The Anterior GRadient (AGR) family proteins in epithelial ovarian cancer

Epithelial ovarian cancer (EOC) is the most common gynecologic disorder. Even with the recent progresses made towards the use of new therapeutics, it still represents the most lethal gynecologic malignancy in women from developed countries. The discovery of the anterior gradient proteins AGR2 and AG...

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Autores principales: Fessart, Delphine, Robert, Jacques, Hartog, Cecile, Chevet, Eric, Delom, Frederic, Babin, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394676/
https://www.ncbi.nlm.nih.gov/pubmed/34452625
http://dx.doi.org/10.1186/s13046-021-02060-z
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author Fessart, Delphine
Robert, Jacques
Hartog, Cecile
Chevet, Eric
Delom, Frederic
Babin, Guillaume
author_facet Fessart, Delphine
Robert, Jacques
Hartog, Cecile
Chevet, Eric
Delom, Frederic
Babin, Guillaume
author_sort Fessart, Delphine
collection PubMed
description Epithelial ovarian cancer (EOC) is the most common gynecologic disorder. Even with the recent progresses made towards the use of new therapeutics, it still represents the most lethal gynecologic malignancy in women from developed countries. The discovery of the anterior gradient proteins AGR2 and AGR3, which are highly related members belonging to the protein disulfide isomerase (PDI) family, attracted researchers’ attention due to their putative involvement in adenocarcinoma development. This review compiles the current knowledge on the role of the AGR family and the expression of its members in EOC and discusses the potential clinical relevance of AGR2 and AGR3 for EOC diagnosis, prognosis, and therapeutics. A better understanding of the role of the AGR family may thus provide new handling avenues for EOC patients.
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spelling pubmed-83946762021-08-30 The Anterior GRadient (AGR) family proteins in epithelial ovarian cancer Fessart, Delphine Robert, Jacques Hartog, Cecile Chevet, Eric Delom, Frederic Babin, Guillaume J Exp Clin Cancer Res Review Epithelial ovarian cancer (EOC) is the most common gynecologic disorder. Even with the recent progresses made towards the use of new therapeutics, it still represents the most lethal gynecologic malignancy in women from developed countries. The discovery of the anterior gradient proteins AGR2 and AGR3, which are highly related members belonging to the protein disulfide isomerase (PDI) family, attracted researchers’ attention due to their putative involvement in adenocarcinoma development. This review compiles the current knowledge on the role of the AGR family and the expression of its members in EOC and discusses the potential clinical relevance of AGR2 and AGR3 for EOC diagnosis, prognosis, and therapeutics. A better understanding of the role of the AGR family may thus provide new handling avenues for EOC patients. BioMed Central 2021-08-27 /pmc/articles/PMC8394676/ /pubmed/34452625 http://dx.doi.org/10.1186/s13046-021-02060-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Fessart, Delphine
Robert, Jacques
Hartog, Cecile
Chevet, Eric
Delom, Frederic
Babin, Guillaume
The Anterior GRadient (AGR) family proteins in epithelial ovarian cancer
title The Anterior GRadient (AGR) family proteins in epithelial ovarian cancer
title_full The Anterior GRadient (AGR) family proteins in epithelial ovarian cancer
title_fullStr The Anterior GRadient (AGR) family proteins in epithelial ovarian cancer
title_full_unstemmed The Anterior GRadient (AGR) family proteins in epithelial ovarian cancer
title_short The Anterior GRadient (AGR) family proteins in epithelial ovarian cancer
title_sort anterior gradient (agr) family proteins in epithelial ovarian cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394676/
https://www.ncbi.nlm.nih.gov/pubmed/34452625
http://dx.doi.org/10.1186/s13046-021-02060-z
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