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Acute kidney injury caused by venomous animals: inflammatory mechanisms

Either bites or stings of venomous animals comprise relevant public health problems in tropical countries. Acute kidney injury (AKI) induced by animal toxins is related to worse prognostic and outcomes. Being one the most important pathways to induce AKI following envenoming due to animal toxins, in...

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Autores principales: de Oliveira, Naila Albertina, Cardoso, Simone Cristina, Barbosa, Dulce Aparecida, da Fonseca, Cassiane Dezoti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394371/
https://www.ncbi.nlm.nih.gov/pubmed/34512738
http://dx.doi.org/10.1590/1678-9199-JVATITD-2020-0189
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author de Oliveira, Naila Albertina
Cardoso, Simone Cristina
Barbosa, Dulce Aparecida
da Fonseca, Cassiane Dezoti
author_facet de Oliveira, Naila Albertina
Cardoso, Simone Cristina
Barbosa, Dulce Aparecida
da Fonseca, Cassiane Dezoti
author_sort de Oliveira, Naila Albertina
collection PubMed
description Either bites or stings of venomous animals comprise relevant public health problems in tropical countries. Acute kidney injury (AKI) induced by animal toxins is related to worse prognostic and outcomes. Being one the most important pathways to induce AKI following envenoming due to animal toxins, inflammation is an essential biological response that eliminates pathogenic bacteria and repairs tissue after injury. However, direct nephrotoxicity (i.e. apoptotic and necrotic mechanisms of toxins), pigmenturia (i.e. rhabdomyolysis and hemolysis), anaphylactic reactions, and coagulopathies could contribute to the renal injury. All these mechanisms are closely integrated, but inflammation is a distinct process. Hence, it is important to improve our understanding on inflammation mechanisms of these syndromes to provide a promising outlook to reduce morbidity and mortality. This literature review highlights the main scientific evidence of acute kidney injury induced by bites or stings from venomous animals and their inflammatory mechanisms. It included observational, cross-sectional, case-control and cohort human studies available up to December 2019. Descriptors were used according to Medical Subject Headings (MeSH), namely: “Acute kidney injury” or “Venom” and “Inflammation” on Medline/Pubmed and Google Scholar; “Kidney disease” or “Acute kidney injury” on Lilacs and SciELO. The present review evidenced that, among the described forms of renal inflammation, it can occur either directly or indirectly on renal cells by means of intravascular, systemic and endothelial hemolysis, activation of inflammatory pathway, as well as direct action of venom cytotoxic components on kidney structures.
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spelling pubmed-83943712021-09-09 Acute kidney injury caused by venomous animals: inflammatory mechanisms de Oliveira, Naila Albertina Cardoso, Simone Cristina Barbosa, Dulce Aparecida da Fonseca, Cassiane Dezoti J Venom Anim Toxins Incl Trop Dis Review Either bites or stings of venomous animals comprise relevant public health problems in tropical countries. Acute kidney injury (AKI) induced by animal toxins is related to worse prognostic and outcomes. Being one the most important pathways to induce AKI following envenoming due to animal toxins, inflammation is an essential biological response that eliminates pathogenic bacteria and repairs tissue after injury. However, direct nephrotoxicity (i.e. apoptotic and necrotic mechanisms of toxins), pigmenturia (i.e. rhabdomyolysis and hemolysis), anaphylactic reactions, and coagulopathies could contribute to the renal injury. All these mechanisms are closely integrated, but inflammation is a distinct process. Hence, it is important to improve our understanding on inflammation mechanisms of these syndromes to provide a promising outlook to reduce morbidity and mortality. This literature review highlights the main scientific evidence of acute kidney injury induced by bites or stings from venomous animals and their inflammatory mechanisms. It included observational, cross-sectional, case-control and cohort human studies available up to December 2019. Descriptors were used according to Medical Subject Headings (MeSH), namely: “Acute kidney injury” or “Venom” and “Inflammation” on Medline/Pubmed and Google Scholar; “Kidney disease” or “Acute kidney injury” on Lilacs and SciELO. The present review evidenced that, among the described forms of renal inflammation, it can occur either directly or indirectly on renal cells by means of intravascular, systemic and endothelial hemolysis, activation of inflammatory pathway, as well as direct action of venom cytotoxic components on kidney structures. Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) 2021-08-25 /pmc/articles/PMC8394371/ /pubmed/34512738 http://dx.doi.org/10.1590/1678-9199-JVATITD-2020-0189 Text en https://creativecommons.org/licenses/by/4.0/© The Author(s). 2021 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (https://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
de Oliveira, Naila Albertina
Cardoso, Simone Cristina
Barbosa, Dulce Aparecida
da Fonseca, Cassiane Dezoti
Acute kidney injury caused by venomous animals: inflammatory mechanisms
title Acute kidney injury caused by venomous animals: inflammatory mechanisms
title_full Acute kidney injury caused by venomous animals: inflammatory mechanisms
title_fullStr Acute kidney injury caused by venomous animals: inflammatory mechanisms
title_full_unstemmed Acute kidney injury caused by venomous animals: inflammatory mechanisms
title_short Acute kidney injury caused by venomous animals: inflammatory mechanisms
title_sort acute kidney injury caused by venomous animals: inflammatory mechanisms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394371/
https://www.ncbi.nlm.nih.gov/pubmed/34512738
http://dx.doi.org/10.1590/1678-9199-JVATITD-2020-0189
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