Therapeutic Strategies for Mutant SPAST-Based Hereditary Spastic Paraplegia

Mutations of the SPAST gene that encodes the microtubule-severing enzyme called spastin are the chief cause of Hereditary Spastic Paraplegia. Growing evidence indicates that pathogenic mutations functionally compromise the spastin protein and endow it with toxic gain-of-function properties. With eac...

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Detalles Bibliográficos
Autores principales: Mohan, Neha, Qiang, Liang, Morfini, Gerardo, Baas, Peter W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394973/
https://www.ncbi.nlm.nih.gov/pubmed/34439700
http://dx.doi.org/10.3390/brainsci11081081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394973/
https://www.ncbi.nlm.nih.gov/pubmed/34439700
http://dx.doi.org/10.3390/brainsci11081081

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