Cargando…

Role of Long Non-Coding RNAs in Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is a debilitating condition of the pulmonary circulatory system that occurs in patients of all ages and if untreated, eventually leads to right heart failure and death. Despite existing medical treatment options that improve survival and quality of life, the dis...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Yun, Ali, Md Khadem, Dua, Kamal, Spiekerkoetter, Edda, Mao, Yuqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394897/
https://www.ncbi.nlm.nih.gov/pubmed/34440661
http://dx.doi.org/10.3390/cells10081892
_version_ 1783744050522750976
author Han, Yun
Ali, Md Khadem
Dua, Kamal
Spiekerkoetter, Edda
Mao, Yuqiang
author_facet Han, Yun
Ali, Md Khadem
Dua, Kamal
Spiekerkoetter, Edda
Mao, Yuqiang
author_sort Han, Yun
collection PubMed
description Pulmonary arterial hypertension (PAH) is a debilitating condition of the pulmonary circulatory system that occurs in patients of all ages and if untreated, eventually leads to right heart failure and death. Despite existing medical treatment options that improve survival and quality of life, the disease remains incurable. Thus, there is an urgent need to develop novel therapies to treat this disease. Emerging evidence suggests that long non-coding RNAs (lncRNAs) play critical roles in pulmonary vascular remodeling and PAH. LncRNAs are implicated in pulmonary arterial endothelial dysfunction by modulating endothelial cell proliferation, angiogenesis, endothelial mesenchymal transition, and metabolism. LncRNAs are also involved in inducing different pulmonary arterial vascular smooth muscle cell phenotypes, such as cell proliferation, apoptosis, migration, regulation of the phenotypic switching, and cell cycle. LncRNAs are essential regulators of gene expression that affect various diseases at the chromatin, transcriptional, post-translational, and even post-translational levels. Here, we focus on the role of LncRNAs and their molecular mechanisms in the pathogenesis of PAH. We also discuss the current research challenge and potential biomarker and therapeutic potentials of lncRNAs in PAH.
format Online
Article
Text
id pubmed-8394897
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83948972021-08-28 Role of Long Non-Coding RNAs in Pulmonary Arterial Hypertension Han, Yun Ali, Md Khadem Dua, Kamal Spiekerkoetter, Edda Mao, Yuqiang Cells Review Pulmonary arterial hypertension (PAH) is a debilitating condition of the pulmonary circulatory system that occurs in patients of all ages and if untreated, eventually leads to right heart failure and death. Despite existing medical treatment options that improve survival and quality of life, the disease remains incurable. Thus, there is an urgent need to develop novel therapies to treat this disease. Emerging evidence suggests that long non-coding RNAs (lncRNAs) play critical roles in pulmonary vascular remodeling and PAH. LncRNAs are implicated in pulmonary arterial endothelial dysfunction by modulating endothelial cell proliferation, angiogenesis, endothelial mesenchymal transition, and metabolism. LncRNAs are also involved in inducing different pulmonary arterial vascular smooth muscle cell phenotypes, such as cell proliferation, apoptosis, migration, regulation of the phenotypic switching, and cell cycle. LncRNAs are essential regulators of gene expression that affect various diseases at the chromatin, transcriptional, post-translational, and even post-translational levels. Here, we focus on the role of LncRNAs and their molecular mechanisms in the pathogenesis of PAH. We also discuss the current research challenge and potential biomarker and therapeutic potentials of lncRNAs in PAH. MDPI 2021-07-26 /pmc/articles/PMC8394897/ /pubmed/34440661 http://dx.doi.org/10.3390/cells10081892 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Han, Yun
Ali, Md Khadem
Dua, Kamal
Spiekerkoetter, Edda
Mao, Yuqiang
Role of Long Non-Coding RNAs in Pulmonary Arterial Hypertension
title Role of Long Non-Coding RNAs in Pulmonary Arterial Hypertension
title_full Role of Long Non-Coding RNAs in Pulmonary Arterial Hypertension
title_fullStr Role of Long Non-Coding RNAs in Pulmonary Arterial Hypertension
title_full_unstemmed Role of Long Non-Coding RNAs in Pulmonary Arterial Hypertension
title_short Role of Long Non-Coding RNAs in Pulmonary Arterial Hypertension
title_sort role of long non-coding rnas in pulmonary arterial hypertension
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394897/
https://www.ncbi.nlm.nih.gov/pubmed/34440661
http://dx.doi.org/10.3390/cells10081892
work_keys_str_mv AT hanyun roleoflongnoncodingrnasinpulmonaryarterialhypertension
AT alimdkhadem roleoflongnoncodingrnasinpulmonaryarterialhypertension
AT duakamal roleoflongnoncodingrnasinpulmonaryarterialhypertension
AT spiekerkoetteredda roleoflongnoncodingrnasinpulmonaryarterialhypertension
AT maoyuqiang roleoflongnoncodingrnasinpulmonaryarterialhypertension