Cargando…

Structural Dissection of Viral Spike-Protein Binding of SARS-CoV-2 and SARS-CoV-1 to the Human Angiotensin-Converting Enzyme 2 (ACE2) as Cellular Receptor

An outbreak by a new severe acute respiratory syndrome betacoronavirus (SARS-CoV-2) has spread CoronaVirus Disease 2019 (COVID-19) all over the world. Immediately, following studies have confirmed the human Angiotensin-Converting Enzyme 2 (ACE2) as a cellular receptor of viral Spike-Protein (Sp) tha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Giordano, Deborah, De Masi, Luigi, Argenio, Maria Antonia, Facchiano, Angelo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394803/ https://www.ncbi.nlm.nih.gov/pubmed/34440241 http://dx.doi.org/10.3390/biomedicines9081038

Ejemplares similares

The Race for ACE: Targeting Angiotensin-Converting Enzymes (ACE) in SARS-CoV-2 Infection
por: Schieffer, Elisabeth, et al.
Publicado: (2022)

Potential therapeutic approaches for the early entry of SARS-CoV-2 by interrupting the interaction between the spike protein on SARS-CoV-2 and angiotensin-converting enzyme 2 (ACE2)
por: Xiang, Yusen, et al.
Publicado: (2021)

Angiotensin-converting enzyme 2 (ACE2): SARS-CoV-2 receptor and RAS modulator
por: Bian, Jingwei, et al.
Publicado: (2021)

SARS-CoV-2, the Angiotensin Converting Enzyme 2 (ACE2) Receptor and Alzheimer’s disease
por: Lukiw, Walter J.
Publicado: (2021)

Predicting the angiotensin converting enzyme 2 (ACE2) utilizing capability as the receptor of SARS-CoV-2
por: Qiu, Ye, et al.
Publicado: (2020)

Angiotensin-converting enzyme 2 (ACE2) receptor and SARS-CoV-2: Potential therapeutic targeting
por: Sharifkashani, Sourena, et al.
Publicado: (2020)

Synthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein
por: Sadremomtaz, Afsaneh, et al.
Publicado: (2021)

Computational optimization of angiotensin-converting enzyme 2 for SARS-CoV-2 Spike molecular recognition
por: Di Rienzo, Lorenzo, et al.
Publicado: (2021)

Comprehensive Structural and Molecular Comparison of Spike Proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and Their Interactions with ACE2
por: Hatmal, Ma’mon M., et al.
Publicado: (2020)

Exploring the Mystery of Angiotensin-Converting Enzyme II (ACE2) in the Battle against SARS-CoV-2
por: Sharma, Divakar, et al.
Publicado: (2021)

Dynamics of the ACE2–SARS-CoV-2/SARS-CoV spike protein interface reveal unique mechanisms
por: Ali, Amanat, et al.
Publicado: (2020)

Spike Proteins of SARS-CoV and SARS-CoV-2 Utilize Different Mechanisms to Bind With Human ACE2
por: Xie, Yixin, et al.
Publicado: (2020)

Structural dynamic changes in the SARS-CoV and SARS-CoV-2 S spike assemblies upon ACE2 activation
por: Chen, Chengbo, et al.
Publicado: (2022)

Mutants of human ACE2 differentially promote SARS-CoV and SARS-CoV-2 spike mediated infection
por: Shukla, Nidhi, et al.
Publicado: (2021)

A novel rapid detection for SARS-CoV-2 spike 1 antigens using human angiotensin converting enzyme 2 (ACE2)
por: Lee, Jong-Hwan, et al.
Publicado: (2021)

Interactions of angiotensin-converting enzyme-2 (ACE2) and SARS-CoV-2 spike receptor-binding domain (RBD): a structural perspective
por: Borkotoky, Subhomoi, et al.
Publicado: (2022)

An angiotensin-converting enzyme-2-derived heptapeptide GK-7 for SARS-CoV-2 spike blockade
por: Han, Songling, et al.
Publicado: (2021)

