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Alterations of gut microbiota in gestational diabetes patients during the second trimester of pregnancy in the Shanghai Han population

BACKGROUND: The causes of gestational diabetes mellitus (GDM) are still unclear. Recent studies have found that the imbalance of the gut microbiome could lead to disorders of human metabolism and immune system, resulting in GDM. This study aims to reveal the different gut compositions between GDM an...

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Autores principales: Su, Yao, Wang, Hong-Kun, Gan, Xu-Pei, Chen, Li, Cao, Yan-Nan, Cheng, De-Cui, Zhang, Dong-Yao, Liu, Wen-Yu, Li, Fei-Fei, Xu, Xian-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394568/
https://www.ncbi.nlm.nih.gov/pubmed/34446048
http://dx.doi.org/10.1186/s12967-021-03040-9
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author Su, Yao
Wang, Hong-Kun
Gan, Xu-Pei
Chen, Li
Cao, Yan-Nan
Cheng, De-Cui
Zhang, Dong-Yao
Liu, Wen-Yu
Li, Fei-Fei
Xu, Xian-Ming
author_facet Su, Yao
Wang, Hong-Kun
Gan, Xu-Pei
Chen, Li
Cao, Yan-Nan
Cheng, De-Cui
Zhang, Dong-Yao
Liu, Wen-Yu
Li, Fei-Fei
Xu, Xian-Ming
author_sort Su, Yao
collection PubMed
description BACKGROUND: The causes of gestational diabetes mellitus (GDM) are still unclear. Recent studies have found that the imbalance of the gut microbiome could lead to disorders of human metabolism and immune system, resulting in GDM. This study aims to reveal the different gut compositions between GDM and normoglycemic pregnant women and find the relationship between gut microbiota and GDM. METHODS: Fecal microbiota profiles from women with GDM (n = 21) and normoglycemic women (n = 32) were assessed by 16S rRNA gene sequencing. Fasting metabolic hormone concentrations were measured using multiplex ELISA. RESULTS: Metabolic hormone levels, microbiome profiles, and inferred functional characteristics differed between women with GDM and healthy women. Additionally, four phyla and seven genera levels have different correlations with plasma glucose and insulin levels. Corynebacteriales (order), Nocardiaceae (family), Desulfovibrionaceae (family), Rhodococcus (genus), and Bacteroidetes (phylum) may be the taxonomic biomarkers of GDM. Microbial gene functions related to amino sugar and nucleotide sugar metabolism were found to be enriched in patients with GDM. CONCLUSION: Our study indicated that dysbiosis of the gut microbiome exists in patients with GDM in the second trimester of pregnancy, and gut microbiota might be a potential diagnostic biomarker for the diagnosis, prevention, and treatment of GDM. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12967-021-03040-9.
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spelling pubmed-83945682021-08-30 Alterations of gut microbiota in gestational diabetes patients during the second trimester of pregnancy in the Shanghai Han population Su, Yao Wang, Hong-Kun Gan, Xu-Pei Chen, Li Cao, Yan-Nan Cheng, De-Cui Zhang, Dong-Yao Liu, Wen-Yu Li, Fei-Fei Xu, Xian-Ming J Transl Med Research BACKGROUND: The causes of gestational diabetes mellitus (GDM) are still unclear. Recent studies have found that the imbalance of the gut microbiome could lead to disorders of human metabolism and immune system, resulting in GDM. This study aims to reveal the different gut compositions between GDM and normoglycemic pregnant women and find the relationship between gut microbiota and GDM. METHODS: Fecal microbiota profiles from women with GDM (n = 21) and normoglycemic women (n = 32) were assessed by 16S rRNA gene sequencing. Fasting metabolic hormone concentrations were measured using multiplex ELISA. RESULTS: Metabolic hormone levels, microbiome profiles, and inferred functional characteristics differed between women with GDM and healthy women. Additionally, four phyla and seven genera levels have different correlations with plasma glucose and insulin levels. Corynebacteriales (order), Nocardiaceae (family), Desulfovibrionaceae (family), Rhodococcus (genus), and Bacteroidetes (phylum) may be the taxonomic biomarkers of GDM. Microbial gene functions related to amino sugar and nucleotide sugar metabolism were found to be enriched in patients with GDM. CONCLUSION: Our study indicated that dysbiosis of the gut microbiome exists in patients with GDM in the second trimester of pregnancy, and gut microbiota might be a potential diagnostic biomarker for the diagnosis, prevention, and treatment of GDM. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12967-021-03040-9. BioMed Central 2021-08-26 /pmc/articles/PMC8394568/ /pubmed/34446048 http://dx.doi.org/10.1186/s12967-021-03040-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Su, Yao
Wang, Hong-Kun
Gan, Xu-Pei
Chen, Li
Cao, Yan-Nan
Cheng, De-Cui
Zhang, Dong-Yao
Liu, Wen-Yu
Li, Fei-Fei
Xu, Xian-Ming
Alterations of gut microbiota in gestational diabetes patients during the second trimester of pregnancy in the Shanghai Han population
title Alterations of gut microbiota in gestational diabetes patients during the second trimester of pregnancy in the Shanghai Han population
title_full Alterations of gut microbiota in gestational diabetes patients during the second trimester of pregnancy in the Shanghai Han population
title_fullStr Alterations of gut microbiota in gestational diabetes patients during the second trimester of pregnancy in the Shanghai Han population
title_full_unstemmed Alterations of gut microbiota in gestational diabetes patients during the second trimester of pregnancy in the Shanghai Han population
title_short Alterations of gut microbiota in gestational diabetes patients during the second trimester of pregnancy in the Shanghai Han population
title_sort alterations of gut microbiota in gestational diabetes patients during the second trimester of pregnancy in the shanghai han population
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394568/
https://www.ncbi.nlm.nih.gov/pubmed/34446048
http://dx.doi.org/10.1186/s12967-021-03040-9
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