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Analogs of a Natural Peptaibol Exert Anticancer Activity in Both Cisplatin- and Doxorubicin-Resistant Cells and in Multicellular Tumor Spheroids

Peptaibols, by disturbing the permeability of phospholipid membranes, can overcome anticancer drug resistance, but their natural hydrophobicity hampers their administration. By a green peptide synthesis protocol, we produced two water-soluble analogs of the peptaibol trichogin GA IV, termed K6-Lol a...

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Detalles Bibliográficos
Autores principales:	Casagrande, Naike, Borghese, Cinzia, Gabbatore, Laura, Morbiato, Laura, De Zotti, Marta, Aldinucci, Donatella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394784/ https://www.ncbi.nlm.nih.gov/pubmed/34445069 http://dx.doi.org/10.3390/ijms22168362

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