Cargando…
Platelet-Derived Extracellular Vesicles for Regenerative Medicine
Extracellular vesicles (EVs) present a great potential for the development of new treatments in the biomedical field. To be used as therapeutics, many different sources have been used for EVs obtention, while only a few studies have addressed the use of platelet-derived EVs (pEVs). In fact, pEVs hav...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395287/ https://www.ncbi.nlm.nih.gov/pubmed/34445286 http://dx.doi.org/10.3390/ijms22168580 |
_version_ | 1783744138339942400 |
---|---|
author | Antich-Rosselló, Miquel Forteza-Genestra, Maria Antònia Monjo, Marta Ramis, Joana M. |
author_facet | Antich-Rosselló, Miquel Forteza-Genestra, Maria Antònia Monjo, Marta Ramis, Joana M. |
author_sort | Antich-Rosselló, Miquel |
collection | PubMed |
description | Extracellular vesicles (EVs) present a great potential for the development of new treatments in the biomedical field. To be used as therapeutics, many different sources have been used for EVs obtention, while only a few studies have addressed the use of platelet-derived EVs (pEVs). In fact, pEVs have been shown to intervene in different healing responses, thus some studies have evaluated their regenerative capability in wound healing or hemorrhagic shock. Even more, pEVs have proven to induce cellular differentiation, enhancing musculoskeletal or neural regeneration. However, the obtention and characterization of pEVs is widely heterogeneous and differs from the recommendations of the International Society for Extracellular Vesicles. Therefore, in this review, we aim to present the main advances in the therapeutical use of pEVs in the regenerative medicine field while highlighting the isolation and characterization steps followed. The main goal of this review is to portray the studies performed in order to enhance the translation of the pEVs research into feasible therapeutical applications. |
format | Online Article Text |
id | pubmed-8395287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83952872021-08-28 Platelet-Derived Extracellular Vesicles for Regenerative Medicine Antich-Rosselló, Miquel Forteza-Genestra, Maria Antònia Monjo, Marta Ramis, Joana M. Int J Mol Sci Review Extracellular vesicles (EVs) present a great potential for the development of new treatments in the biomedical field. To be used as therapeutics, many different sources have been used for EVs obtention, while only a few studies have addressed the use of platelet-derived EVs (pEVs). In fact, pEVs have been shown to intervene in different healing responses, thus some studies have evaluated their regenerative capability in wound healing or hemorrhagic shock. Even more, pEVs have proven to induce cellular differentiation, enhancing musculoskeletal or neural regeneration. However, the obtention and characterization of pEVs is widely heterogeneous and differs from the recommendations of the International Society for Extracellular Vesicles. Therefore, in this review, we aim to present the main advances in the therapeutical use of pEVs in the regenerative medicine field while highlighting the isolation and characterization steps followed. The main goal of this review is to portray the studies performed in order to enhance the translation of the pEVs research into feasible therapeutical applications. MDPI 2021-08-10 /pmc/articles/PMC8395287/ /pubmed/34445286 http://dx.doi.org/10.3390/ijms22168580 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Antich-Rosselló, Miquel Forteza-Genestra, Maria Antònia Monjo, Marta Ramis, Joana M. Platelet-Derived Extracellular Vesicles for Regenerative Medicine |
title | Platelet-Derived Extracellular Vesicles for Regenerative Medicine |
title_full | Platelet-Derived Extracellular Vesicles for Regenerative Medicine |
title_fullStr | Platelet-Derived Extracellular Vesicles for Regenerative Medicine |
title_full_unstemmed | Platelet-Derived Extracellular Vesicles for Regenerative Medicine |
title_short | Platelet-Derived Extracellular Vesicles for Regenerative Medicine |
title_sort | platelet-derived extracellular vesicles for regenerative medicine |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395287/ https://www.ncbi.nlm.nih.gov/pubmed/34445286 http://dx.doi.org/10.3390/ijms22168580 |
work_keys_str_mv | AT antichrossellomiquel plateletderivedextracellularvesiclesforregenerativemedicine AT fortezagenestramariaantonia plateletderivedextracellularvesiclesforregenerativemedicine AT monjomarta plateletderivedextracellularvesiclesforregenerativemedicine AT ramisjoanam plateletderivedextracellularvesiclesforregenerativemedicine |