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High Power Electromagnetic Waves Exposure of Healthy and Tumor Bearing Mice: Assessment of Effects on Mice Growth, Behavior, Tumor Growth, and Vessel Permeabilization

High power radiofrequencies may transiently or permanently disrupt the functioning of electronic devices, but their effect on living systems remains unknown. With the aim to evaluate the safety and biological effects of narrow-band and wide-band high-power electromagnetic (HPEM) waves, we studied th...

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Autores principales: Kolosnjaj-Tabi, Jelena, Golzio, Muriel, Bellard, Elisabeth, Catrain, Alexandre, Chretiennot, Thomas, Saurin, Quentin, Tarayre, Jacques, Vezinet, René, Rols, Marie-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395230/
https://www.ncbi.nlm.nih.gov/pubmed/34445226
http://dx.doi.org/10.3390/ijms22168516
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author Kolosnjaj-Tabi, Jelena
Golzio, Muriel
Bellard, Elisabeth
Catrain, Alexandre
Chretiennot, Thomas
Saurin, Quentin
Tarayre, Jacques
Vezinet, René
Rols, Marie-Pierre
author_facet Kolosnjaj-Tabi, Jelena
Golzio, Muriel
Bellard, Elisabeth
Catrain, Alexandre
Chretiennot, Thomas
Saurin, Quentin
Tarayre, Jacques
Vezinet, René
Rols, Marie-Pierre
author_sort Kolosnjaj-Tabi, Jelena
collection PubMed
description High power radiofrequencies may transiently or permanently disrupt the functioning of electronic devices, but their effect on living systems remains unknown. With the aim to evaluate the safety and biological effects of narrow-band and wide-band high-power electromagnetic (HPEM) waves, we studied their effects upon exposure of healthy and tumor-bearing mice. In field experiments, the exposure to 1.5 GHz narrow-band electromagnetic fields with the incident amplitude peak value level in the range of 40 kV/m and 150 MHz wide-band electric fields with the amplitude peak value in the range of 200 kV/m, did not alter healthy and tumor-bearing animals’ growth, nor it had any impact on cutaneous murine tumors’ growth. While we did not observe any noticeable behavioral changes in mice during the exposure to narrow-band signals when wide-band HPEM signals were applied, mice could behave in a similar way as they respond to loud noise signals: namely, if a mouse was exploring the cage prior to signal application, it returned to companion mates when wide-band HPEM signals were applied. Moreover, the effect of wide-band signals was assessed on normal blood vessels permeability in real-time in dorsal-chamber-bearing mice exposed in a pilot study using wide-band signal applicators. Our pilot study conducted within the applicator and performed at the laboratory scale suggests that the exposure to wide-band signals with the amplitude of 47.5 kV/m does not result in increased vessel permeability.
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spelling pubmed-83952302021-08-28 High Power Electromagnetic Waves Exposure of Healthy and Tumor Bearing Mice: Assessment of Effects on Mice Growth, Behavior, Tumor Growth, and Vessel Permeabilization Kolosnjaj-Tabi, Jelena Golzio, Muriel Bellard, Elisabeth Catrain, Alexandre Chretiennot, Thomas Saurin, Quentin Tarayre, Jacques Vezinet, René Rols, Marie-Pierre Int J Mol Sci Article High power radiofrequencies may transiently or permanently disrupt the functioning of electronic devices, but their effect on living systems remains unknown. With the aim to evaluate the safety and biological effects of narrow-band and wide-band high-power electromagnetic (HPEM) waves, we studied their effects upon exposure of healthy and tumor-bearing mice. In field experiments, the exposure to 1.5 GHz narrow-band electromagnetic fields with the incident amplitude peak value level in the range of 40 kV/m and 150 MHz wide-band electric fields with the amplitude peak value in the range of 200 kV/m, did not alter healthy and tumor-bearing animals’ growth, nor it had any impact on cutaneous murine tumors’ growth. While we did not observe any noticeable behavioral changes in mice during the exposure to narrow-band signals when wide-band HPEM signals were applied, mice could behave in a similar way as they respond to loud noise signals: namely, if a mouse was exploring the cage prior to signal application, it returned to companion mates when wide-band HPEM signals were applied. Moreover, the effect of wide-band signals was assessed on normal blood vessels permeability in real-time in dorsal-chamber-bearing mice exposed in a pilot study using wide-band signal applicators. Our pilot study conducted within the applicator and performed at the laboratory scale suggests that the exposure to wide-band signals with the amplitude of 47.5 kV/m does not result in increased vessel permeability. MDPI 2021-08-07 /pmc/articles/PMC8395230/ /pubmed/34445226 http://dx.doi.org/10.3390/ijms22168516 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kolosnjaj-Tabi, Jelena
Golzio, Muriel
Bellard, Elisabeth
Catrain, Alexandre
Chretiennot, Thomas
Saurin, Quentin
Tarayre, Jacques
Vezinet, René
Rols, Marie-Pierre
High Power Electromagnetic Waves Exposure of Healthy and Tumor Bearing Mice: Assessment of Effects on Mice Growth, Behavior, Tumor Growth, and Vessel Permeabilization
title High Power Electromagnetic Waves Exposure of Healthy and Tumor Bearing Mice: Assessment of Effects on Mice Growth, Behavior, Tumor Growth, and Vessel Permeabilization
title_full High Power Electromagnetic Waves Exposure of Healthy and Tumor Bearing Mice: Assessment of Effects on Mice Growth, Behavior, Tumor Growth, and Vessel Permeabilization
title_fullStr High Power Electromagnetic Waves Exposure of Healthy and Tumor Bearing Mice: Assessment of Effects on Mice Growth, Behavior, Tumor Growth, and Vessel Permeabilization
title_full_unstemmed High Power Electromagnetic Waves Exposure of Healthy and Tumor Bearing Mice: Assessment of Effects on Mice Growth, Behavior, Tumor Growth, and Vessel Permeabilization
title_short High Power Electromagnetic Waves Exposure of Healthy and Tumor Bearing Mice: Assessment of Effects on Mice Growth, Behavior, Tumor Growth, and Vessel Permeabilization
title_sort high power electromagnetic waves exposure of healthy and tumor bearing mice: assessment of effects on mice growth, behavior, tumor growth, and vessel permeabilization
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395230/
https://www.ncbi.nlm.nih.gov/pubmed/34445226
http://dx.doi.org/10.3390/ijms22168516
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