The Influence of Microbiome Dysbiosis and Bacterial Biofilms on Epidermal Barrier Function in Atopic Dermatitis—An Update

Atopic dermatitis (AD) is a common inflammatory dermatosis affecting up to 30% of children and 10% of adults worldwide. AD is primarily driven by an epidermal barrier defect which triggers immune dysregulation within the skin. According to recent research such phenomena are closely related to the mi...

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Autores principales: Blicharz, Leszek, Rudnicka, Lidia, Czuwara, Joanna, Waśkiel-Burnat, Anna, Goldust, Mohamad, Olszewska, Małgorzata, Samochocki, Zbigniew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395079/
https://www.ncbi.nlm.nih.gov/pubmed/34445108
http://dx.doi.org/10.3390/ijms22168403
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author Blicharz, Leszek
Rudnicka, Lidia
Czuwara, Joanna
Waśkiel-Burnat, Anna
Goldust, Mohamad
Olszewska, Małgorzata
Samochocki, Zbigniew
author_facet Blicharz, Leszek
Rudnicka, Lidia
Czuwara, Joanna
Waśkiel-Burnat, Anna
Goldust, Mohamad
Olszewska, Małgorzata
Samochocki, Zbigniew
author_sort Blicharz, Leszek
collection PubMed
description Atopic dermatitis (AD) is a common inflammatory dermatosis affecting up to 30% of children and 10% of adults worldwide. AD is primarily driven by an epidermal barrier defect which triggers immune dysregulation within the skin. According to recent research such phenomena are closely related to the microbial dysbiosis of the skin. There is growing evidence that cutaneous microbiota and bacterial biofilms negatively affect skin barrier function, contributing to the onset and exacerbation of AD. This review summarizes the latest data on the mechanisms leading to microbiome dysbiosis and biofilm formation in AD, and the influence of these phenomena on skin barrier function.
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spelling pubmed-83950792021-08-28 The Influence of Microbiome Dysbiosis and Bacterial Biofilms on Epidermal Barrier Function in Atopic Dermatitis—An Update Blicharz, Leszek Rudnicka, Lidia Czuwara, Joanna Waśkiel-Burnat, Anna Goldust, Mohamad Olszewska, Małgorzata Samochocki, Zbigniew Int J Mol Sci Review Atopic dermatitis (AD) is a common inflammatory dermatosis affecting up to 30% of children and 10% of adults worldwide. AD is primarily driven by an epidermal barrier defect which triggers immune dysregulation within the skin. According to recent research such phenomena are closely related to the microbial dysbiosis of the skin. There is growing evidence that cutaneous microbiota and bacterial biofilms negatively affect skin barrier function, contributing to the onset and exacerbation of AD. This review summarizes the latest data on the mechanisms leading to microbiome dysbiosis and biofilm formation in AD, and the influence of these phenomena on skin barrier function. MDPI 2021-08-05 /pmc/articles/PMC8395079/ /pubmed/34445108 http://dx.doi.org/10.3390/ijms22168403 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Blicharz, Leszek
Rudnicka, Lidia
Czuwara, Joanna
Waśkiel-Burnat, Anna
Goldust, Mohamad
Olszewska, Małgorzata
Samochocki, Zbigniew
The Influence of Microbiome Dysbiosis and Bacterial Biofilms on Epidermal Barrier Function in Atopic Dermatitis—An Update
title The Influence of Microbiome Dysbiosis and Bacterial Biofilms on Epidermal Barrier Function in Atopic Dermatitis—An Update
title_full The Influence of Microbiome Dysbiosis and Bacterial Biofilms on Epidermal Barrier Function in Atopic Dermatitis—An Update
title_fullStr The Influence of Microbiome Dysbiosis and Bacterial Biofilms on Epidermal Barrier Function in Atopic Dermatitis—An Update
title_full_unstemmed The Influence of Microbiome Dysbiosis and Bacterial Biofilms on Epidermal Barrier Function in Atopic Dermatitis—An Update
title_short The Influence of Microbiome Dysbiosis and Bacterial Biofilms on Epidermal Barrier Function in Atopic Dermatitis—An Update
title_sort influence of microbiome dysbiosis and bacterial biofilms on epidermal barrier function in atopic dermatitis—an update
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395079/
https://www.ncbi.nlm.nih.gov/pubmed/34445108
http://dx.doi.org/10.3390/ijms22168403
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