Variants of Concern Are Overrepresented Among Postvaccination Breakthrough Infections of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Washington State

Across 20 vaccine breakthrough cases detected at our institution, all 20 (100%) infections were due to variants of concern (VOCs) and had a median Ct of 20.2 (IQR, 17.1–23.3). When compared with 5174 contemporaneous samples sequenced in our laboratory, VOCs were significantly enriched among breakthr...

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Detalles Bibliográficos
Autores principales: McEwen, Abbye E, Cohen, Seth, Bryson-Cahn, Chloe, Liu, Catherine, Pergam, Steven A, Lynch, John, Schippers, Adrienne, Strand, Kathy, Whimbey, Estella, Mani, Nandita S, Zelikoff, Allison J, Makarewicz, Vanessa A, Brown, Elizabeth R, Bakhash, Shah A Mohamed, Baker, Noah R, Castor, Jared, Livingston, Robert J, Huang, Meei-Li, Jerome, Keith R, Greninger, Alexander L, Roychoudhury, Pavitra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394820/
https://www.ncbi.nlm.nih.gov/pubmed/34166484
http://dx.doi.org/10.1093/cid/ciab581
Descripción
Sumario:Across 20 vaccine breakthrough cases detected at our institution, all 20 (100%) infections were due to variants of concern (VOCs) and had a median Ct of 20.2 (IQR, 17.1–23.3). When compared with 5174 contemporaneous samples sequenced in our laboratory, VOCs were significantly enriched among breakthrough infections (P < .05).

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