Cargando…
Mitochondrial Metabolism behind Region-Specific Resistance to Ischemia-Reperfusion Injury in Gerbil Hippocampus. Role of PKCβII and Phosphate-Activated Glutaminase
Ischemic episodes are a leading cause of death worldwide with limited therapeutic interventions. The current study explored mitochondrial phosphate-activated glutaminase (GLS1) activity modulation by PKCβII through GC-MS untargeted metabolomics approach. Mitochondria were used to elucidate the endog...
Autores principales: | Beręsewicz-Haller, Małgorzata, Krupska, Olga, Bochomulski, Paweł, Dudzik, Danuta, Chęcińska, Anita, Hilgier, Wojciech, Barbas, Coral, Zablocki, Krzysztof, Zablocka, Barbara |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395184/ https://www.ncbi.nlm.nih.gov/pubmed/34445210 http://dx.doi.org/10.3390/ijms22168504 |
Ejemplares similares
-
Ischemia/Reperfusion-Induced Translocation of PKCβII to Mitochondria as an Important Mediator of a Protective Signaling Mechanism in an Ischemia-Resistant Region of the Hippocampus
por: Krupska, Olga, et al.
Publicado: (2017) -
Hippocampal Sector–Specific Metabolic Profiles Reflect Endogenous Strategy for Ischemia-Reperfusion Insult Resistance
por: Krupska, Olga, et al.
Publicado: (2020) -
Validation of the Reference Genes for Expression Analysis in the Hippocampus after Transient Ischemia/Reperfusion Injury in Gerbil Brain
por: Lewczuk, Anita, et al.
Publicado: (2023) -
Is Nrf2 Behind Endogenous Neuroprotection of the Hippocampal CA2-4,DG Region?
por: Lewczuk, Anita, et al.
Publicado: (2022) -
Phosphorylation of glutaminase by PKCε is essential for its enzymatic activity and critically contributes to tumorigenesis
por: Han, Tianyu, et al.
Publicado: (2018)