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Sustained Axonal Degeneration in Prolonged Disorders of Consciousness
(1) Background: Sustained axonal degeneration may play a critical role in prolonged disorder of consciousness (DOCs) pathophysiology. We evaluated levels of neurofilament light chain (NFL), an axonal injury marker, in patients with unresponsive wakefulness syndrome (UWS) and in the minimally conscio...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394581/ https://www.ncbi.nlm.nih.gov/pubmed/34439687 http://dx.doi.org/10.3390/brainsci11081068 |
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author | Bagnato, Sergio D’Ippolito, Maria Enza Boccagni, Cristina De Tanti, Antonio Lucca, Lucia Francesca Nardone, Antonio Salucci, Pamela Fiorilla, Teresa Pingue, Valeria Gennaro, Serena Ursino, Maria Colombo, Valentina Barone, Teresa Rubino, Francesca Andriolo, Maria |
author_facet | Bagnato, Sergio D’Ippolito, Maria Enza Boccagni, Cristina De Tanti, Antonio Lucca, Lucia Francesca Nardone, Antonio Salucci, Pamela Fiorilla, Teresa Pingue, Valeria Gennaro, Serena Ursino, Maria Colombo, Valentina Barone, Teresa Rubino, Francesca Andriolo, Maria |
author_sort | Bagnato, Sergio |
collection | PubMed |
description | (1) Background: Sustained axonal degeneration may play a critical role in prolonged disorder of consciousness (DOCs) pathophysiology. We evaluated levels of neurofilament light chain (NFL), an axonal injury marker, in patients with unresponsive wakefulness syndrome (UWS) and in the minimally conscious state (MCS) after traumatic brain injury (TBI) and hypoxic-ischemic brain injury (HIBI). (2) Methods: This prospective multicenter blinded study involved 70 patients with prolonged DOC and 70 sex-/age-matched healthy controls. Serum NFL levels were evaluated at 1–3 and 6 months post-injury and compared with those of controls. NFL levels were compared by DOC severity (UWS vs. MCS) and etiology (TBI vs. HIBI). (3) Results: Patients’ serum NFL levels were significantly higher than those of controls at 1–3 and 6 months post-injury (medians, 1729 and 426 vs. 90 pg/mL; both p < 0.0001). NFL levels were higher in patients with UWS than in those in MCS at 1–3 months post-injury (p = 0.008) and in patients with HIBI than in those with TBI at 6 months post-injury (p = 0.037). (4) Conclusions: Patients with prolonged DOC present sustained axonal degeneration that is affected differently over time by brain injury severity and etiology. |
format | Online Article Text |
id | pubmed-8394581 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83945812021-08-28 Sustained Axonal Degeneration in Prolonged Disorders of Consciousness Bagnato, Sergio D’Ippolito, Maria Enza Boccagni, Cristina De Tanti, Antonio Lucca, Lucia Francesca Nardone, Antonio Salucci, Pamela Fiorilla, Teresa Pingue, Valeria Gennaro, Serena Ursino, Maria Colombo, Valentina Barone, Teresa Rubino, Francesca Andriolo, Maria Brain Sci Article (1) Background: Sustained axonal degeneration may play a critical role in prolonged disorder of consciousness (DOCs) pathophysiology. We evaluated levels of neurofilament light chain (NFL), an axonal injury marker, in patients with unresponsive wakefulness syndrome (UWS) and in the minimally conscious state (MCS) after traumatic brain injury (TBI) and hypoxic-ischemic brain injury (HIBI). (2) Methods: This prospective multicenter blinded study involved 70 patients with prolonged DOC and 70 sex-/age-matched healthy controls. Serum NFL levels were evaluated at 1–3 and 6 months post-injury and compared with those of controls. NFL levels were compared by DOC severity (UWS vs. MCS) and etiology (TBI vs. HIBI). (3) Results: Patients’ serum NFL levels were significantly higher than those of controls at 1–3 and 6 months post-injury (medians, 1729 and 426 vs. 90 pg/mL; both p < 0.0001). NFL levels were higher in patients with UWS than in those in MCS at 1–3 months post-injury (p = 0.008) and in patients with HIBI than in those with TBI at 6 months post-injury (p = 0.037). (4) Conclusions: Patients with prolonged DOC present sustained axonal degeneration that is affected differently over time by brain injury severity and etiology. MDPI 2021-08-14 /pmc/articles/PMC8394581/ /pubmed/34439687 http://dx.doi.org/10.3390/brainsci11081068 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bagnato, Sergio D’Ippolito, Maria Enza Boccagni, Cristina De Tanti, Antonio Lucca, Lucia Francesca Nardone, Antonio Salucci, Pamela Fiorilla, Teresa Pingue, Valeria Gennaro, Serena Ursino, Maria Colombo, Valentina Barone, Teresa Rubino, Francesca Andriolo, Maria Sustained Axonal Degeneration in Prolonged Disorders of Consciousness |
title | Sustained Axonal Degeneration in Prolonged Disorders of Consciousness |
title_full | Sustained Axonal Degeneration in Prolonged Disorders of Consciousness |
title_fullStr | Sustained Axonal Degeneration in Prolonged Disorders of Consciousness |
title_full_unstemmed | Sustained Axonal Degeneration in Prolonged Disorders of Consciousness |
title_short | Sustained Axonal Degeneration in Prolonged Disorders of Consciousness |
title_sort | sustained axonal degeneration in prolonged disorders of consciousness |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394581/ https://www.ncbi.nlm.nih.gov/pubmed/34439687 http://dx.doi.org/10.3390/brainsci11081068 |
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