Immunonano-Lipocarrier-Mediated Liver Sinusoidal Endothelial Cell-Specific RUNX1 Inhibition Impedes Immune Cell Infiltration and Hepatic Inflammation in Murine Model of NASH

Background: Runt-related transcription factor (RUNX1) regulates inflammation in non-alcoholic steatohepatitis (NASH). Methods: We performed in vivo targeted silencing of the RUNX1 gene in liver sinusoidal endothelial cells (LSECs) by using vegfr3 antibody tagged immunonano-lipocarriers encapsulated...

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Detalles Bibliográficos
Autores principales: Tripathi, Dinesh Mani, Rohilla, Sumati, Kaur, Impreet, Siddiqui, Hamda, Rawal, Preety, Juneja, Pinky, Kumar, Vikash, Kumari, Anupama, Naidu, Vegi Ganga Modi, Ramakrishna, Seeram, Banerjee, Subham, Puria, Rekha, Sarin, Shiv K., Kaur, Savneet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395158/
https://www.ncbi.nlm.nih.gov/pubmed/34445195
http://dx.doi.org/10.3390/ijms22168489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395158/
https://www.ncbi.nlm.nih.gov/pubmed/34445195
http://dx.doi.org/10.3390/ijms22168489

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