Cargando…

Effects of Mild Excitotoxic Stimulus on Mitochondria Ca(2+) Handling in Hippocampal Cultures of a Mouse Model of Alzheimer’s Disease

In Alzheimer’s disease (AD), the molecular mechanisms involved in the neurodegeneration are still incompletely defined, though this aspect is crucial for a better understanding of the malady and for devising effective therapies. Mitochondrial dysfunctions and altered Ca(2+) signaling have long been...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rigotto, Giulia, Zentilin, Lorena, Pozzan, Tullio, Basso, Emy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394681/ https://www.ncbi.nlm.nih.gov/pubmed/34440815 http://dx.doi.org/10.3390/cells10082046

Ejemplares similares

Mitochondrial Dysfunctions: A Thread Sewing Together Alzheimer's Disease, Diabetes, and Obesity
por: Rigotto, Giulia, et al.
Publicado: (2019)

Presenilin-2 and Calcium Handling: Molecules, Organelles, Cells and Brain Networks
por: Pizzo, Paola, et al.
Publicado: (2020)

In vivo monitoring of Ca(2+) uptake into mitochondria of mouse skeletal muscle during contraction
por: Rudolf, Rüdiger, et al.
Publicado: (2004)

Calcium Signaling and Mitochondrial Function in Presenilin 2 Knock-Out Mice: Looking for Any Loss-of-Function Phenotype Related to Alzheimer’s Disease
por: Rossi, Alice, et al.
Publicado: (2021)

New Linear Precursors of cIDPR Derivatives as Stable Analogs of cADPR: A Potent Second Messenger with Ca(2+)-Modulating Activity Isolated from Sea Urchin Eggs
por: D’Errico, Stefano, et al.
Publicado: (2019)

Ca(2+) Homeostasis in the Agonist-sensitive Internal Store: Functional Interactions Between Mitochondria and the ER Measured In Situ in Intact Cells
por: Landolfi, Barbara, et al.
Publicado: (1998)

Neuroprotective function for ramified microglia in hippocampal excitotoxicity
por: Vinet, Jonathan, et al.
Publicado: (2012)

Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration
por: Verma, Manish, et al.
Publicado: (2022)

Change of Nurr1 expression in mouse hippocampal CA3 region following excitotoxic neuronal damage
por: Lee, Choong-Hyun
Publicado: (2020)

Contrasting Contributions of Endoplasmic Reticulum and Mitochondria to Ca(2)+ Handling in Neurons
por: Barrett, Ellen F.
Publicado: (2001)

Capacitative Ca(2+) Entry Is Closely Linked to the Filling State of Internal Ca(2+) Stores: A Study Using Simultaneous Measurements of I(CRAC) and Intraluminal [Ca(2+)]
por: Hofer, Aldebaran M., et al.
Publicado: (1998)

The Heterogeneity of ER Ca(2+) Stores Has a Key Role in Nonmuscle Cell Signaling and Function
por: Meldolesi, Jacopo, et al.
Publicado: (1998)

Glutamate Transporters in Hippocampal LTD/LTP: Not Just Prevention of Excitotoxicity
por: Gonçalves-Ribeiro, Joana, et al.
Publicado: (2019)

Excitotoxic Insult Results in a Long-Lasting Activation of CaMKIIα and Mitochondrial Damage in Living Hippocampal Neurons
por: Otmakhov, Nikolai, et al.
Publicado: (2015)

Role of the Proteasome in Excitotoxicity-Induced Cleavage of Glutamic Acid Decarboxylase in Cultured Hippocampal Neurons
por: Baptista, Márcio S., et al.
Publicado: (2010)

Inhibition of Mg(2+) Extrusion Attenuates Glutamate Excitotoxicity in Cultured Rat Hippocampal Neurons
por: Shindo, Yutaka, et al.
Publicado: (2020)

Presenilin-2 dampens intracellular Ca(2+) stores by increasing Ca(2+) leakage and reducing Ca(2+) uptake
por: Brunello, Lucia, et al.
Publicado: (2009)

