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Role of Long Non-Coding RNAs in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a debilitating condition of the pulmonary circulatory system that occurs in patients of all ages and if untreated, eventually leads to right heart failure and death. Despite existing medical treatment options that improve survival and quality of life, the dis...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394897/ https://www.ncbi.nlm.nih.gov/pubmed/34440661 http://dx.doi.org/10.3390/cells10081892 |
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author | Han, Yun Ali, Md Khadem Dua, Kamal Spiekerkoetter, Edda Mao, Yuqiang |
author_facet | Han, Yun Ali, Md Khadem Dua, Kamal Spiekerkoetter, Edda Mao, Yuqiang |
author_sort | Han, Yun |
collection | PubMed |
description | Pulmonary arterial hypertension (PAH) is a debilitating condition of the pulmonary circulatory system that occurs in patients of all ages and if untreated, eventually leads to right heart failure and death. Despite existing medical treatment options that improve survival and quality of life, the disease remains incurable. Thus, there is an urgent need to develop novel therapies to treat this disease. Emerging evidence suggests that long non-coding RNAs (lncRNAs) play critical roles in pulmonary vascular remodeling and PAH. LncRNAs are implicated in pulmonary arterial endothelial dysfunction by modulating endothelial cell proliferation, angiogenesis, endothelial mesenchymal transition, and metabolism. LncRNAs are also involved in inducing different pulmonary arterial vascular smooth muscle cell phenotypes, such as cell proliferation, apoptosis, migration, regulation of the phenotypic switching, and cell cycle. LncRNAs are essential regulators of gene expression that affect various diseases at the chromatin, transcriptional, post-translational, and even post-translational levels. Here, we focus on the role of LncRNAs and their molecular mechanisms in the pathogenesis of PAH. We also discuss the current research challenge and potential biomarker and therapeutic potentials of lncRNAs in PAH. |
format | Online Article Text |
id | pubmed-8394897 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83948972021-08-28 Role of Long Non-Coding RNAs in Pulmonary Arterial Hypertension Han, Yun Ali, Md Khadem Dua, Kamal Spiekerkoetter, Edda Mao, Yuqiang Cells Review Pulmonary arterial hypertension (PAH) is a debilitating condition of the pulmonary circulatory system that occurs in patients of all ages and if untreated, eventually leads to right heart failure and death. Despite existing medical treatment options that improve survival and quality of life, the disease remains incurable. Thus, there is an urgent need to develop novel therapies to treat this disease. Emerging evidence suggests that long non-coding RNAs (lncRNAs) play critical roles in pulmonary vascular remodeling and PAH. LncRNAs are implicated in pulmonary arterial endothelial dysfunction by modulating endothelial cell proliferation, angiogenesis, endothelial mesenchymal transition, and metabolism. LncRNAs are also involved in inducing different pulmonary arterial vascular smooth muscle cell phenotypes, such as cell proliferation, apoptosis, migration, regulation of the phenotypic switching, and cell cycle. LncRNAs are essential regulators of gene expression that affect various diseases at the chromatin, transcriptional, post-translational, and even post-translational levels. Here, we focus on the role of LncRNAs and their molecular mechanisms in the pathogenesis of PAH. We also discuss the current research challenge and potential biomarker and therapeutic potentials of lncRNAs in PAH. MDPI 2021-07-26 /pmc/articles/PMC8394897/ /pubmed/34440661 http://dx.doi.org/10.3390/cells10081892 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Han, Yun Ali, Md Khadem Dua, Kamal Spiekerkoetter, Edda Mao, Yuqiang Role of Long Non-Coding RNAs in Pulmonary Arterial Hypertension |
title | Role of Long Non-Coding RNAs in Pulmonary Arterial Hypertension |
title_full | Role of Long Non-Coding RNAs in Pulmonary Arterial Hypertension |
title_fullStr | Role of Long Non-Coding RNAs in Pulmonary Arterial Hypertension |
title_full_unstemmed | Role of Long Non-Coding RNAs in Pulmonary Arterial Hypertension |
title_short | Role of Long Non-Coding RNAs in Pulmonary Arterial Hypertension |
title_sort | role of long non-coding rnas in pulmonary arterial hypertension |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394897/ https://www.ncbi.nlm.nih.gov/pubmed/34440661 http://dx.doi.org/10.3390/cells10081892 |
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