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Rapidly Increasing Severe Acute Respiratory Syndrome Coronavirus 2 Seroprevalence and Limited Clinical Disease in 3 Malian Communities: A Prospective Cohort Study

BACKGROUND: The extent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure and transmission in Mali and the surrounding region is not well understood. We aimed to estimate the cumulative incidence of SARS-CoV-2 in 3 communities and understand factors associated with infection. M...

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Autores principales: Sagara, Issaka, Woodford, John, Kone, Mamady, Assadou, Mahamadoun Hamady, Katile, Abdoulaye, Attaher, Oumar, Zeguime, Amatigue, Doucoure, M’Bouye, Higbee, Emily, Lane, Jacquelyn, Mohan, Rathy, Doritchamou, Justin, Zaidi, Irfan, Esposito, Dominic, Kwan, Jennifer, Sadtler, Kaitlyn, Dicko, Alassane, Duffy, Patrick E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394825/
https://www.ncbi.nlm.nih.gov/pubmed/34185847
http://dx.doi.org/10.1093/cid/ciab589
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author Sagara, Issaka
Woodford, John
Kone, Mamady
Assadou, Mahamadoun Hamady
Katile, Abdoulaye
Attaher, Oumar
Zeguime, Amatigue
Doucoure, M’Bouye
Higbee, Emily
Lane, Jacquelyn
Mohan, Rathy
Doritchamou, Justin
Zaidi, Irfan
Esposito, Dominic
Kwan, Jennifer
Sadtler, Kaitlyn
Dicko, Alassane
Duffy, Patrick E
author_facet Sagara, Issaka
Woodford, John
Kone, Mamady
Assadou, Mahamadoun Hamady
Katile, Abdoulaye
Attaher, Oumar
Zeguime, Amatigue
Doucoure, M’Bouye
Higbee, Emily
Lane, Jacquelyn
Mohan, Rathy
Doritchamou, Justin
Zaidi, Irfan
Esposito, Dominic
Kwan, Jennifer
Sadtler, Kaitlyn
Dicko, Alassane
Duffy, Patrick E
author_sort Sagara, Issaka
collection PubMed
description BACKGROUND: The extent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure and transmission in Mali and the surrounding region is not well understood. We aimed to estimate the cumulative incidence of SARS-CoV-2 in 3 communities and understand factors associated with infection. METHODS: Between July 2020 and January 2021, we collected blood samples and demographic, social, medical, and self-reported symptoms information from residents aged 6 months and older over 2 study visits. SARS-CoV-2 antibodies were measured using a highly specific 2-antigen enzyme-linked immunosorbent assay optimized for use in Mali. We calculated cumulative adjusted seroprevalence for each community and evaluated factors associated with serostatus at each visit by univariate and multivariate analysis. RESULTS: Overall, 94.8% (2533/2672) of participants completed both study visits. A total of 31.3% (837/2672) were aged <10 years, 27.6% (737/2672) were aged 10–17 years, and 41.1% (1098/2572) were aged ≥18 years. The cumulative SARS-CoV-2 exposure rate was 58.5% (95% confidence interval, 47.5–69.4). This varied between sites and was 73.4% in the urban community of Sotuba, 53.2% in the rural town of Bancoumana, and 37.1% in the rural village of Donéguébougou. Study site and increased age were associated with serostatus at both study visits. There was minimal difference in reported symptoms based on serostatus. CONCLUSIONS: The true extent of SARS-CoV-2 exposure in Mali is greater than previously reported and may now approach hypothetical “herd immunity” in urban areas. The epidemiology of the pandemic in the region may be primarily subclinical and within background illness rates.
