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A Comparison of Lung Ultrasound and Computed Tomography in the Diagnosis of Patients with COVID-19: A Systematic Review and Meta-Analysis

Background Lung ultrasound (LUS) and computed tomography (CT) can both be used for diagnosis of interstitial pneumonia caused by coronavirus disease 2019 (COVID-19), but the agreement between LUS and CT is unknown. Purpose to compare the agreement of LUS and CT in the diagnosis of interstitial pneum...

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Autores principales: Wang, Mengshu, Luo, Xufei, Wang, Ling, Estill, Janne, Lv, Meng, Zhu, Ying, Wang, Qi, Xiao, Xiaojuan, Song, Yang, Lee, Myeong Soo, Ahn, Hyeong Sik, Lei, Junqiang, Tian, Jinhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394642/
https://www.ncbi.nlm.nih.gov/pubmed/34441286
http://dx.doi.org/10.3390/diagnostics11081351
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author Wang, Mengshu
Luo, Xufei
Wang, Ling
Estill, Janne
Lv, Meng
Zhu, Ying
Wang, Qi
Xiao, Xiaojuan
Song, Yang
Lee, Myeong Soo
Ahn, Hyeong Sik
Lei, Junqiang
Tian, Jinhui
author_facet Wang, Mengshu
Luo, Xufei
Wang, Ling
Estill, Janne
Lv, Meng
Zhu, Ying
Wang, Qi
Xiao, Xiaojuan
Song, Yang
Lee, Myeong Soo
Ahn, Hyeong Sik
Lei, Junqiang
Tian, Jinhui
author_sort Wang, Mengshu
collection PubMed
description Background Lung ultrasound (LUS) and computed tomography (CT) can both be used for diagnosis of interstitial pneumonia caused by coronavirus disease 2019 (COVID-19), but the agreement between LUS and CT is unknown. Purpose to compare the agreement of LUS and CT in the diagnosis of interstitial pneumonia caused by COVID-19. Materials and Methods We searched PubMed, Cochrane library, Embase, Chinese Biomedicine Literature, and WHO COVID-19 databases to identify studies that compared LUS with CT in the diagnosis of interstitial pneumonia caused by COVID-19. We calculated the pooled overall, positive and negative percent agreements, diagnostic odds ratio (DOR) and the area under the standard receiver operating curve (SROC) for LUS in the diagnosis of COVID-19 compared with CT. Results We identified 1896 records, of which nine studies involving 531 patients were finally included. The pooled overall, positive and negative percentage agreements of LUS for the diagnosis of interstitial pneumonia caused by COVID-19 compared with CT were 81% (95% confidence interval [CI] 43–99%), 96% (95% CI, 80–99%, I(2) = 92.15%) and 80% (95%CI, 60–92%, I(2) = 92.85%), respectively. DOR was 37.41 (95% CI, 9.43–148.49, I(2) = 63.9%), and the area under the SROC curve was 0.94 (95% CI, 0.92–0.96). The quality of evidence for both specificity and sensitivity was low because of heterogeneity and risk of bias. Conclusion The level of diagnostic agreement between LUS and CT in the diagnosis of interstitial pneumonia caused by COVID-19 is high. LUS can be therefore considered as an equally accurate alternative for CT in situations where molecular tests are not available.
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spelling pubmed-83946422021-08-28 A Comparison of Lung Ultrasound and Computed Tomography in the Diagnosis of Patients with COVID-19: A Systematic Review and Meta-Analysis Wang, Mengshu Luo, Xufei Wang, Ling Estill, Janne Lv, Meng Zhu, Ying Wang, Qi Xiao, Xiaojuan Song, Yang Lee, Myeong Soo Ahn, Hyeong Sik Lei, Junqiang Tian, Jinhui Diagnostics (Basel) Systematic Review Background Lung ultrasound (LUS) and computed tomography (CT) can both be used for diagnosis of interstitial pneumonia caused by coronavirus disease 2019 (COVID-19), but the agreement between LUS and CT is unknown. Purpose to compare the agreement of LUS and CT in the diagnosis of interstitial pneumonia caused by COVID-19. Materials and Methods We searched PubMed, Cochrane library, Embase, Chinese Biomedicine Literature, and WHO COVID-19 databases to identify studies that compared LUS with CT in the diagnosis of interstitial pneumonia caused by COVID-19. We calculated the pooled overall, positive and negative percent agreements, diagnostic odds ratio (DOR) and the area under the standard receiver operating curve (SROC) for LUS in the diagnosis of COVID-19 compared with CT. Results We identified 1896 records, of which nine studies involving 531 patients were finally included. The pooled overall, positive and negative percentage agreements of LUS for the diagnosis of interstitial pneumonia caused by COVID-19 compared with CT were 81% (95% confidence interval [CI] 43–99%), 96% (95% CI, 80–99%, I(2) = 92.15%) and 80% (95%CI, 60–92%, I(2) = 92.85%), respectively. DOR was 37.41 (95% CI, 9.43–148.49, I(2) = 63.9%), and the area under the SROC curve was 0.94 (95% CI, 0.92–0.96). The quality of evidence for both specificity and sensitivity was low because of heterogeneity and risk of bias. Conclusion The level of diagnostic agreement between LUS and CT in the diagnosis of interstitial pneumonia caused by COVID-19 is high. LUS can be therefore considered as an equally accurate alternative for CT in situations where molecular tests are not available. MDPI 2021-07-27 /pmc/articles/PMC8394642/ /pubmed/34441286 http://dx.doi.org/10.3390/diagnostics11081351 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Wang, Mengshu
Luo, Xufei
Wang, Ling
Estill, Janne
Lv, Meng
Zhu, Ying
Wang, Qi
Xiao, Xiaojuan
Song, Yang
Lee, Myeong Soo
Ahn, Hyeong Sik
Lei, Junqiang
Tian, Jinhui
A Comparison of Lung Ultrasound and Computed Tomography in the Diagnosis of Patients with COVID-19: A Systematic Review and Meta-Analysis
title A Comparison of Lung Ultrasound and Computed Tomography in the Diagnosis of Patients with COVID-19: A Systematic Review and Meta-Analysis
title_full A Comparison of Lung Ultrasound and Computed Tomography in the Diagnosis of Patients with COVID-19: A Systematic Review and Meta-Analysis
title_fullStr A Comparison of Lung Ultrasound and Computed Tomography in the Diagnosis of Patients with COVID-19: A Systematic Review and Meta-Analysis
title_full_unstemmed A Comparison of Lung Ultrasound and Computed Tomography in the Diagnosis of Patients with COVID-19: A Systematic Review and Meta-Analysis
title_short A Comparison of Lung Ultrasound and Computed Tomography in the Diagnosis of Patients with COVID-19: A Systematic Review and Meta-Analysis
title_sort comparison of lung ultrasound and computed tomography in the diagnosis of patients with covid-19: a systematic review and meta-analysis
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394642/
https://www.ncbi.nlm.nih.gov/pubmed/34441286
http://dx.doi.org/10.3390/diagnostics11081351
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