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Diagnosis and Management of Mixed Transcortical Aphasia Due to Multiple Predisposing Factors, including Postpartum and Severe Inherited Thrombophilia, Affecting Multiple Cerebral Venous and Dural Sinus Thrombosis: Case Report and Literature Review

Cerebral venous and dural sinus thrombosis (CVT) is an uncommon disease in the general population, although it is a significant stroke type throughout pregnancy and the puerperium. Studies describing this subtype of CVT are limited. Most pregnancy-associated CVT happen in late pregnancy, or more com...

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Autores principales: Jianu, Dragoș Cătălin, Jianu, Silviana Nina, Dan, Traian Flavius, Iacob, Nicoleta, Munteanu, Georgiana, Motoc, Andrei Gheorghe Marius, Băloi, Adelina, Hodorogea, Daniela, Axelerad, Any Docu, Pleș, Horia, Petrica, Ligia, Gogu, Anca Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394489/
https://www.ncbi.nlm.nih.gov/pubmed/34441359
http://dx.doi.org/10.3390/diagnostics11081425
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author Jianu, Dragoș Cătălin
Jianu, Silviana Nina
Dan, Traian Flavius
Iacob, Nicoleta
Munteanu, Georgiana
Motoc, Andrei Gheorghe Marius
Băloi, Adelina
Hodorogea, Daniela
Axelerad, Any Docu
Pleș, Horia
Petrica, Ligia
Gogu, Anca Elena
author_facet Jianu, Dragoș Cătălin
Jianu, Silviana Nina
Dan, Traian Flavius
Iacob, Nicoleta
Munteanu, Georgiana
Motoc, Andrei Gheorghe Marius
Băloi, Adelina
Hodorogea, Daniela
Axelerad, Any Docu
Pleș, Horia
Petrica, Ligia
Gogu, Anca Elena
author_sort Jianu, Dragoș Cătălin
collection PubMed
description Cerebral venous and dural sinus thrombosis (CVT) is an uncommon disease in the general population, although it is a significant stroke type throughout pregnancy and the puerperium. Studies describing this subtype of CVT are limited. Most pregnancy-associated CVT happen in late pregnancy, or more commonly in the first postpartum weeks, being associated with venous thrombosis outside the nervous system. Case presentation: The current study describes a case of multiple CVT in a 38-year-old woman with multiple risk factors (including severe inherited thrombophilia and being in the puerperium period), presenting mixed transcortical aphasia (a rare type of aphasia) associated with right moderate hemiparesis and intracranial hypertension. The clinical diagnosis of CVT was confirmed by laboratory data and neuroimaging data from head computed tomography, magnetic resonance imaging, and magnetic resonance venography. She was successfully treated with low-molecular-weight heparin (anticoagulation) and osmotic diuretics (mannitol) for increased intracranial pressure and cerebral edema. At discharge, after 15 days of evolution, she presented a partial recovery, with anomic plus aphasia and mild right hemiparesis. Clinical and imaging follow-up was performed at 6 months after discharge; our patient presented normal language and mild right central facial paresis, with chronic left thalamic, caudate nucleus, and internal capsule infarcts and a partial recanalization of the dural sinuses.
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spelling pubmed-83944892021-08-28 Diagnosis and Management of Mixed Transcortical Aphasia Due to Multiple Predisposing Factors, including Postpartum and Severe Inherited Thrombophilia, Affecting Multiple Cerebral Venous and Dural Sinus Thrombosis: Case Report and Literature Review Jianu, Dragoș Cătălin Jianu, Silviana Nina Dan, Traian Flavius Iacob, Nicoleta Munteanu, Georgiana Motoc, Andrei Gheorghe Marius Băloi, Adelina Hodorogea, Daniela Axelerad, Any Docu Pleș, Horia Petrica, Ligia Gogu, Anca Elena Diagnostics (Basel) Case Report Cerebral venous and dural sinus thrombosis (CVT) is an uncommon disease in the general population, although it is a significant stroke type throughout pregnancy and the puerperium. Studies describing this subtype of CVT are limited. Most pregnancy-associated CVT happen in late pregnancy, or more commonly in the first postpartum weeks, being associated with venous thrombosis outside the nervous system. Case presentation: The current study describes a case of multiple CVT in a 38-year-old woman with multiple risk factors (including severe inherited thrombophilia and being in the puerperium period), presenting mixed transcortical aphasia (a rare type of aphasia) associated with right moderate hemiparesis and intracranial hypertension. The clinical diagnosis of CVT was confirmed by laboratory data and neuroimaging data from head computed tomography, magnetic resonance imaging, and magnetic resonance venography. She was successfully treated with low-molecular-weight heparin (anticoagulation) and osmotic diuretics (mannitol) for increased intracranial pressure and cerebral edema. At discharge, after 15 days of evolution, she presented a partial recovery, with anomic plus aphasia and mild right hemiparesis. Clinical and imaging follow-up was performed at 6 months after discharge; our patient presented normal language and mild right central facial paresis, with chronic left thalamic, caudate nucleus, and internal capsule infarcts and a partial recanalization of the dural sinuses. MDPI 2021-08-06 /pmc/articles/PMC8394489/ /pubmed/34441359 http://dx.doi.org/10.3390/diagnostics11081425 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Jianu, Dragoș Cătălin
Jianu, Silviana Nina
Dan, Traian Flavius
Iacob, Nicoleta
Munteanu, Georgiana
Motoc, Andrei Gheorghe Marius
Băloi, Adelina
Hodorogea, Daniela
Axelerad, Any Docu
Pleș, Horia
Petrica, Ligia
Gogu, Anca Elena
Diagnosis and Management of Mixed Transcortical Aphasia Due to Multiple Predisposing Factors, including Postpartum and Severe Inherited Thrombophilia, Affecting Multiple Cerebral Venous and Dural Sinus Thrombosis: Case Report and Literature Review
title Diagnosis and Management of Mixed Transcortical Aphasia Due to Multiple Predisposing Factors, including Postpartum and Severe Inherited Thrombophilia, Affecting Multiple Cerebral Venous and Dural Sinus Thrombosis: Case Report and Literature Review
title_full Diagnosis and Management of Mixed Transcortical Aphasia Due to Multiple Predisposing Factors, including Postpartum and Severe Inherited Thrombophilia, Affecting Multiple Cerebral Venous and Dural Sinus Thrombosis: Case Report and Literature Review
title_fullStr Diagnosis and Management of Mixed Transcortical Aphasia Due to Multiple Predisposing Factors, including Postpartum and Severe Inherited Thrombophilia, Affecting Multiple Cerebral Venous and Dural Sinus Thrombosis: Case Report and Literature Review
title_full_unstemmed Diagnosis and Management of Mixed Transcortical Aphasia Due to Multiple Predisposing Factors, including Postpartum and Severe Inherited Thrombophilia, Affecting Multiple Cerebral Venous and Dural Sinus Thrombosis: Case Report and Literature Review
title_short Diagnosis and Management of Mixed Transcortical Aphasia Due to Multiple Predisposing Factors, including Postpartum and Severe Inherited Thrombophilia, Affecting Multiple Cerebral Venous and Dural Sinus Thrombosis: Case Report and Literature Review
title_sort diagnosis and management of mixed transcortical aphasia due to multiple predisposing factors, including postpartum and severe inherited thrombophilia, affecting multiple cerebral venous and dural sinus thrombosis: case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394489/
https://www.ncbi.nlm.nih.gov/pubmed/34441359
http://dx.doi.org/10.3390/diagnostics11081425
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