Cargando…
Single- and Two-Electron Reduction of Nitroaromatic Compounds by Flavoenzymes: Mechanisms and Implications for Cytotoxicity
Nitroaromatic compounds (ArNO(2)) maintain their importance in relation to industrial processes, environmental pollution, and pharmaceutical application. The manifestation of toxicity/therapeutic action of nitroaromatics may involve their single- or two-electron reduction performed by various flavoe...
Autores principales: | Čėnas, Narimantas, Nemeikaitė-Čėnienė, Aušra, Kosychova, Lidija |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395237/ https://www.ncbi.nlm.nih.gov/pubmed/34445240 http://dx.doi.org/10.3390/ijms22168534 |
Ejemplares similares
-
Kinetics of Flavoenzyme-Catalyzed Reduction of Tirapazamine Derivatives: Implications for Their Prooxidant Cytotoxicity
por: Nemeikaitė-Čėnienė, Aušra, et al.
Publicado: (2019) -
Enzymatic Redox Properties and Cytotoxicity of Irreversible Nitroaromatic Thioredoxin Reductase Inhibitors in Mammalian Cells
por: Nemeikaitė-Čėnienė, Aušra, et al.
Publicado: (2023) -
Aerobic Cytotoxicity of Aromatic N-Oxides: The Role of NAD(P)H:Quinone Oxidoreductase (NQO1)
por: Nemeikaitė-Čėnienė, Aušra, et al.
Publicado: (2020) -
Redox Proteomic Profile of Tirapazamine-Resistant Murine Hepatoma Cells
por: Nemeikaitė-Čėnienė, Aušra, et al.
Publicado: (2023) -
Mechanism of Two-/Four-Electron Reduction of Nitroaromatics by Oxygen-Insensitive Nitroreductases: The Role of a Non-Enzymatic Reduction Step
por: Valiauga, Benjaminas, et al.
Publicado: (2018)