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spelling pubmed-83948252021-09-01 Rapidly Increasing Severe Acute Respiratory Syndrome Coronavirus 2 Seroprevalence and Limited Clinical Disease in 3 Malian Communities: A Prospective Cohort Study Sagara, Issaka Woodford, John Kone, Mamady Assadou, Mahamadoun Hamady Katile, Abdoulaye Attaher, Oumar Zeguime, Amatigue Doucoure, M’Bouye Higbee, Emily Lane, Jacquelyn Mohan, Rathy Doritchamou, Justin Zaidi, Irfan Esposito, Dominic Kwan, Jennifer Sadtler, Kaitlyn Dicko, Alassane Duffy, Patrick E Clin Infect Dis Major Articles and Commentaries BACKGROUND: The extent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure and transmission in Mali and the surrounding region is not well understood. We aimed to estimate the cumulative incidence of SARS-CoV-2 in 3 communities and understand factors associated with infection. METHODS: Between July 2020 and January 2021, we collected blood samples and demographic, social, medical, and self-reported symptoms information from residents aged 6 months and older over 2 study visits. SARS-CoV-2 antibodies were measured using a highly specific 2-antigen enzyme-linked immunosorbent assay optimized for use in Mali. We calculated cumulative adjusted seroprevalence for each community and evaluated factors associated with serostatus at each visit by univariate and multivariate analysis. RESULTS: Overall, 94.8% (2533/2672) of participants completed both study visits. A total of 31.3% (837/2672) were aged <10 years, 27.6% (737/2672) were aged 10–17 years, and 41.1% (1098/2572) were aged ≥18 years. The cumulative SARS-CoV-2 exposure rate was 58.5% (95% confidence interval, 47.5–69.4). This varied between sites and was 73.4% in the urban community of Sotuba, 53.2% in the rural town of Bancoumana, and 37.1% in the rural village of Donéguébougou. Study site and increased age were associated with serostatus at both study visits. There was minimal difference in reported symptoms based on serostatus. CONCLUSIONS: The true extent of SARS-CoV-2 exposure in Mali is greater than previously reported and may now approach hypothetical “herd immunity” in urban areas. The epidemiology of the pandemic in the region may be primarily subclinical and within background illness rates. Oxford University Press 2021-06-29 /pmc/articles/PMC8394825/ /pubmed/34185847 http://dx.doi.org/10.1093/cid/ciab589 Text en Published by Oxford University Press for the Infectious Diseases Society of America 2021. This work is written by (a) US Government employee(s) and is in the public domain in the US.
spellingShingle Major Articles and Commentaries
Sagara, Issaka
Woodford, John
Kone, Mamady
Assadou, Mahamadoun Hamady
Katile, Abdoulaye
Attaher, Oumar
Zeguime, Amatigue
Doucoure, M’Bouye
Higbee, Emily
Lane, Jacquelyn
Mohan, Rathy
Doritchamou, Justin
Zaidi, Irfan
Esposito, Dominic
Kwan, Jennifer
Sadtler, Kaitlyn
Dicko, Alassane
Duffy, Patrick E
Rapidly Increasing Severe Acute Respiratory Syndrome Coronavirus 2 Seroprevalence and Limited Clinical Disease in 3 Malian Communities: A Prospective Cohort Study
title Rapidly Increasing Severe Acute Respiratory Syndrome Coronavirus 2 Seroprevalence and Limited Clinical Disease in 3 Malian Communities: A Prospective Cohort Study
title_full Rapidly Increasing Severe Acute Respiratory Syndrome Coronavirus 2 Seroprevalence and Limited Clinical Disease in 3 Malian Communities: A Prospective Cohort Study
title_fullStr Rapidly Increasing Severe Acute Respiratory Syndrome Coronavirus 2 Seroprevalence and Limited Clinical Disease in 3 Malian Communities: A Prospective Cohort Study
title_full_unstemmed Rapidly Increasing Severe Acute Respiratory Syndrome Coronavirus 2 Seroprevalence and Limited Clinical Disease in 3 Malian Communities: A Prospective Cohort Study
title_short Rapidly Increasing Severe Acute Respiratory Syndrome Coronavirus 2 Seroprevalence and Limited Clinical Disease in 3 Malian Communities: A Prospective Cohort Study
title_sort rapidly increasing severe acute respiratory syndrome coronavirus 2 seroprevalence and limited clinical disease in 3 malian communities: a prospective cohort study
topic Major Articles and Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394825/
https://www.ncbi.nlm.nih.gov/pubmed/34185847
http://dx.doi.org/10.1093/cid/ciab589
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