Cargando…

Multiple-Organ Complement Deposition on Vascular Endothelium in COVID-19 Patients

Increased levels of circulating complement activation products have been reported in COVID-19 patients, but only limited information is available on complement involvement at the tissue level. The mechanisms and pathways of local complement activation remain unclear. The aim of this study was to inv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Macor, Paolo, Durigutto, Paolo, Mangogna, Alessandro, Bussani, Rossana, De Maso, Luca, D’Errico, Stefano, Zanon, Martina, Pozzi, Nicola, Meroni, Pier Luigi, Tedesco, Francesco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394811/ https://www.ncbi.nlm.nih.gov/pubmed/34440207 http://dx.doi.org/10.3390/biomedicines9081003

Ejemplares similares

Targeted Delivery of Neutralizing Anti-C5 Antibody to Renal Endothelium Prevents Complement-Dependent Tissue Damage
por: Durigutto, Paolo, et al.
Publicado: (2017)

Prevention of Arthritis by Locally Synthesized Recombinant Antibody Neutralizing Complement Component C5
por: Durigutto, Paolo, et al.
Publicado: (2013)

New insight into antiphospholipid syndrome: antibodies to β2glycoprotein I-domain 5 fail to induce thrombi in rats
por: Durigutto, Paolo, et al.
Publicado: (2019)

Pathogenic Role of Complement in Antiphospholipid Syndrome and Therapeutic Implications
por: Tedesco, Francesco, et al.
Publicado: (2018)

Complement as a Biological Tool to Control Tumor Growth
por: Macor, Paolo, et al.
Publicado: (2018)

A novel complement-fixing IgM antibody targeting GPC1 as a useful immunotherapeutic strategy for the treatment of pancreatic ductal adenocarcinoma
por: Busato, Davide, et al.
Publicado: (2023)

An allosteric redox switch in domain V of β(2)-glycoprotein I controls membrane binding and anti-domain I autoantibody recognition
por: Kumar, Suresh, et al.
Publicado: (2021)

Plasminogen activator-coated nanobubbles targeting cell-bound β2-glycoprotein I as a novel thrombus-specific thrombolytic strategy
por: Macor, Paolo, et al.
Publicado: (2022)

C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation
por: Bulla, Roberta, et al.
Publicado: (2016)

Soluble CD59 Expressed from an Adenovirus In Vivo Is a Potent Inhibitor of Complement Deposition on Murine Liver Vascular Endothelium
por: Gandhi, Jarel, et al.
Publicado: (2011)

Design, Synthesis and Characterization of Novel Co-Polymers Decorated with Peptides for the Selective Nanoparticle Transport across the Cerebral Endothelium
por: Falanga, Andrea P., et al.
Publicado: (2018)

The Complement System in the Pathophysiology of Pregnancy and in Systemic Autoimmune Rheumatic Diseases During Pregnancy
por: Chighizola, Cecilia Beatrice, et al.
Publicado: (2020)

Invasive meningococcal disease in three siblings with hereditary deficiency of the 8(th) component of complement: evidence for the importance of an early diagnosis
por: Dellepiane, Rosa Maria, et al.
Publicado: (2016)

Synthetic Cannabinoids and Cathinones Cardiotoxicity: Facts andPerspectives
por: Radaelli, Davide, et al.
Publicado: (2021)

The Inflammatory Feed-Forward Loop Triggered by the Complement Component C3 as a Potential Target in Endometriosis
por: Agostinis, Chiara, et al.
Publicado: (2021)

Nanomechanics of vascular endothelium
por: Fels, Johannes, et al.
Publicado: (2014)

Malaria and Vascular Endothelium
por: de Alencar, Aristóteles Comte, et al.
Publicado: (2014)

Beta 2 glycoprotein I and neutrophil extracellular traps: Potential bridge between innate and adaptive immunity in anti-phospholipid syndrome
por: Grossi, Claudia, et al.
Publicado: (2023)

Complement-mediated regulation of tissue factor activity in endothelium
Publicado: (1995)

Complement activation in patients with COVID-19: A novel therapeutic target
por: Cugno, Massimo, et al.
Publicado: (2020)

Plasma complement and vascular complement deposition in patients with coronary artery disease with and without inflammatory rheumatic diseases
por: Shields, Kelly J., et al.
Publicado: (2017)

THE EFFECTS OF ENDOTOXIN ON VASCULAR ENDOTHELIUM
por: McGrath, J. M., et al.
Publicado: (1969)

The Vascular Endothelium and Human Diseases
por: Rajendran, Peramaiyan, et al.
Publicado: (2013)

Vascular Endothelium in Hemostasis and Thrombosis
por: Petty, Richard
Publicado: (1988)

Contributions of the Endothelium to Vascular Calcification
por: Zhang, Li, et al.
Publicado: (2021)

Distinct Roles of Classical and Lectin Pathways of Complement in Preeclamptic Placentae
por: Belmonte, Beatrice, et al.
Publicado: (2022)

HUMAN DEFINITIVE HAEMOGENIC ENDOTHELIUM AND ARTERIAL VASCULAR ENDOTHELIUM REPRESENT DISTINCT LINEAGES
por: Ditadi, Andrea, et al.
Publicado: (2015)

Vascular endothelium receptors and transduction mechanisms
por: Catravas, John, et al.
Publicado: (1989)

Studies on Solute Transfer in the Vascular Endothelium
por: Mende, Thomas J., et al.
Publicado: (1958)

Protection of the vascular endothelium in experimental situations
por: Sotníková, Ružena, et al.
Publicado: (2011)

Two barriers for sodium in vascular endothelium?
por: Oberleithner, Hans
Publicado: (2012)

Arginase in the Vascular Endothelium: Friend or Foe?
por: Lucas, Rudolf, et al.
Publicado: (2014)

The Endothelium and Endothelin: Beyond Vascular Reactivity
por: Hassan, Walid
Publicado: (2006)

Heterogeneity and emergent behaviour in the vascular endothelium
por: McCarron, John G, et al.
Publicado: (2019)

Endothelium — The Axis of Vascular Health and Disease
por: Petty, Richard G., et al.
Publicado: (1989)

Vascularized Microfluidics and the Blood–Endothelium Interface
por: Hesh, Christopher A., et al.
Publicado: (2019)

Glycocalyx–Sodium Interaction in Vascular Endothelium
por: Sembajwe, Lawrence Fred, et al.
Publicado: (2023)

The Model of “Informed Refusal” for Vaccination: How to Fight against Anti-Vaccinationist Misinformation without Disregarding the Principle of Self-Determination
por: D’Errico, Stefano, et al.
Publicado: (2021)

Complement activation predicts negative outcomes in COVID-19: The experience from Northen Italian patients.
por: Meroni, Pier Luigi, et al.
Publicado: (2023)

“First Do No Harm”. No-Fault Compensation Program for COVID-19 Vaccines as Feasibility and Wisdom of a Policy Instrument to Mitigate Vaccine Hesitancy
por: D’Errico, Stefano, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_akrb4rd54tt4fha6ef5369tvse