan, Ann Denniston, Alastair K. Blanch, Richard J. Diagnostics (Basel) Article To assess the stability of retinal structure and blood flow measures over time and in different clinical settings using portable optical coherence tomography angiography (OCTA) as a potential biomarker of central perfusion in critical illness, 18 oesophagectomy patients completed retinal structure and blood flow measurements by portable OCT and OCTA in the eye clinic and intensive therapy unit (ITU) across three timepoints: (1) pre-operation in a clinic setting; (2) 24–48 h post-operation during ITU admission; and (3) seven days post-operation, if the patient was still admitted. Blood flow and macular structural measures were stable between the examination settings, with no consistent variation between pre- and post-operation scans, while retinal nerve fibre layer thickness increased in the post-operative scans (+2.31 µm, p = 0.001). Foveal avascular zone (FAZ) measurements were the most stable, with an intraclass correlation coefficient of up to 0.92 for right eye FAZ area. Blood flow and structural measures were lower in left eyes than right eyes. Retinal blood flow assessed in patients before and during an ITU stay using portable OCTA showed no systematic differences between the clinical settings. The stability of retinal blood flow measures suggests the potential for portable OCTA to provide clinically useful measures in ITU patients. MDPI 2021-08-23 /pmc/articles/PMC8394026/ /pubmed/34441449 http://dx.doi.org/10.3390/diagnostics11081516 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Courtie, Ella F. Kale, Aditya U. Hui, Benjamin T. K. Liu, Xiaoxuan Capewell, Nicholas I. Bishop, Jonathan R. B. Whitehouse, Tony Veenith, Tonny Logan, Ann Denniston, Alastair K. Blanch, Richard J. Stability of OCT and OCTA in the Intensive Therapy Unit Setting |
title | Stability of OCT and OCTA in the Intensive Therapy Unit Setting |
title_full | Stability of OCT and OCTA in the Intensive Therapy Unit Setting |
title_fullStr | Stability of OCT and OCTA in the Intensive Therapy Unit Setting |
title_full_unstemmed | Stability of OCT and OCTA in the Intensive Therapy Unit Setting |
title_short | Stability of OCT and OCTA in the Intensive Therapy Unit Setting |
title_sort | stability of oct and octa in the intensive therapy unit setting |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394026/ https://www.ncbi.nlm.nih.gov/pubmed/34441449 http://dx.doi.org/10.3390/diagnostics11081516 |
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