Toward Understanding the Mechanisms of Malignant Peripheral Nerve Sheath Tumor Development

Malignant peripheral nerve sheath tumors (MPNSTs) originate from the neural crest lineage and are associated with the neurofibromatosis type I syndrome. MPNST is an unmet clinical need. In this review article, we summarize the knowledge and discuss research perspectives related to (1) the natural hi...

Descripción completa

Detalles Bibliográficos
Autores principales: Mohamad, Teddy, Plante, Camille, Brosseau, Jean-Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395254/
https://www.ncbi.nlm.nih.gov/pubmed/34445326
http://dx.doi.org/10.3390/ijms22168620
_version_ 1783744131765370880
author Mohamad, Teddy
Plante, Camille
Brosseau, Jean-Philippe
author_facet Mohamad, Teddy
Plante, Camille
Brosseau, Jean-Philippe
author_sort Mohamad, Teddy
collection PubMed
description Malignant peripheral nerve sheath tumors (MPNSTs) originate from the neural crest lineage and are associated with the neurofibromatosis type I syndrome. MPNST is an unmet clinical need. In this review article, we summarize the knowledge and discuss research perspectives related to (1) the natural history of MPNST development; (2) the mouse models recapitulating the progression from precursor lesions to MPNST; (3) the role of the tumor microenvironment in MPNST development, and (4) the signaling pathways linked to MPNST development.
format Online
Article
Text
id pubmed-8395254
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83952542021-08-28 Toward Understanding the Mechanisms of Malignant Peripheral Nerve Sheath Tumor Development Mohamad, Teddy Plante, Camille Brosseau, Jean-Philippe Int J Mol Sci Review Malignant peripheral nerve sheath tumors (MPNSTs) originate from the neural crest lineage and are associated with the neurofibromatosis type I syndrome. MPNST is an unmet clinical need. In this review article, we summarize the knowledge and discuss research perspectives related to (1) the natural history of MPNST development; (2) the mouse models recapitulating the progression from precursor lesions to MPNST; (3) the role of the tumor microenvironment in MPNST development, and (4) the signaling pathways linked to MPNST development. MDPI 2021-08-10 /pmc/articles/PMC8395254/ /pubmed/34445326 http://dx.doi.org/10.3390/ijms22168620 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mohamad, Teddy
Plante, Camille
Brosseau, Jean-Philippe
Toward Understanding the Mechanisms of Malignant Peripheral Nerve Sheath Tumor Development
title Toward Understanding the Mechanisms of Malignant Peripheral Nerve Sheath Tumor Development
title_full Toward Understanding the Mechanisms of Malignant Peripheral Nerve Sheath Tumor Development
title_fullStr Toward Understanding the Mechanisms of Malignant Peripheral Nerve Sheath Tumor Development
title_full_unstemmed Toward Understanding the Mechanisms of Malignant Peripheral Nerve Sheath Tumor Development
title_short Toward Understanding the Mechanisms of Malignant Peripheral Nerve Sheath Tumor Development
title_sort toward understanding the mechanisms of malignant peripheral nerve sheath tumor development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395254/
https://www.ncbi.nlm.nih.gov/pubmed/34445326
http://dx.doi.org/10.3390/ijms22168620
work_keys_str_mv AT mohamadteddy towardunderstandingthemechanismsofmalignantperipheralnervesheathtumordevelopment
AT plantecamille towardunderstandingthemechanismsofmalignantperipheralnervesheathtumordevelopment
AT brosseaujeanphilippe towardunderstandingthemechanismsofmalignantperipheralnervesheathtumordevelopment

Ejemplares similares