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Anticancer Activity and Mechanisms of Action of New Chimeric EGFR/HDAC-Inhibitors

New chimeric inhibitors targeting the epidermal growth factor (EGFR) and histone deacetylases (HDACs) were synthesized and tested for antineoplastic efficiency in solid cancer (prostate and hepatocellular carcinoma) and leukemia/lymphoma cell models. The most promising compounds, 3BrQuin-SAHA and 3C...

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Detalles Bibliográficos
Autores principales:	Goehringer, Nils, Biersack, Bernhard, Peng, Yayi, Schobert, Rainer, Herling, Marco, Ma, Andi, Nitzsche, Bianca, Höpfner, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395095/ https://www.ncbi.nlm.nih.gov/pubmed/34445133 http://dx.doi.org/10.3390/ijms22168432

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