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Assessment of Cardiovascular Risk in Women with Periodontal Diseases According to C-reactive Protein Levels
Cardiovascular diseases (CVD) are highly prevalent non-communicable diseases worldwide. Periodontitis may act as a non-traditional cardiovascular risk (CVR) factor, linked by a low-grade systemic inflammation mediated by C-reactive protein (CRP). Patients with periodontitis reported higher serum CRP...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394419/ https://www.ncbi.nlm.nih.gov/pubmed/34439905 http://dx.doi.org/10.3390/biom11081238 |
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author | Da Venezia, Claudia Hussein, Nayib Hernández, Marcela Contreras, Johanna Morales, Alicia Valdés, Macarena Rojas, Francisca Matamala, Loreto Hernández-Ríos, Patricia |
author_facet | Da Venezia, Claudia Hussein, Nayib Hernández, Marcela Contreras, Johanna Morales, Alicia Valdés, Macarena Rojas, Francisca Matamala, Loreto Hernández-Ríos, Patricia |
author_sort | Da Venezia, Claudia |
collection | PubMed |
description | Cardiovascular diseases (CVD) are highly prevalent non-communicable diseases worldwide. Periodontitis may act as a non-traditional cardiovascular risk (CVR) factor, linked by a low-grade systemic inflammation mediated by C-reactive protein (CRP). Patients with periodontitis reported higher serum CRP levels; however, a CRP systemic and periodontal correlation in gingival crevicular fluid (GCF) and its CVR impact have been barely studied. We aimed to assess the association between periodontal diseases and CVR in a group of adult women, based on serum high-sensitivity CRP (hs-CRP) levels; and secondly, to determine the association between serum and GCF CRP levels. Gingival crevicular fluid and blood samples were obtained from women with periodontitis, gingivitis, and healthy controls. Serum and GCF CRP were determined by turbidimetric method and Luminex technology, respectively. Data were analyzed and adjusted by CVR factors. All women presented moderate CVR, without an evident association between serum hs-CRP levels and periodontal diseases. While serum hs-CRP concentrations did not significantly differ between groups, patients with gingivitis and periodontitis showed higher CRP levels in GCF, which positively correlated to CRP detection in serum. |
format | Online Article Text |
id | pubmed-8394419 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83944192021-08-28 Assessment of Cardiovascular Risk in Women with Periodontal Diseases According to C-reactive Protein Levels Da Venezia, Claudia Hussein, Nayib Hernández, Marcela Contreras, Johanna Morales, Alicia Valdés, Macarena Rojas, Francisca Matamala, Loreto Hernández-Ríos, Patricia Biomolecules Article Cardiovascular diseases (CVD) are highly prevalent non-communicable diseases worldwide. Periodontitis may act as a non-traditional cardiovascular risk (CVR) factor, linked by a low-grade systemic inflammation mediated by C-reactive protein (CRP). Patients with periodontitis reported higher serum CRP levels; however, a CRP systemic and periodontal correlation in gingival crevicular fluid (GCF) and its CVR impact have been barely studied. We aimed to assess the association between periodontal diseases and CVR in a group of adult women, based on serum high-sensitivity CRP (hs-CRP) levels; and secondly, to determine the association between serum and GCF CRP levels. Gingival crevicular fluid and blood samples were obtained from women with periodontitis, gingivitis, and healthy controls. Serum and GCF CRP were determined by turbidimetric method and Luminex technology, respectively. Data were analyzed and adjusted by CVR factors. All women presented moderate CVR, without an evident association between serum hs-CRP levels and periodontal diseases. While serum hs-CRP concentrations did not significantly differ between groups, patients with gingivitis and periodontitis showed higher CRP levels in GCF, which positively correlated to CRP detection in serum. MDPI 2021-08-19 /pmc/articles/PMC8394419/ /pubmed/34439905 http://dx.doi.org/10.3390/biom11081238 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Da Venezia, Claudia Hussein, Nayib Hernández, Marcela Contreras, Johanna Morales, Alicia Valdés, Macarena Rojas, Francisca Matamala, Loreto Hernández-Ríos, Patricia Assessment of Cardiovascular Risk in Women with Periodontal Diseases According to C-reactive Protein Levels |
title | Assessment of Cardiovascular Risk in Women with Periodontal Diseases According to C-reactive Protein Levels |
title_full | Assessment of Cardiovascular Risk in Women with Periodontal Diseases According to C-reactive Protein Levels |
title_fullStr | Assessment of Cardiovascular Risk in Women with Periodontal Diseases According to C-reactive Protein Levels |
title_full_unstemmed | Assessment of Cardiovascular Risk in Women with Periodontal Diseases According to C-reactive Protein Levels |
title_short | Assessment of Cardiovascular Risk in Women with Periodontal Diseases According to C-reactive Protein Levels |
title_sort | assessment of cardiovascular risk in women with periodontal diseases according to c-reactive protein levels |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394419/ https://www.ncbi.nlm.nih.gov/pubmed/34439905 http://dx.doi.org/10.3390/biom11081238 |
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