SARS-CoV-2 spike and ACE2 entanglement-like binding
por: Pregnolato, Massimo, et al.
Publicado: (2023)

The pH Effects on SARS-CoV and SARS-CoV-2 Spike Proteins in the Process of Binding to hACE2
por: Xie, Yixin, et al.
Publicado: (2021)

The pH Effects on SARS-CoV and SARS-CoV-2 Spike Proteins in the Process of Binding to hACE2
por: Xie, Yixin, et al.
Publicado: (2022)

Mechanistic Origin of Different Binding Affinities of SARS-CoV and SARS-CoV-2 Spike RBDs to Human ACE2
por: Zhang, Zhi-Bi, et al.
Publicado: (2022)

Azelastine inhibits viropexis of SARS-CoV-2 spike pseudovirus by binding to SARS-CoV-2 entry receptor ACE2
por: Ge, Shuai, et al.
Publicado: (2021)

Angiotensin‐converting enzyme 2 (ACE2), SARS‐CoV‐2 and the pathophysiology of coronavirus disease 2019 (COVID‐19)
por: Bourgonje, Arno R, et al.
Publicado: (2020)

COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection
por: Beyerstedt, Stephany, et al.
Publicado: (2021)

In silico investigation of critical binding pattern in SARS-CoV-2 spike protein with angiotensin-converting enzyme 2
por: Jafary, Farzaneh, et al.
Publicado: (2021)

SARS-CoV-2 spike protein variant binding affinity to an angiotensin-converting enzyme 2 fusion glycoproteins
por: Matthews, Alicia M., et al.
Publicado: (2022)

Thermodynamic analysis of the interactions between human ACE2 and spike RBD of Betacoronaviruses (SARS‐CoV‐1 and SARS‐CoV‐2)
por: Rombel‐Bryzek, Agnieszka, et al.
Publicado: (2022)

Angiotensin-Converting Enzyme 2 Expression and Severity of SARS-CoV-2 Infection
por: Alabsi, Sarah, et al.
Publicado: (2023)

Revealing the Mechanism of SARS-CoV-2 Spike Protein Binding With ACE2
Publicado: (2020)

SARS-CoV-2 electrochemical immunosensor based on the spike-ACE2 complex
por: Vásquez, Viviana, et al.
Publicado: (2022)

Mechanism and evolution of human ACE2 binding by SARS-CoV-2 spike
por: Wrobel, Antoni G.
Publicado: (2023)

Design and Identification of Inhibitors for the Spike-ACE2 Target of SARS-CoV-2
por: Bastos, Ruan S., et al.
Publicado: (2023)

An efficient system to generate truncated human angiotensin converting enzyme 2 (hACE2) capable of binding RBD and spike protein of SARS-CoV2
por: Gao, Xiangzheng, et al.
Publicado: (2021)

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target
por: Zhang, Haibo, et al.
Publicado: (2020)

A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor
por: Oz, Murat, et al.
Publicado: (2021)

Angiotensin-converting enzyme 2 (ACE2) polymorphisms and susceptibility of severe SARS-CoV-2 in a subset of Pakistani population
por: Sidhwani, Santosh Kumar, et al.
Publicado: (2023)

On the interactions of the receptor-binding domain of SARS-CoV-1 and SARS-CoV-2 spike proteins with monoclonal antibodies and the receptor ACE2
por: Corrêa Giron, Carolina, et al.
Publicado: (2020)

hACE2-Induced Allosteric Activation in SARS-CoV versus SARS-CoV-2 Spike Assemblies Revealed by Structural Dynamics
por: Chen, Chengbo, et al.
Publicado: (2023)

Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2–ACE2 Receptor Interactions
por: Day, Christopher J., et al.
Publicado: (2021)

SARS-CoV-2 Spike Protein Regulation of Angiotensin Converting Enzyme 2 and Tissue Renin-Angiotensin Systems: Influence of Biologic Sex
por: Ensor, Charles M., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_24q1s89vu8gv13daa6nmrqfrv7