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Cariogenic Biofilms: Development, Properties, and Biomimetic Preventive Agents

Oral biofilms will build up within minutes after cleaning of the dental hard tissues. While the application of remineralizing agents is a well-known approach to prevent dental caries, modern oral care products offer also additional active agents to maintain oral health. Human saliva contains many di...

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Autores principales: Meyer, Frederic, Enax, Joachim, Epple, Matthias, Amaechi, Bennett T., Simader, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394942/
https://www.ncbi.nlm.nih.gov/pubmed/34436000
http://dx.doi.org/10.3390/dj9080088
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author Meyer, Frederic
Enax, Joachim
Epple, Matthias
Amaechi, Bennett T.
Simader, Barbara
author_facet Meyer, Frederic
Enax, Joachim
Epple, Matthias
Amaechi, Bennett T.
Simader, Barbara
author_sort Meyer, Frederic
collection PubMed
description Oral biofilms will build up within minutes after cleaning of the dental hard tissues. While the application of remineralizing agents is a well-known approach to prevent dental caries, modern oral care products offer also additional active agents to maintain oral health. Human saliva contains many different organic and inorganic compounds that help to buffer organic acids produced by cariogenic microorganisms. However, most oral care products only contain remineralizing agents. To improve the benefit of those products, further active ingredients are needed. Books, review articles, and original research papers were included in this narrative review. Putting all these data together, we give an overview of oral biofilms and active compounds used in modern oral care products to interact with them. The special focus is on inorganic compounds and their interaction with oral biofilms. While organic compounds have several limitations (e.g., cell toxicity), inorganic compounds based on calcium and/or phosphate (e.g., sodium bicarbonate, hydroxyapatite, calcium carbonate) offer several advantages when used in oral care products. Calcium release can inhibit demineralization, and the release of hydroxide and phosphate ions might help in the buffering of acids. Therefore, the focus of this review is to summarize the scientific background of further active ingredients that can be used for oral care formulations.
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spelling pubmed-83949422021-08-28 Cariogenic Biofilms: Development, Properties, and Biomimetic Preventive Agents Meyer, Frederic Enax, Joachim Epple, Matthias Amaechi, Bennett T. Simader, Barbara Dent J (Basel) Review Oral biofilms will build up within minutes after cleaning of the dental hard tissues. While the application of remineralizing agents is a well-known approach to prevent dental caries, modern oral care products offer also additional active agents to maintain oral health. Human saliva contains many different organic and inorganic compounds that help to buffer organic acids produced by cariogenic microorganisms. However, most oral care products only contain remineralizing agents. To improve the benefit of those products, further active ingredients are needed. Books, review articles, and original research papers were included in this narrative review. Putting all these data together, we give an overview of oral biofilms and active compounds used in modern oral care products to interact with them. The special focus is on inorganic compounds and their interaction with oral biofilms. While organic compounds have several limitations (e.g., cell toxicity), inorganic compounds based on calcium and/or phosphate (e.g., sodium bicarbonate, hydroxyapatite, calcium carbonate) offer several advantages when used in oral care products. Calcium release can inhibit demineralization, and the release of hydroxide and phosphate ions might help in the buffering of acids. Therefore, the focus of this review is to summarize the scientific background of further active ingredients that can be used for oral care formulations. MDPI 2021-08-03 /pmc/articles/PMC8394942/ /pubmed/34436000 http://dx.doi.org/10.3390/dj9080088 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Meyer, Frederic
Enax, Joachim
Epple, Matthias
Amaechi, Bennett T.
Simader, Barbara
Cariogenic Biofilms: Development, Properties, and Biomimetic Preventive Agents
title Cariogenic Biofilms: Development, Properties, and Biomimetic Preventive Agents
title_full Cariogenic Biofilms: Development, Properties, and Biomimetic Preventive Agents
title_fullStr Cariogenic Biofilms: Development, Properties, and Biomimetic Preventive Agents
title_full_unstemmed Cariogenic Biofilms: Development, Properties, and Biomimetic Preventive Agents
title_short Cariogenic Biofilms: Development, Properties, and Biomimetic Preventive Agents
title_sort cariogenic biofilms: development, properties, and biomimetic preventive agents
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394942/
https://www.ncbi.nlm.nih.gov/pubmed/34436000
http://dx.doi.org/10.3390/dj9080088
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