The Bacterial Enzyme RfxCas13d Is Less Neurotoxic Than PspCas13b and Could Be a Promising RNA Editing and Interference Tool in the Nervous System

RNA therapies using RNA editing and interference are currently being developed for neurological diseases. The CRISPR-Cas13 system, based on bacterial enzymes, holds great promise for developing efficient tools for RNA therapies. However, neurotoxic activity has been reported for Cas13a, and recent s...

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Detalles Bibliográficos
Autores principales: Wu, Qin-Wei, Kapfhammer, Josef P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394060/
https://www.ncbi.nlm.nih.gov/pubmed/34439673
http://dx.doi.org/10.3390/brainsci11081054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394060/
https://www.ncbi.nlm.nih.gov/pubmed/34439673
http://dx.doi.org/10.3390/brainsci11081054

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