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Flecainide Paradoxically Activates Cardiac Ryanodine Receptor Channels under Low Activity Conditions: A Potential Pro-Arrhythmic Action

Cardiac ryanodine receptor (RyR2) mutations are implicated in the potentially fatal catecholaminergic polymorphic ventricular tachycardia (CPVT) and in atrial fibrillation. CPVT has been successfully treated with flecainide monotherapy, with occasional notable exceptions. Reported actions of flecain...

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Detalles Bibliográficos
Autores principales:	Salvage, Samantha C., Gallant, Esther M., Fraser, James A., Huang, Christopher L.-H., Dulhunty, Angela F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394964/ https://www.ncbi.nlm.nih.gov/pubmed/34440870 http://dx.doi.org/10.3390/cells10082101

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