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Stability of OCT and OCTA in the Intensive Therapy Unit Setting

To assess the stability of retinal structure and blood flow measures over time and in different clinical settings using portable optical coherence tomography angiography (OCTA) as a potential biomarker of central perfusion in critical illness, 18 oesophagectomy patients completed retinal structure a...

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Autores principales: Courtie, Ella F., Kale, Aditya U., Hui, Benjamin T. K., Liu, Xiaoxuan, Capewell, Nicholas I., Bishop, Jonathan R. B., Whitehouse, Tony, Veenith, Tonny, Logan, Ann, Denniston, Alastair K., Blanch, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394026/
https://www.ncbi.nlm.nih.gov/pubmed/34441449
http://dx.doi.org/10.3390/diagnostics11081516
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author Courtie, Ella F.
Kale, Aditya U.
Hui, Benjamin T. K.
Liu, Xiaoxuan
Capewell, Nicholas I.
Bishop, Jonathan R. B.
Whitehouse, Tony
Veenith, Tonny
Logan, Ann
Denniston, Alastair K.
Blanch, Richard J.
author_facet Courtie, Ella F.
Kale, Aditya U.
Hui, Benjamin T. K.
Liu, Xiaoxuan
Capewell, Nicholas I.
Bishop, Jonathan R. B.
Whitehouse, Tony
Veenith, Tonny
Logan, Ann
Denniston, Alastair K.
Blanch, Richard J.
author_sort Courtie, Ella F.
collection PubMed
description To assess the stability of retinal structure and blood flow measures over time and in different clinical settings using portable optical coherence tomography angiography (OCTA) as a potential biomarker of central perfusion in critical illness, 18 oesophagectomy patients completed retinal structure and blood flow measurements by portable OCT and OCTA in the eye clinic and intensive therapy unit (ITU) across three timepoints: (1) pre-operation in a clinic setting; (2) 24–48 h post-operation during ITU admission; and (3) seven days post-operation, if the patient was still admitted. Blood flow and macular structural measures were stable between the examination settings, with no consistent variation between pre- and post-operation scans, while retinal nerve fibre layer thickness increased in the post-operative scans (+2.31 µm, p = 0.001). Foveal avascular zone (FAZ) measurements were the most stable, with an intraclass correlation coefficient of up to 0.92 for right eye FAZ area. Blood flow and structural measures were lower in left eyes than right eyes. Retinal blood flow assessed in patients before and during an ITU stay using portable OCTA showed no systematic differences between the clinical settings. The stability of retinal blood flow measures suggests the potential for portable OCTA to provide clinically useful measures in ITU patients.
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spelling pubmed-83940262021-08-28 Stability of OCT and OCTA in the Intensive Therapy Unit Setting Courtie, Ella F. Kale, Aditya U. Hui, Benjamin T. K. Liu, Xiaoxuan Capewell, Nicholas I. Bishop, Jonathan R. B. Whitehouse, Tony Veenith, Tonny Logan, Ann Denniston, Alastair K. Blanch, Richard J. Diagnostics (Basel) Article To assess the stability of retinal structure and blood flow measures over time and in different clinical settings using portable optical coherence tomography angiography (OCTA) as a potential biomarker of central perfusion in critical illness, 18 oesophagectomy patients completed retinal structure and blood flow measurements by portable OCT and OCTA in the eye clinic and intensive therapy unit (ITU) across three timepoints: (1) pre-operation in a clinic setting; (2) 24–48 h post-operation during ITU admission; and (3) seven days post-operation, if the patient was still admitted. Blood flow and macular structural measures were stable between the examination settings, with no consistent variation between pre- and post-operation scans, while retinal nerve fibre layer thickness increased in the post-operative scans (+2.31 µm, p = 0.001). Foveal avascular zone (FAZ) measurements were the most stable, with an intraclass correlation coefficient of up to 0.92 for right eye FAZ area. Blood flow and structural measures were lower in left eyes than right eyes. Retinal blood flow assessed in patients before and during an ITU stay using portable OCTA showed no systematic differences between the clinical settings. The stability of retinal blood flow measures suggests the potential for portable OCTA to provide clinically useful measures in ITU patients. MDPI 2021-08-23 /pmc/articles/PMC8394026/ /pubmed/34441449 http://dx.doi.org/10.3390/diagnostics11081516 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Courtie, Ella F.
Kale, Aditya U.
Hui, Benjamin T. K.
Liu, Xiaoxuan
Capewell, Nicholas I.
Bishop, Jonathan R. B.
Whitehouse, Tony
Veenith, Tonny
Logan, Ann
Denniston, Alastair K.
Blanch, Richard J.
Stability of OCT and OCTA in the Intensive Therapy Unit Setting
title Stability of OCT and OCTA in the Intensive Therapy Unit Setting
title_full Stability of OCT and OCTA in the Intensive Therapy Unit Setting
title_fullStr Stability of OCT and OCTA in the Intensive Therapy Unit Setting
title_full_unstemmed Stability of OCT and OCTA in the Intensive Therapy Unit Setting
title_short Stability of OCT and OCTA in the Intensive Therapy Unit Setting
title_sort stability of oct and octa in the intensive therapy unit setting
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394026/
https://www.ncbi.nlm.nih.gov/pubmed/34441449
http://dx.doi.org/10.3390/diagnostics11081516
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