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Therapeutic Potential of Jasmonic Acid and Its Derivatives

A modern method of therapeutic use of natural compounds that would protect the body are jasmonates. The main representatives of jasmonate compounds include jasmonic acid and its derivatives, mainly methyl jasmonate. Extracts from plants rich in jasmonic compounds show a broad spectrum of activity, i...

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Autores principales: Jarocka-Karpowicz, Iwona, Markowska, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395089/
https://www.ncbi.nlm.nih.gov/pubmed/34445138
http://dx.doi.org/10.3390/ijms22168437
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author Jarocka-Karpowicz, Iwona
Markowska, Agnieszka
author_facet Jarocka-Karpowicz, Iwona
Markowska, Agnieszka
author_sort Jarocka-Karpowicz, Iwona
collection PubMed
description A modern method of therapeutic use of natural compounds that would protect the body are jasmonates. The main representatives of jasmonate compounds include jasmonic acid and its derivatives, mainly methyl jasmonate. Extracts from plants rich in jasmonic compounds show a broad spectrum of activity, i.e., anti-cancer, anti-inflammatory and cosmetic. Studies of the biological activity of jasmonic acid and its derivatives in mammals are based on their structural similarity to prostaglandins and the compounds can be used as natural therapeutics for inflammation. Jasmonates also constitute a potential group of anti-cancer drugs that can be used alone or in combination with other known chemotherapeutic agents. Moreover, due to their ability to stimulate exfoliation of the epidermis, remove discoloration, regulate the function of the sebaceous glands and reduce the visible signs of aging, they are considered for possible use in cosmetics and dermatology. The paper presents a review of literature data on the biological activity of jasmonates that may be helpful in treatment and prevention.
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spelling pubmed-83950892021-08-28 Therapeutic Potential of Jasmonic Acid and Its Derivatives Jarocka-Karpowicz, Iwona Markowska, Agnieszka Int J Mol Sci Review A modern method of therapeutic use of natural compounds that would protect the body are jasmonates. The main representatives of jasmonate compounds include jasmonic acid and its derivatives, mainly methyl jasmonate. Extracts from plants rich in jasmonic compounds show a broad spectrum of activity, i.e., anti-cancer, anti-inflammatory and cosmetic. Studies of the biological activity of jasmonic acid and its derivatives in mammals are based on their structural similarity to prostaglandins and the compounds can be used as natural therapeutics for inflammation. Jasmonates also constitute a potential group of anti-cancer drugs that can be used alone or in combination with other known chemotherapeutic agents. Moreover, due to their ability to stimulate exfoliation of the epidermis, remove discoloration, regulate the function of the sebaceous glands and reduce the visible signs of aging, they are considered for possible use in cosmetics and dermatology. The paper presents a review of literature data on the biological activity of jasmonates that may be helpful in treatment and prevention. MDPI 2021-08-05 /pmc/articles/PMC8395089/ /pubmed/34445138 http://dx.doi.org/10.3390/ijms22168437 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jarocka-Karpowicz, Iwona
Markowska, Agnieszka
Therapeutic Potential of Jasmonic Acid and Its Derivatives
title Therapeutic Potential of Jasmonic Acid and Its Derivatives
title_full Therapeutic Potential of Jasmonic Acid and Its Derivatives
title_fullStr Therapeutic Potential of Jasmonic Acid and Its Derivatives
title_full_unstemmed Therapeutic Potential of Jasmonic Acid and Its Derivatives
title_short Therapeutic Potential of Jasmonic Acid and Its Derivatives
title_sort therapeutic potential of jasmonic acid and its derivatives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395089/
https://www.ncbi.nlm.nih.gov/pubmed/34445138
http://dx.doi.org/10.3390/ijms22168437
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