Casein Kinase 1D Encodes a Novel Drug Target in Hedgehog—GLI-Driven Cancers and Tumor-Initiating Cells Resistant to SMO Inhibition

SIMPLE SUMMARY: Uncontrolled activation of hedgehog (HH)—GLI signaling contributes to the development of several human malignancies. Targeted inhibition of the HH—GLI signaling cascade with small-molecule inhibitors can reduce cancer growth, but patient relapse is very common due to the development...

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Detalles Bibliográficos
Autores principales: Peer, Elisabeth, Aichberger, Sophie Karoline, Vilotic, Filip, Gruber, Wolfgang, Parigger, Thomas, Grund-Gröschke, Sandra, Elmer, Dominik Patrick, Rathje, Florian, Ramspacher, Andrea, Zaja, Mirko, Michel, Susanne, Hamm, Svetlana, Aberger, Fritz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394935/
https://www.ncbi.nlm.nih.gov/pubmed/34439381
http://dx.doi.org/10.3390/cancers13164227

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