The role of the odorant receptors in the formation of the sensory map

In the olfactory system, odorant receptors (ORs) expressed at the cell membrane of olfactory sensory neurons detect odorants and direct sensory axons toward precise target locations in the brain, reflected in the presence of olfactory sensory maps. This dual role of ORs is corroborated by their subc...

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Detalles Bibliográficos
Autores principales: Francia, Simona, Lodovichi, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394594/
https://www.ncbi.nlm.nih.gov/pubmed/34452614
http://dx.doi.org/10.1186/s12915-021-01116-y
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author Francia, Simona
Lodovichi, Claudia
author_facet Francia, Simona
Lodovichi, Claudia
author_sort Francia, Simona
collection PubMed
description In the olfactory system, odorant receptors (ORs) expressed at the cell membrane of olfactory sensory neurons detect odorants and direct sensory axons toward precise target locations in the brain, reflected in the presence of olfactory sensory maps. This dual role of ORs is corroborated by their subcellular expression both in cilia, where they bind odorants, and at axon terminals, a location suitable for axon guidance cues. Here, we provide an overview and discuss previous work on the role of ORs in establishing the topographic organization of the olfactory system and recent findings on the mechanisms of activation and function of axonal ORs.
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spelling pubmed-83945942021-08-30 The role of the odorant receptors in the formation of the sensory map Francia, Simona Lodovichi, Claudia BMC Biol Review In the olfactory system, odorant receptors (ORs) expressed at the cell membrane of olfactory sensory neurons detect odorants and direct sensory axons toward precise target locations in the brain, reflected in the presence of olfactory sensory maps. This dual role of ORs is corroborated by their subcellular expression both in cilia, where they bind odorants, and at axon terminals, a location suitable for axon guidance cues. Here, we provide an overview and discuss previous work on the role of ORs in establishing the topographic organization of the olfactory system and recent findings on the mechanisms of activation and function of axonal ORs. BioMed Central 2021-08-27 /pmc/articles/PMC8394594/ /pubmed/34452614 http://dx.doi.org/10.1186/s12915-021-01116-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Francia, Simona
Lodovichi, Claudia
The role of the odorant receptors in the formation of the sensory map
title The role of the odorant receptors in the formation of the sensory map
title_full The role of the odorant receptors in the formation of the sensory map
title_fullStr The role of the odorant receptors in the formation of the sensory map
title_full_unstemmed The role of the odorant receptors in the formation of the sensory map
title_short The role of the odorant receptors in the formation of the sensory map
title_sort role of the odorant receptors in the formation of the sensory map
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394594/
https://www.ncbi.nlm.nih.gov/pubmed/34452614
http://dx.doi.org/10.1186/s12915-021-01116-y
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