Cargando…

CDK4, CDK6/cyclin-D1 Complex Inhibition and Radiotherapy for Cancer Control: A Role for Autophagy

The expanding clinical application of CDK4- and CDK6-inhibiting drugs in the managements of breast cancer has raised a great interest in testing these drugs in other neoplasms. The potential of combining these drugs with other therapeutic approaches seems to be an interesting work-ground to explore....

Descripción completa

Detalles Bibliográficos
Autores principales:	Nardone, Valerio, Barbarino, Marcella, Angrisani, Antonio, Correale, Pierpaolo, Pastina, Pierpaolo, Cappabianca, Salvatore, Reginelli, Alfonso, Mutti, Luciano, Miracco, Clelia, Giannicola, Rocco, Giordano, Antonio, Pirtoli, Luigi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395054/ https://www.ncbi.nlm.nih.gov/pubmed/34445095 http://dx.doi.org/10.3390/ijms22168391

Ejemplares similares

The role of brain radiotherapy for EGFR- and ALK-positive non-small-cell lung cancer with brain metastases: a review
por: Nardone, Valerio, et al.
Publicado: (2023)

How to Increase the Efficacy of Immunotherapy in NSCLC and HNSCC: Role of Radiation Therapy, Chemotherapy, and Other Strategies
por: Nardone, Valerio, et al.
Publicado: (2018)

Inflammatory Markers and Procalcitonin Predict the Outcome of Metastatic Non-Small-Cell-Lung-Cancer Patients Receiving PD-1/PD-L1 Immune-Checkpoint Blockade
por: Nardone, Valerio, et al.
Publicado: (2021)

Patients Affected by Unmethylated O(6)-Methylguanine-DNA Methyltransferase Glioblastoma Undergoing Radiochemotherapy May Benefit from Moderately Dose-Escalated Radiotherapy
por: Tini, Paolo, et al.
Publicado: (2017)

Distinctive Role of the Systemic Inflammatory Profile in Non-Small-Cell Lung Cancer Younger and Elderly Patients Treated with a PD-1 Immune Checkpoint Blockade: A Real-World Retrospective Multi-Institutional Analysis
por: Nardone, Valerio, et al.
Publicado: (2021)

Magnetic-Resonance-Imaging Texture Analysis Predicts Early Progression in Rectal Cancer Patients Undergoing Neoadjuvant Chemoradiation
por: Nardone, Valerio, et al.
Publicado: (2019)

Combined Epidermal Growth Factor Receptor and Beclin1 Autophagic Protein Expression Analysis Identifies Different Clinical Presentations, Responses to Chemo- and Radiotherapy, and Prognosis in Glioblastoma
por: Tini, Paolo, et al.
Publicado: (2015)

On the way of the new strategies aimed to improve the efficacy of PD-1/PD-L1 immune checkpoint blocking mAbs in small cell lung cancer
por: Correale, Pierpaolo, et al.
Publicado: (2020)

Ability of Delta Radiomics to Predict a Complete Pathological Response in Patients with Loco-Regional Rectal Cancer Addressed to Neoadjuvant Chemo-Radiation and Surgery
por: Nardone, Valerio, et al.
Publicado: (2022)

Systemic inflammatory status predict the outcome of k-RAS WT metastatic colorectal cancer patients receiving the thymidylate synthase poly-epitope-peptide anticancer vaccine
por: Correale, Pierpaolo, et al.
Publicado: (2018)

HLA Expression Correlates to the Risk of Immune Checkpoint Inhibitor-Induced Pneumonitis
por: Correale, Pierpaolo, et al.
Publicado: (2020)

Analysis of new treatments proposed for malignant pleural mesothelioma raises concerns about the conduction of clinical trials in oncology
por: Meirson, Tomer, et al.
Publicado: (2022)

Radiotherapy prolongs the survival of advanced non-small-cell lung cancer patients undergone to an immune-modulating treatment with dose-fractioned cisplatin and metronomic etoposide and bevacizumab (mPEBev)
por: Pastina, Pierpaolo, et al.
Publicado: (2017)

Cyclin K goes with Cdk12 and Cdk13
por: Kohoutek, Jiri, et al.
Publicado: (2012)

GOLFIG Chemo-Immunotherapy in Metastatic Colorectal Cancer Patients. A Critical Review on a Long-Lasting Follow-Up
por: Caraglia, Michele, et al.
Publicado: (2019)

