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Biomedical Relevance of Novel Anticancer Peptides in the Sensitive Treatment of Cancer

The global increase in cancer mortality and economic losses necessitates the cautious quest for therapeutic agents with compensatory advantages over conventional therapies. Anticancer peptides (ACPs) are a subset of host defense peptides, also known as antimicrobial peptides, which have emerged as t...

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Detalles Bibliográficos
Autores principales: Bakare, Olalekan Olanrewaju, Gokul, Arun, Wu, Ruomou, Niekerk, Lee-Ann, Klein, Ashwil, Keyster, Marshall
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394746/
https://www.ncbi.nlm.nih.gov/pubmed/34439786
http://dx.doi.org/10.3390/biom11081120
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author Bakare, Olalekan Olanrewaju
Gokul, Arun
Wu, Ruomou
Niekerk, Lee-Ann
Klein, Ashwil
Keyster, Marshall
author_facet Bakare, Olalekan Olanrewaju
Gokul, Arun
Wu, Ruomou
Niekerk, Lee-Ann
Klein, Ashwil
Keyster, Marshall
author_sort Bakare, Olalekan Olanrewaju
collection PubMed
description The global increase in cancer mortality and economic losses necessitates the cautious quest for therapeutic agents with compensatory advantages over conventional therapies. Anticancer peptides (ACPs) are a subset of host defense peptides, also known as antimicrobial peptides, which have emerged as therapeutic and diagnostic candidates due to several compensatory advantages over the non-specificity of the current treatment regimens. This review aimed to highlight the ravaging incidence of cancer, the use of ACPs in cancer treatment with their mechanisms, ACP discovery and delivery methods, and the limitations for their use. This would create awareness for identifying more ACPs with better specificity, accuracy and sensitivity towards the disease. It would also promote their efficacious utilization in biotechnology, medical sciences and molecular biology to ease the severity of the disease and enable the patients living with these conditions to develop an accommodating lifestyle.
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spelling pubmed-83947462021-08-28 Biomedical Relevance of Novel Anticancer Peptides in the Sensitive Treatment of Cancer Bakare, Olalekan Olanrewaju Gokul, Arun Wu, Ruomou Niekerk, Lee-Ann Klein, Ashwil Keyster, Marshall Biomolecules Review The global increase in cancer mortality and economic losses necessitates the cautious quest for therapeutic agents with compensatory advantages over conventional therapies. Anticancer peptides (ACPs) are a subset of host defense peptides, also known as antimicrobial peptides, which have emerged as therapeutic and diagnostic candidates due to several compensatory advantages over the non-specificity of the current treatment regimens. This review aimed to highlight the ravaging incidence of cancer, the use of ACPs in cancer treatment with their mechanisms, ACP discovery and delivery methods, and the limitations for their use. This would create awareness for identifying more ACPs with better specificity, accuracy and sensitivity towards the disease. It would also promote their efficacious utilization in biotechnology, medical sciences and molecular biology to ease the severity of the disease and enable the patients living with these conditions to develop an accommodating lifestyle. MDPI 2021-07-29 /pmc/articles/PMC8394746/ /pubmed/34439786 http://dx.doi.org/10.3390/biom11081120 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bakare, Olalekan Olanrewaju
Gokul, Arun
Wu, Ruomou
Niekerk, Lee-Ann
Klein, Ashwil
Keyster, Marshall
Biomedical Relevance of Novel Anticancer Peptides in the Sensitive Treatment of Cancer
title Biomedical Relevance of Novel Anticancer Peptides in the Sensitive Treatment of Cancer
title_full Biomedical Relevance of Novel Anticancer Peptides in the Sensitive Treatment of Cancer
title_fullStr Biomedical Relevance of Novel Anticancer Peptides in the Sensitive Treatment of Cancer
title_full_unstemmed Biomedical Relevance of Novel Anticancer Peptides in the Sensitive Treatment of Cancer
title_short Biomedical Relevance of Novel Anticancer Peptides in the Sensitive Treatment of Cancer
title_sort biomedical relevance of novel anticancer peptides in the sensitive treatment of cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394746/
https://www.ncbi.nlm.nih.gov/pubmed/34439786
http://dx.doi.org/10.3390/biom11081120
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