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Sustained Axonal Degeneration in Prolonged Disorders of Consciousness

(1) Background: Sustained axonal degeneration may play a critical role in prolonged disorder of consciousness (DOCs) pathophysiology. We evaluated levels of neurofilament light chain (NFL), an axonal injury marker, in patients with unresponsive wakefulness syndrome (UWS) and in the minimally conscio...

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Autores principales: Bagnato, Sergio, D’Ippolito, Maria Enza, Boccagni, Cristina, De Tanti, Antonio, Lucca, Lucia Francesca, Nardone, Antonio, Salucci, Pamela, Fiorilla, Teresa, Pingue, Valeria, Gennaro, Serena, Ursino, Maria, Colombo, Valentina, Barone, Teresa, Rubino, Francesca, Andriolo, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394581/
https://www.ncbi.nlm.nih.gov/pubmed/34439687
http://dx.doi.org/10.3390/brainsci11081068
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author Bagnato, Sergio
D’Ippolito, Maria Enza
Boccagni, Cristina
De Tanti, Antonio
Lucca, Lucia Francesca
Nardone, Antonio
Salucci, Pamela
Fiorilla, Teresa
Pingue, Valeria
Gennaro, Serena
Ursino, Maria
Colombo, Valentina
Barone, Teresa
Rubino, Francesca
Andriolo, Maria
author_facet Bagnato, Sergio
D’Ippolito, Maria Enza
Boccagni, Cristina
De Tanti, Antonio
Lucca, Lucia Francesca
Nardone, Antonio
Salucci, Pamela
Fiorilla, Teresa
Pingue, Valeria
Gennaro, Serena
Ursino, Maria
Colombo, Valentina
Barone, Teresa
Rubino, Francesca
Andriolo, Maria
author_sort Bagnato, Sergio
collection PubMed
description (1) Background: Sustained axonal degeneration may play a critical role in prolonged disorder of consciousness (DOCs) pathophysiology. We evaluated levels of neurofilament light chain (NFL), an axonal injury marker, in patients with unresponsive wakefulness syndrome (UWS) and in the minimally conscious state (MCS) after traumatic brain injury (TBI) and hypoxic-ischemic brain injury (HIBI). (2) Methods: This prospective multicenter blinded study involved 70 patients with prolonged DOC and 70 sex-/age-matched healthy controls. Serum NFL levels were evaluated at 1–3 and 6 months post-injury and compared with those of controls. NFL levels were compared by DOC severity (UWS vs. MCS) and etiology (TBI vs. HIBI). (3) Results: Patients’ serum NFL levels were significantly higher than those of controls at 1–3 and 6 months post-injury (medians, 1729 and 426 vs. 90 pg/mL; both p < 0.0001). NFL levels were higher in patients with UWS than in those in MCS at 1–3 months post-injury (p = 0.008) and in patients with HIBI than in those with TBI at 6 months post-injury (p = 0.037). (4) Conclusions: Patients with prolonged DOC present sustained axonal degeneration that is affected differently over time by brain injury severity and etiology.
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spelling pubmed-83945812021-08-28 Sustained Axonal Degeneration in Prolonged Disorders of Consciousness Bagnato, Sergio D’Ippolito, Maria Enza Boccagni, Cristina De Tanti, Antonio Lucca, Lucia Francesca Nardone, Antonio Salucci, Pamela Fiorilla, Teresa Pingue, Valeria Gennaro, Serena Ursino, Maria Colombo, Valentina Barone, Teresa Rubino, Francesca Andriolo, Maria Brain Sci Article (1) Background: Sustained axonal degeneration may play a critical role in prolonged disorder of consciousness (DOCs) pathophysiology. We evaluated levels of neurofilament light chain (NFL), an axonal injury marker, in patients with unresponsive wakefulness syndrome (UWS) and in the minimally conscious state (MCS) after traumatic brain injury (TBI) and hypoxic-ischemic brain injury (HIBI). (2) Methods: This prospective multicenter blinded study involved 70 patients with prolonged DOC and 70 sex-/age-matched healthy controls. Serum NFL levels were evaluated at 1–3 and 6 months post-injury and compared with those of controls. NFL levels were compared by DOC severity (UWS vs. MCS) and etiology (TBI vs. HIBI). (3) Results: Patients’ serum NFL levels were significantly higher than those of controls at 1–3 and 6 months post-injury (medians, 1729 and 426 vs. 90 pg/mL; both p < 0.0001). NFL levels were higher in patients with UWS than in those in MCS at 1–3 months post-injury (p = 0.008) and in patients with HIBI than in those with TBI at 6 months post-injury (p = 0.037). (4) Conclusions: Patients with prolonged DOC present sustained axonal degeneration that is affected differently over time by brain injury severity and etiology. MDPI 2021-08-14 /pmc/articles/PMC8394581/ /pubmed/34439687 http://dx.doi.org/10.3390/brainsci11081068 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bagnato, Sergio
D’Ippolito, Maria Enza
Boccagni, Cristina
De Tanti, Antonio
Lucca, Lucia Francesca
Nardone, Antonio
Salucci, Pamela
Fiorilla, Teresa
Pingue, Valeria
Gennaro, Serena
Ursino, Maria
Colombo, Valentina
Barone, Teresa
Rubino, Francesca
Andriolo, Maria
Sustained Axonal Degeneration in Prolonged Disorders of Consciousness
title Sustained Axonal Degeneration in Prolonged Disorders of Consciousness
title_full Sustained Axonal Degeneration in Prolonged Disorders of Consciousness
title_fullStr Sustained Axonal Degeneration in Prolonged Disorders of Consciousness
title_full_unstemmed Sustained Axonal Degeneration in Prolonged Disorders of Consciousness
title_short Sustained Axonal Degeneration in Prolonged Disorders of Consciousness
title_sort sustained axonal degeneration in prolonged disorders of consciousness
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394581/
https://www.ncbi.nlm.nih.gov/pubmed/34439687
http://dx.doi.org/10.3390/brainsci11081068
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