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DNA methyltransferase inhibitors combination therapy for the treatment of solid tumor: mechanism and clinical application

DNA methylation, an epigenetic modification, regulates gene transcription and maintains genome stability. DNA methyltransferase (DNMT) inhibitors can activate silenced genes at low doses and cause cytotoxicity at high doses. The ability of DNMT inhibitors to reverse epimutations is the basis of thei...

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Detalles Bibliográficos
Autores principales:	Hu, Chunhong, Liu, Xiaohan, Zeng, Yue, Liu, Junqi, Wu, Fang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394595/ https://www.ncbi.nlm.nih.gov/pubmed/34452630 http://dx.doi.org/10.1186/s13148-021-01154-x

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