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Critical Roles of Calpastatin in Ischemia/Reperfusion Injury in Aged Livers

Ischemia/reperfusion (I/R) injury unavoidably occurs during hepatic resection and transplantation. Aged livers poorly tolerate I/R during surgical treatment. Although livers have a powerful endogenous inhibitor of calpains, calpastatin (CAST), I/R activates calpains, leading to impaired autophagy, m...

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Detalles Bibliográficos
Autores principales:	Flores-Toro, Joseph, Chun, Sung-Kook, Shin, Jun-Kyu, Campbell, Joan, Lichtenberger, Melissa, Chapman, William, Zendejas, Ivan, Behrns, Kevin, Leeuwenburgh, Christiaan, Kim, Jae-Sung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394464/ https://www.ncbi.nlm.nih.gov/pubmed/34440632 http://dx.doi.org/10.3390/cells10081863

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