Molecular docking analysis of piperine with CDK2,CDK4,Cyclin D and Cyclin T proteins
por: Rekha, Umapathy Vidhya, et al.
Publicado: (2020)

HLA-B*44 and C*01 Prevalence Correlates with Covid19 Spreading across Italy
por: Correale, Pierpaolo, et al.
Publicado: (2020)

Mood Disorder in Cancer Patients Undergoing Radiotherapy During the COVID-19 Outbreak
por: Nardone, Valerio, et al.
Publicado: (2021)

Inflammatory status affects the antitumor activity of poly-epitope-peptide vaccination against the thymidylate synthase in metastatic colo-rectal cancer patients enrolled in TSPP/VAC-1 Phase Ib trial
por: Correale, Pierpaolo, et al.
Publicado: (2015)

PD-1/PD-L1 immune-checkpoint blockade induces immune effector cell modulation in metastatic non-small cell lung cancer patients: A single-cell flow cytometry approach
por: Fameli, Antonella, et al.
Publicado: (2022)

Distinctive germline expression of class I human leukocyte antigen (HLA) alleles and DRB1 heterozygosis predict the outcome of patients with non-small cell lung cancer receiving PD-1/PD-L1 immune checkpoint blockade
por: Correale, Pierpaolo, et al.
Publicado: (2020)

Cell cycle progression mechanisms: slower cyclin-D/CDK4 activation and faster cyclin-E/CDK2
por: Zhang, Wengang, et al.
Publicado: (2023)

Nuclear Import of Cdk/Cyclin Complexes: Identification of Distinct Mechanisms for Import of Cdk2/Cyclin E and Cdc2/Cyclin B1
por: Moore, Jonathan D., et al.
Publicado: (1999)

Lineage specific composition of cyclin D–CDK4/CDK6–p27 complexes reveals distinct functions of CDK4, CDK6 and individual D‐type cyclins in differentiating cells of embryonic origin
por: Bryja, V., et al.
Publicado: (2008)

Cyclin B/CDK1 and Cyclin A/CDK2 phosphorylate DENR to promote mitotic protein translation and faithful cell division
por: Clemm von Hohenberg, Katharina, et al.
Publicado: (2022)

Coronavirus Disease (Covid-19): What Are We Learning in a Country With High Mortality Rate?
por: Mutti, Luciano, et al.
Publicado: (2020)

Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells
por: Zhang, Jiawei, et al.
Publicado: (2022)

Phylogenetic analysis of CDK and cyclin proteins in premetazoan lineages
por: Cao, Lihuan, et al.
Publicado: (2014)

Structural insights into the functional diversity of the CDK–cyclin family
por: Wood, Daniel J., et al.
Publicado: (2018)

The awakening of the CDK10/Cyclin M protein kinase
por: Guen, Vincent J., et al.
Publicado: (2017)

The CDK Subunit CKS2 Counteracts CKS1 to Control Cyclin A/CDK2 Activity in Maintaining Replicative Fidelity and Neurodevelopment
por: Frontini, Mattia, et al.
Publicado: (2012)

Comparison of deregulated expression of cyclin D1 and cyclin E with that of cyclin-dependent kinase 4 (CDK4) and CDK2 in human oesophageal squamous cell carcinoma
por: Matsumoto, M, et al.
Publicado: (1999)

Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2
por: Pack, Lindsey R., et al.
Publicado: (2021)

Temporal changes in cyclinD-CDK4/CDK6 and cyclinE-CDK2 pathways: implications for the mechanism of deficient decidualization in an immune-based mouse model of unexplained recurrent spontaneous abortion
por: Chang, Zhuo, et al.
Publicado: (2022)

Is There Already a Need of Reckoning on Cancer Immunotherapy?
por: Correale, Pierpaolo, et al.
Publicado: (2021)

Chemoradiotherapy for Head and Neck Cancer
por: D’Onofrio, Ida, et al.
Publicado: (2023)

Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells
por: Kang, Jian, et al.
Publicado: (2014)

The Cyclin-dependent Kinase Cdk2 Regulates Thymocyte Apoptosis
por: Hakem, Anne, et al.
Publicado: (1999)

Rising Cyclin-CDK Levels Order Cell Cycle Events
por: Oikonomou, Catherine, et al.
Publicado: (2011)

The structure and substrate specificity of human Cdk12/Cyclin K
por: Bösken, Christian A., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_vg9mu2151803n07mie8rvrvgjl