Mitochondria, Bioenergetics and Excitotoxicity: New Therapeutic Targets in Perinatal Brain Injury
por: Leaw, Bryan, et al.
Publicado: (2017)

mCerulean3-Based Cameleon Sensor to Explore Mitochondrial Ca(2+) Dynamics In Vivo
por: Greotti, Elisa, et al.
Publicado: (2019)

Calcium Elevation in Mitochondria Is the Main Ca(2+) Requirement for Mitochondrial Permeability Transition Pore (mPTP) Opening
por: Baumgartner, Heidi K., et al.
Publicado: (2009)

Brief low [Mg(2+)](o)-induced Ca(2+) spikes inhibit subsequent prolonged exposure-induced excitotoxicity in cultured rat hippocampal neurons
por: Kim, Hee Jung, et al.
Publicado: (2016)

Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration
por: Rodriguez-Rodriguez, P, et al.
Publicado: (2012)

Neuroprotective Potential of Biphalin, Multireceptor Opioid Peptide, Against Excitotoxic Injury in Hippocampal Organotypic Culture
por: Kawalec, Maria, et al.
Publicado: (2011)

Neuroprotective Effect of AM404 Against NMDA-Induced Hippocampal Excitotoxicity
por: Saliba, Soraya Wilke, et al.
Publicado: (2019)

mCerulean3-Based Cameleon Sensor to Explore Mitochondrial Ca(2+) Dynamics In Vivo
por: Greotti, Elisa, et al.
Publicado: (2019)

Direct in vivo monitoring of sarcoplasmic reticulum Ca(2+) and cytosolic cAMP dynamics in mouse skeletal muscle
por: Rudolf, Rüdiger, et al.
Publicado: (2006)

Termination of cAMP signals by Ca(2+) and Gα(i) via extracellular Ca(2+) sensors: a link to intracellular Ca(2+) oscillations
por: Gerbino, Andrea, et al.
Publicado: (2005)

Presenilin 1 Regulates [Ca(2+)]i and Mitochondria/ER Interaction in Cultured Rat Hippocampal Neurons
por: Korkotian, Eduard, et al.
Publicado: (2019)

Loss of forebrain MTCH2 decreases mitochondria motility and calcium handling and impairs hippocampal-dependent cognitive functions
por: Ruggiero, Antonella, et al.
Publicado: (2017)

Reduction of Mitophagy-Related Oxidative Stress and Preservation of Mitochondria Function Using Melatonin Therapy in an HT22 Hippocampal Neuronal Cell Model of Glutamate-Induced Excitotoxicity
por: Wang, Dan-dan, et al.
Publicado: (2019)

Obesity Resistance Promotes Mild Contractile Dysfunction Associated with Intracellular Ca(2+) Handling
por: de Sá, Felipe Gonçalves dos Santos, et al.
Publicado: (2015)

Characterization of the ER-Targeted Low Affinity Ca(2+) Probe D4ER
por: Greotti, Elisa, et al.
Publicado: (2016)

Ca(2+) Homeostasis in the Endoplasmic Reticulum: Coexistence of High and Low [Ca(2+)] Subcompartments in Intact HeLa Cells
por: Montero, Mayte, et al.
Publicado: (1997)

Excitotoxicity Triggered by Neurobasal Culture Medium
por: Hogins, Joshua, et al.
Publicado: (2011)

Intracellular Calcium Dysregulation by the Alzheimer’s Disease-Linked Protein Presenilin 2
por: Galla, Luisa, et al.
Publicado: (2020)

Fructose-1,6-Bisphosphate Protects Hippocampal Rat Slices from NMDA Excitotoxicity
por: Yakoub, Kamal M., et al.
Publicado: (2019)

Selectivity of stimulus induced responses in cultured hippocampal networks on microelectrode arrays
por: Pimashkin, Alexey, et al.
Publicado: (2016)

Reduced Loading of Intracellular Ca(2+) Stores and Downregulation of Capacitative Ca(2+)Influx in Bcl-2–Overexpressing Cells
por: Pinton, Paolo, et al.
Publicado: (2000)

No effect of hippocampal lesions on stimulus-response bindings
por: Henson, Richard N., et al.
Publicado: (2017)

Generation and Characterization of a New FRET-Based Ca(2+) Sensor Targeted to the Nucleus
por: Galla, Luisa, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_92pifdlripi15jh3v2nls38hm0