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Integral Membrane Protein 2A Is a Negative Regulator of Canonical and Non-Canonical Hedgehog Signalling

The Hedgehog (Hh) receptor PTCH1 and the integral membrane protein 2A (ITM2A) inhibit autophagy by reducing autolysosome formation. In this study, we demonstrate that ITM2A physically interacts with PTCH1; however, the two proteins inhibit autophagic flux independently, since silencing of ITM2A did...

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Detalles Bibliográficos
Autores principales:	Morales-Alcala, Cintli C., Georgiou, Ioanna Ch., Timmis, Alex J., Riobo-Del Galdo, Natalia A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394137/ https://www.ncbi.nlm.nih.gov/pubmed/34440772 http://dx.doi.org/10.3390/cells10082003

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