Cargando…

Immunonano-Lipocarrier-Mediated Liver Sinusoidal Endothelial Cell-Specific RUNX1 Inhibition Impedes Immune Cell Infiltration and Hepatic Inflammation in Murine Model of NASH

Background: Runt-related transcription factor (RUNX1) regulates inflammation in non-alcoholic steatohepatitis (NASH). Methods: We performed in vivo targeted silencing of the RUNX1 gene in liver sinusoidal endothelial cells (LSECs) by using vegfr3 antibody tagged immunonano-lipocarriers encapsulated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tripathi, Dinesh Mani, Rohilla, Sumati, Kaur, Impreet, Siddiqui, Hamda, Rawal, Preety, Juneja, Pinky, Kumar, Vikash, Kumari, Anupama, Naidu, Vegi Ganga Modi, Ramakrishna, Seeram, Banerjee, Subham, Puria, Rekha, Sarin, Shiv K., Kaur, Savneet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395158/ https://www.ncbi.nlm.nih.gov/pubmed/34445195 http://dx.doi.org/10.3390/ijms22168489

Ejemplares similares

Recombinant VEGF-C (Cys156Ser) improves mesenteric lymphatic drainage and gut immune surveillance in experimental cirrhosis
por: Juneja, Pinky, et al.
Publicado: (2023)

Increased Expression of RUNX1 in Liver Correlates with NASH Activity Score in Patients with Non-Alcoholic Steatohepatitis (NASH)
por: Kaur, Savneet, et al.
Publicado: (2019)

Primary Hepatocyte Isolation and Cultures: Technical Aspects, Challenges and Advancements
por: Kaur, Impreet, et al.
Publicado: (2023)

Cirrhotic Endothelial Progenitor Cells Enhance Liver Angiogenesis and Fibrosis and Aggravate Portal Hypertension in Bile Duct-Ligated Cirrhotic Rats
por: Tripathi, Dinesh Mani, et al.
Publicado: (2020)

VEGF-mediated tumour growth and EMT in 2D and 3D cell culture models of hepatocellular carcinoma
por: Rawal, Preety, et al.
Publicado: (2022)

Endothelial Cell-Derived TGF-β Promotes Epithelial-Mesenchymal Transition via CD133 in HBx-Infected Hepatoma Cells
por: Rawal, Preety, et al.
Publicado: (2019)

Podoplanin-positive dilated lymphatic vessels in duodenum associates with three-month mortality in patients with cirrhosis
por: Juneja, Pinky, et al.
Publicado: (2023)

Conformationally Restricted Dipeptide-Based Nanoparticles for Delivery of siRNA in Experimental Liver Cirrhosis
por: Biswas, Saikat, et al.
Publicado: (2022)

Synergic effect of atorvastatin and ambrisentan on sinusoidal and hemodynamic alterations in a rat model of NASH
por: Bravo, Miren, et al.
Publicado: (2021)

Restoration of liver sinusoidal cell phenotypes by statins improves portal hypertension and histology in rats with NASH
por: Bravo, Miren, et al.
Publicado: (2019)

The Crosstalk Between Liver Sinusoidal Endothelial Cells and Hepatic Microenvironment in NASH Related Liver Fibrosis
por: Du, Wei, et al.
Publicado: (2022)

Polymeric Core–Shell Combinatorial Nanomedicine for Synergistic Anticancer Therapy
por: Shanavas, Asifkhan, et al.
Publicado: (2019)

Evolution of Electrospinning in Liver Tissue Engineering
por: Vasudevan, Ashwini, et al.
Publicado: (2022)

A New Potential Strategy for Acute Non-Alcoholic Steatohepatitis (NASH)
por: Sekhon, Anupamjeet Kaur, et al.
Publicado: (2021)

The Enigma of Endothelium in COVID-19
por: Kaur, Savneet, et al.
Publicado: (2020)

Mediation of Sinusoidal Network Oscillations in the Locus Coeruleus of Newborn Rat Slices by Pharmacologically Distinct AMPA and KA Receptors
por: Rawal, Bijal, et al.
Publicado: (2022)

Cell Autophagy in NASH and NASH-Related Hepatocellular Carcinoma
por: Udoh, Utibe-Abasi S., et al.
Publicado: (2022)

Nash vek /
por: Nappelʹbaum, Moisei Solomonovich, 1869-1958
Publicado: (1984)

Nash manifolds
por: Shiota, Masahiro
Publicado: (1987)

Modeling NASH and NASH-Induced Hepatocellular Carcinoma: Faster and Better
por: Hirsova, Petra
Publicado: (2021)

Development of the Rabbit NASH Model Resembling Human NASH and Atherosclerosis
por: Hayashi, Momoko, et al.
Publicado: (2023)

Diabetic Striatopathy: A New Challenge in Type 1 Pediatric Diabetic Patients
por: Rai, Seema, et al.
Publicado: (2022)

From NASH to diabetes and from diabetes to NASH: Mechanisms and treatment options
por: Gastaldelli, Amalia, et al.
Publicado: (2019)

The essential John Nash
por: Nash, John, et al.
Publicado: (2002)

Molecular Pathogenesis of NASH
por: Caligiuri, Alessandra, et al.
Publicado: (2016)

Natural history of NASH
por: Armandi, Angelo, et al.
Publicado: (2021)

Arachidonic and eicosapentaenoic acids induce oxidative stress to suppress proliferation of human glioma cells
por: Hari, Anasuya Devi, et al.
Publicado: (2020)

Sinusoids: theory and technological applications
por: Kythe, Prem K
Publicado: (2014)

The Hepatic Sinusoid in Aging and Disease: Update and Advances From the 20th Liver Sinusoid Meeting
por: Ortega‐Ribera, Martí, et al.
Publicado: (2020)

Develop on Yammer: social integration for modern business applications
por: Rawal, Pathik, et al.
Publicado: (2015)

A Novel Animal Model of Nonalcoholic Steatohepatitis (NASH): Hypoxemia Enhances the Development of NASH
por: Takayama, Fusako, et al.
Publicado: (2009)

The Emerging Role of Extracellular Vesicles and Autophagy Machinery in NASH—Future Horizons in NASH Management
por: Trifylli, Eleni-Myrto, et al.
Publicado: (2022)

Utilizing the ASTHMAXcel PRO Mobile Platform to Conduct a Virtual Cohort Study During the COVID-19 Pandemic
por: Cosar, Emine, et al.
Publicado: (2021)

Circulating Endothelial Progenitor Cells Present an Inflammatory Phenotype and Function in Patients With Alcoholic Liver Cirrhosis
por: Kaur, Savneet, et al.
Publicado: (2018)

Comment on: The Difference in Expression of Autophagy-Related Proteins in Lesional and Perilesional Skin in Adult Patients with Active and Stable Generalized Vitiligo—A Cross-Sectional Pilot Study
por: Grover, Parneet Kaur, et al.
Publicado: (2022)

Comment on: Metabolic Status, Obesity, and Quality of Life in Patients with Acne Vulgaris: A Cross-Sectional Case-Control Study
por: Rohilla, Ravi, et al.
Publicado: (2023)

Stability and perfection of nash equilibria
por: Damme, Eric
Publicado: (1991)

Immune and inflammatory pathways in NASH
por: Ganz, Michal, et al.
Publicado: (2013)

Natural History of NAFLD/NASH
por: Ekstedt, Mattias, et al.
Publicado: (2017)

Dr. Thomas Nash Reed
Publicado: (1870)

Cannot write session to /tmp/vufind_sessions/sess_tqpiirl37k8vi3h9j5ssai68hu