Cytocidal Antitumor Effects against Human Ovarian Cancer Cells Induced by B-Lactam Steroid Alkylators with Targeted Activity against Poly (ADP-Ribose) Polymerase (PARP) Enzymes in a Cell-Free Assay

We evaluated three newly synthesized B-lactam hybrid homo-aza-steroidal alkylators (ASA-A, ASA-B and ASA-C) for their PARP1/2 inhibition activity and their DNA damaging effect against human ovarian carcinoma cells. These agents are conjugated with an alkylating component (POPA), which also served as...

Descripción completa

Detalles Bibliográficos
Autores principales: Nikoleousakos, Nikolaos, Dalezis, Panagiotis, Polonifi, Aikaterini, Geromichalou, Elena G., Sagredou, Sofia, Alifieris, Constantinos E., Deligiorgi, Maria V., Sarli, Vasiliki, Trafalis, Dimitrios T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394033/
https://www.ncbi.nlm.nih.gov/pubmed/34440232
http://dx.doi.org/10.3390/biomedicines9081028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394033/
https://www.ncbi.nlm.nih.gov/pubmed/34440232
http://dx.doi.org/10.3390/biomedicines9081028

Ejemplares similares