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DNA-Dependent Protein Kinase Catalytic Subunit: The Sensor for DNA Double-Strand Breaks Structurally and Functionally Related to Ataxia Telangiectasia Mutated

The DNA-dependent protein kinase (DNA-PK) is composed of a DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and Ku70/Ku80 heterodimer. DNA-PK is thought to act as the “sensor” for DNA double-stranded breaks (DSB), which are considered the most deleterious type of DNA damage. In particular,...

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Detalles Bibliográficos
Autores principales:	Matsumoto, Yoshihisa, Asa, Anie Day D. C., Modak, Chaity, Shimada, Mikio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394720/ https://www.ncbi.nlm.nih.gov/pubmed/34440313 http://dx.doi.org/10.3390/genes12081143

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