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Probiotics and Prebiotics as a Strategy for Non-Alcoholic Fatty Liver Disease, a Narrative Review

Non-alcoholic fatty liver disease (NAFLD) is a chronic non-communicable disease, with a prevalence of 25% worldwide. This pathology is a multifactorial illness, and is associated with different risks factors, including hypertension, hyperglycemia, dyslipidemia, and obesity. Beside these predisposing...

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Autores principales: Castillo, Valentina, Figueroa, Fernanda, González-Pizarro, Karoll, Jopia, Paz, Ibacache-Quiroga, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394424/
https://www.ncbi.nlm.nih.gov/pubmed/34441497
http://dx.doi.org/10.3390/foods10081719
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author Castillo, Valentina
Figueroa, Fernanda
González-Pizarro, Karoll
Jopia, Paz
Ibacache-Quiroga, Claudia
author_facet Castillo, Valentina
Figueroa, Fernanda
González-Pizarro, Karoll
Jopia, Paz
Ibacache-Quiroga, Claudia
author_sort Castillo, Valentina
collection PubMed
description Non-alcoholic fatty liver disease (NAFLD) is a chronic non-communicable disease, with a prevalence of 25% worldwide. This pathology is a multifactorial illness, and is associated with different risks factors, including hypertension, hyperglycemia, dyslipidemia, and obesity. Beside these predisposing features, NAFLD has been related to changes in the microbiota, which favor the disease progression. In this context, the modulation of the gut microbiota has emerged as a new therapeutic target for the prophylaxis and treatment of NAFLD. This review describes the changes in the gut microbiota associated with NAFLD and the effect of probiotics, prebiotics, and synbiotics on the gut microbiota, liver damage, anthropometric parameters, blood lipids, inflammation markers and insulin resistance in these patients.
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spelling pubmed-83944242021-08-28 Probiotics and Prebiotics as a Strategy for Non-Alcoholic Fatty Liver Disease, a Narrative Review Castillo, Valentina Figueroa, Fernanda González-Pizarro, Karoll Jopia, Paz Ibacache-Quiroga, Claudia Foods Review Non-alcoholic fatty liver disease (NAFLD) is a chronic non-communicable disease, with a prevalence of 25% worldwide. This pathology is a multifactorial illness, and is associated with different risks factors, including hypertension, hyperglycemia, dyslipidemia, and obesity. Beside these predisposing features, NAFLD has been related to changes in the microbiota, which favor the disease progression. In this context, the modulation of the gut microbiota has emerged as a new therapeutic target for the prophylaxis and treatment of NAFLD. This review describes the changes in the gut microbiota associated with NAFLD and the effect of probiotics, prebiotics, and synbiotics on the gut microbiota, liver damage, anthropometric parameters, blood lipids, inflammation markers and insulin resistance in these patients. MDPI 2021-07-25 /pmc/articles/PMC8394424/ /pubmed/34441497 http://dx.doi.org/10.3390/foods10081719 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Castillo, Valentina
Figueroa, Fernanda
González-Pizarro, Karoll
Jopia, Paz
Ibacache-Quiroga, Claudia
Probiotics and Prebiotics as a Strategy for Non-Alcoholic Fatty Liver Disease, a Narrative Review
title Probiotics and Prebiotics as a Strategy for Non-Alcoholic Fatty Liver Disease, a Narrative Review
title_full Probiotics and Prebiotics as a Strategy for Non-Alcoholic Fatty Liver Disease, a Narrative Review
title_fullStr Probiotics and Prebiotics as a Strategy for Non-Alcoholic Fatty Liver Disease, a Narrative Review
title_full_unstemmed Probiotics and Prebiotics as a Strategy for Non-Alcoholic Fatty Liver Disease, a Narrative Review
title_short Probiotics and Prebiotics as a Strategy for Non-Alcoholic Fatty Liver Disease, a Narrative Review
title_sort probiotics and prebiotics as a strategy for non-alcoholic fatty liver disease, a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394424/
https://www.ncbi.nlm.nih.gov/pubmed/34441497
http://dx.doi.org/10.3390/foods10081719
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