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Preventing Biofilm Formation and Development on Ear, Nose and Throat Medical Devices

Otorhinolaryngology is a vast domain that requires the aid of many resources for optimal performance. The medical devices utilized in this branch share common problems, such as the formation of biofilms. These structured communities of microbes encased in a 3D matrix can develop antimicrobial resist...

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Autores principales: Gheorghe, Dan Cristian, Ilie, Andrei, Niculescu, Adelina-Gabriela, Grumezescu, Alexandru Mihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394763/
https://www.ncbi.nlm.nih.gov/pubmed/34440229
http://dx.doi.org/10.3390/biomedicines9081025
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author Gheorghe, Dan Cristian
Ilie, Andrei
Niculescu, Adelina-Gabriela
Grumezescu, Alexandru Mihai
author_facet Gheorghe, Dan Cristian
Ilie, Andrei
Niculescu, Adelina-Gabriela
Grumezescu, Alexandru Mihai
author_sort Gheorghe, Dan Cristian
collection PubMed
description Otorhinolaryngology is a vast domain that requires the aid of many resources for optimal performance. The medical devices utilized in this branch share common problems, such as the formation of biofilms. These structured communities of microbes encased in a 3D matrix can develop antimicrobial resistance (AMR), thus making it a problem with challenging solutions. Therefore, it is of concern the introduction in the medical practice involving biomaterials for ear, nose and throat (ENT) devices, such as implants for the trachea (stents), ear (cochlear implants), and voice recovery (voice prosthetics). The surface of these materials must be biocompatible and limit the development of biofilm while still promoting regeneration. In this respect, several surface modification techniques and functionalization procedures can be utilized to facilitate the success of the implants and ensure a long time of use. On this note, this review provides information on the intricate underlying mechanisms of biofilm formation, the large specter of implants and prosthetics that are susceptible to microbial colonization and subsequently related infections. Specifically, the discussion is particularized on biofilm development on ENT devices, ways to reduce it, and recent approaches that have emerged in this field.
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spelling pubmed-83947632021-08-28 Preventing Biofilm Formation and Development on Ear, Nose and Throat Medical Devices Gheorghe, Dan Cristian Ilie, Andrei Niculescu, Adelina-Gabriela Grumezescu, Alexandru Mihai Biomedicines Review Otorhinolaryngology is a vast domain that requires the aid of many resources for optimal performance. The medical devices utilized in this branch share common problems, such as the formation of biofilms. These structured communities of microbes encased in a 3D matrix can develop antimicrobial resistance (AMR), thus making it a problem with challenging solutions. Therefore, it is of concern the introduction in the medical practice involving biomaterials for ear, nose and throat (ENT) devices, such as implants for the trachea (stents), ear (cochlear implants), and voice recovery (voice prosthetics). The surface of these materials must be biocompatible and limit the development of biofilm while still promoting regeneration. In this respect, several surface modification techniques and functionalization procedures can be utilized to facilitate the success of the implants and ensure a long time of use. On this note, this review provides information on the intricate underlying mechanisms of biofilm formation, the large specter of implants and prosthetics that are susceptible to microbial colonization and subsequently related infections. Specifically, the discussion is particularized on biofilm development on ENT devices, ways to reduce it, and recent approaches that have emerged in this field. MDPI 2021-08-16 /pmc/articles/PMC8394763/ /pubmed/34440229 http://dx.doi.org/10.3390/biomedicines9081025 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gheorghe, Dan Cristian
Ilie, Andrei
Niculescu, Adelina-Gabriela
Grumezescu, Alexandru Mihai
Preventing Biofilm Formation and Development on Ear, Nose and Throat Medical Devices
title Preventing Biofilm Formation and Development on Ear, Nose and Throat Medical Devices
title_full Preventing Biofilm Formation and Development on Ear, Nose and Throat Medical Devices
title_fullStr Preventing Biofilm Formation and Development on Ear, Nose and Throat Medical Devices
title_full_unstemmed Preventing Biofilm Formation and Development on Ear, Nose and Throat Medical Devices
title_short Preventing Biofilm Formation and Development on Ear, Nose and Throat Medical Devices
title_sort preventing biofilm formation and development on ear, nose and throat medical devices
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394763/
https://www.ncbi.nlm.nih.gov/pubmed/34440229
http://dx.doi.org/10.3390/biomedicines9081025
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