WNT Signaling as a Therapeutic Target for Glioblastoma

The WNT (Wingless/Integrated) signaling pathway is implicated in various stages of glioblastoma, which is an aggressive brain tumor for which therapeutic options are limited. WNT has been recognized as a hallmark of therapeutic challenge due to its context-dependent role and critical function in hea...

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Detalles Bibliográficos
Autores principales: Latour, Michael, Her, Nam-Gu, Kesari, Santosh, Nurmemmedov, Elmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395085/
https://www.ncbi.nlm.nih.gov/pubmed/34445128
http://dx.doi.org/10.3390/ijms22168428
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author Latour, Michael
Her, Nam-Gu
Kesari, Santosh
Nurmemmedov, Elmar
author_facet Latour, Michael
Her, Nam-Gu
Kesari, Santosh
Nurmemmedov, Elmar
author_sort Latour, Michael
collection PubMed
description The WNT (Wingless/Integrated) signaling pathway is implicated in various stages of glioblastoma, which is an aggressive brain tumor for which therapeutic options are limited. WNT has been recognized as a hallmark of therapeutic challenge due to its context-dependent role and critical function in healthy tissue homeostasis. In this review, we deeply scrutinize the WNT signaling pathway and its involvement in the genesis of glioblastoma as well as its acquired therapy resistance. We also provide an analysis of the WNT pathway in terms of its therapeutic importance in addition to an overview of the current targeted therapies under clinical investigation.
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spelling pubmed-83950852021-08-28 WNT Signaling as a Therapeutic Target for Glioblastoma Latour, Michael Her, Nam-Gu Kesari, Santosh Nurmemmedov, Elmar Int J Mol Sci Review The WNT (Wingless/Integrated) signaling pathway is implicated in various stages of glioblastoma, which is an aggressive brain tumor for which therapeutic options are limited. WNT has been recognized as a hallmark of therapeutic challenge due to its context-dependent role and critical function in healthy tissue homeostasis. In this review, we deeply scrutinize the WNT signaling pathway and its involvement in the genesis of glioblastoma as well as its acquired therapy resistance. We also provide an analysis of the WNT pathway in terms of its therapeutic importance in addition to an overview of the current targeted therapies under clinical investigation. MDPI 2021-08-05 /pmc/articles/PMC8395085/ /pubmed/34445128 http://dx.doi.org/10.3390/ijms22168428 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Latour, Michael
Her, Nam-Gu
Kesari, Santosh
Nurmemmedov, Elmar
WNT Signaling as a Therapeutic Target for Glioblastoma
title WNT Signaling as a Therapeutic Target for Glioblastoma
title_full WNT Signaling as a Therapeutic Target for Glioblastoma
title_fullStr WNT Signaling as a Therapeutic Target for Glioblastoma
title_full_unstemmed WNT Signaling as a Therapeutic Target for Glioblastoma
title_short WNT Signaling as a Therapeutic Target for Glioblastoma
title_sort wnt signaling as a therapeutic target for glioblastoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395085/
https://www.ncbi.nlm.nih.gov/pubmed/34445128
http://dx.doi.org/10.3390/ijms22168428
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AT hernamgu wntsignalingasatherapeutictargetforglioblastoma
AT kesarisantosh wntsignalingasatherapeutictargetforglioblastoma
AT nurmemmedovelmar wntsignalingasatherapeutictargetforglioblastoma

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